358 research outputs found
Knowledge Transfer Preferences of Expert Employees Nearing Retirement
Managers of organizations face increasing rates of retiring Baby Boomers as that generation begins to leave the workforce. Some managers of organizations have no formalized knowledge transfer strategies in place to reduce the lost productivity and negative financial effects of these retiring employees. The purpose of this single-site case study was to explore the knowledge transfer preferences of expert scientific support employees nearing retirement at a United States national laboratory in northern California. Understanding the preferences of employees nearing retirement may allow managers to affect the business practice of promoting organizational learning by implementing strategies that catalyze knowledge transfer from expert employees. Systems theory, expectancy theory, knowledge management theory, and organizational learning theory concepts provided the framework. Semistructured interviews with 24 expert scientific support employees provided data, which were subsequently coded and analyzed using the pawing technique. The analysis of themes revealed mentoring to be the preferred method of knowledge transfer, the barriers to knowledge transfer and multiple types of knowledge transfer, and the impact of lack of knowledge transfer on productivity. Public research organization managers implementing effective knowledge transfer programs may increase the potential for scientific discoveries affecting social change through increased prosperity of citizens who could benefit from the derivative advances in energy research
The Role of the President, the Senate and Congress with Respect to Arms Control Treaties Concluded by the United States - United States
Comparing Hitler and Stalin: Certain Cultural Considerations
There is a great temptation to compare the Adolf Hitler and Joseph Stalin. This is true for two reasons: first, the careers of both men converged at the same point in history, thus doubling the impact both made and second, because the names Adolf Hitler and Joseph Stalin have become metaphors for ideologies and crimes that today are reviled. The question then arises: who was worse, Hitler or Stalin? This project shows that there is no viable, credible, definitive, or final answer to this question, and that prevailing attitudes about Hitler and Stalin have become so ingrained in contemporary society as to render any meaningful or useful comparison virtually impossible. Tragically, it might even be impossible to render a final totally objective judgment of their actions. This is the most disturbing element of this work
PIWI Homologs Mediate Histone H4 mRNA Localization to Planarian Chromatoid Bodies
The well-known regenerative abilities of planarian flatworms are attributed to a population of adult stem cells called neoblasts that proliferate and differentiate to produce all cell types. A characteristic feature of neoblasts is the presence of large cytoplasmic ribonucleoprotein granules named chromatoid bodies, the function of which has remained largely elusive. This study shows that histone mRNAs are a common component of chromatoid bodies. Our experiments also demonstrate that accumulation of histone mRNAs, which is typically restricted to the S phase of eukaryotic cells, is extended during the cell cycle of neoblasts. The planarian PIWI homologs SMEDWI-1 and SMEDWI-3 are required for proper localization of germinal histone H4 (gH4) mRNA to chromatoid bodies. The association between histone mRNA and chromatoid body components extends beyond gH4 mRNA, since transcripts of other core histone genes were also found in these structures. Additionally, piRNAs corresponding to loci of every core histone type have been identified. Altogether, this work provides evidence that links PIWI proteins and chromatoid bodies to histone mRNA regulation in planarian stem cells. The molecular similarities between neoblasts and undifferentiated cells of other organisms raise the possibility that PIWI proteins might also regulate histone mRNAs in stem cells and germ cells of other metazoans
The California-Kepler Survey. III. A Gap in the Radius Distribution of Small Planets
The size of a planet is an observable property directly connected to the
physics of its formation and evolution. We used precise radius measurements
from the California-Kepler Survey (CKS) to study the size distribution of 2025
planets in fine detail. We detect a factor of 2 deficit
in the occurrence rate distribution at 1.5-2.0 R. This gap splits
the population of close-in ( < 100 d) small planets into two size regimes:
R < 1.5 R and R = 2.0-3.0 R, with few planets in
between. Planets in these two regimes have nearly the same intrinsic frequency
based on occurrence measurements that account for planet detection
efficiencies. The paucity of planets between 1.5 and 2.0 R supports
the emerging picture that close-in planets smaller than Neptune are composed of
rocky cores measuring 1.5 R or smaller with varying amounts of
low-density gas that determine their total sizes.Comment: Paper III in the California-Kepler Survey series, accepted to the
Astronomical Journa
The California-Kepler Survey V. Peas in a Pod: Planets in a Kepler Multi-planet System are Similar in Size and Regularly Spaced
We have established precise planet radii, semimajor axes, incident stellar
fluxes, and stellar masses for 909 planets in 355 multi-planet systems
discovered by Kepler. In this sample, we find that planets within a single
multi-planet system have correlated sizes: each planet is more likely to be the
size of its neighbor than a size drawn at random from the distribution of
observed planet sizes. In systems with three or more planets, the planets tend
to have a regular spacing: the orbital period ratios of adjacent pairs of
planets are correlated. Furthermore, the orbital period ratios are smaller in
systems with smaller planets, suggesting that the patterns in planet sizes and
spacing are linked through formation and/or subsequent orbital dynamics. Yet,
we find that essentially no planets have orbital period ratios smaller than
, regardless of planet size. Using empirical mass-radius relationships, we
estimate the mutual Hill separations of planet pairs. We find that of
the planet pairs are at least 10 mutual Hill radii apart, and that a spacing of
mutual Hill radii is most common. We also find that when comparing
planet sizes, the outer planet is larger in of cases, and the
typical ratio of the outer to inner planet size is positively correlated with
the temperature difference between the planets. This could be the result of
photo-evaporation.Comment: Published in The Astronomical Journal. 15 pages, 17 figure
The California-Kepler Survey. II. Precise Physical Properties of 2025 Kepler Planets and Their Host Stars
We present stellar and planetary properties for 1305 Kepler Objects of
Interest (KOIs) hosting 2025 planet candidates observed as part of the
California-Kepler Survey. We combine spectroscopic constraints, presented in
Paper I, with stellar interior modeling to estimate stellar masses, radii, and
ages. Stellar radii are typically constrained to 11%, compared to 40% when only
photometric constraints are used. Stellar masses are constrained to 4%, and
ages are constrained to 30%. We verify the integrity of the stellar parameters
through comparisons with asteroseismic studies and Gaia parallaxes. We also
recompute planetary radii for 2025 planet candidates. Because knowledge of
planetary radii is often limited by uncertainties in stellar size, we improve
the uncertainties in planet radii from typically 42% to 12%. We also leverage
improved knowledge of stellar effective temperature to recompute incident
stellar fluxes for the planets, now precise to 21%, compared to a factor of two
when derived from photometry.Comment: 13 pages, 4 figures, 4 tables, accepted for publication in AJ; full
versions of tables 3 and 4 are include
The California-Kepler Survey. I. High Resolution Spectroscopy of 1305 Stars Hosting Kepler Transiting Planets
The California-Kepler Survey (CKS) is an observational program to improve our
knowledge of the properties of stars found to host transiting planets by NASA's
Kepler Mission. The improvement stems from new high-resolution optical spectra
obtained using HIRES at the W. M. Keck Observatory. The CKS stellar sample
comprises 1305 stars classified as Kepler Objects of Interest, hosting a total
of 2075 transiting planets. The primary sample is magnitude-limited (Kp < 14.2)
and contains 960 stars with 1385 planets. The sample was extended to include
some fainter stars that host multiple planets, ultra short period planets, or
habitable zone planets. The spectroscopic parameters were determined with two
different codes, one based on template matching and the other on direct
spectral synthesis using radiative transfer. We demonstrate a precision of 60 K
in effective temperature, 0.10 dex in surface gravity, 0.04 dex in [Fe/H], and
1.0 km/s in projected rotational velocity. In this paper we describe the CKS
project and present a uniform catalog of spectroscopic parameters. Subsequent
papers in this series present catalogs of derived stellar properties such as
mass, radius and age; revised planet properties; and statistical explorations
of the ensemble. CKS is the largest survey to determine the properties of
Kepler stars using a uniform set of high-resolution, high signal-to-noise ratio
spectra. The HIRES spectra are available to the community for independent
analyses.Comment: 20 pages, 19 figures, accepted for publication in AJ; a full version
of Table 5 is included as tab_cks.csv and tab_cks.te
Interaction of CarD with RNA polymerase mediates Mycobacterium tuberculosis viability, rifampin resistance, and pathogenesis
Mycobacterium tuberculosis infection continues to cause substantial human suffering. New chemotherapeutic strategies, which require insight into the pathways essential for M. tuberculosis pathogenesis, are imperative. We previously reported that depletion of the CarD protein in mycobacteria compromises viability, resistance to oxidative stress and fluoroquinolones, and pathogenesis. CarD associates with the RNA polymerase (RNAP), but it has been unknown which of the diverse functions of CarD are mediated through the RNAP; this question must be answered to understand the CarD mechanism of action. Herein, we describe the interaction between the M. tuberculosis CarD and the RNAP β subunit and identify point mutations that weaken this interaction. The characterization of mycobacterial strains with attenuated CarD/RNAP β interactions demonstrates that the CarD/RNAP β association is required for viability and resistance to oxidative stress but not for fluoroquinolone resistance. Weakening the CarD/RNAP β interaction also increases the sensitivity of mycobacteria to rifampin and streptomycin. Surprisingly, depletion of the CarD protein did not affect sensitivity to rifampin. These findings define the CarD/RNAP interaction as a new target for chemotherapeutic intervention that could also improve the efficacy of rifampin treatment of tuberculosis. In addition, our data demonstrate that weakening the CarD/RNAP β interaction does not completely phenocopy the depletion of CarD and support the existence of functions for CarD independent of direct RNAP binding
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