Magnetic Doppler imaging of the roAp star HD 24712

We present the first magnetic Doppler images of a rapidly oscillating Ap (roAp) star. We deduce information about magnetic field geometry and abundance distributions of a number of chemical elements on the surface of the hitherto best studied roAp star, HD 24712, using the magnetic Doppler imaging (MDI) code, INVERS10, which allows us to reconstruct simultaneously and consistently the magnetic field geometry and elemental abundance distributions on a stellar surface. For this purpose we analyse time series spectra obtained in Stokes I and V parameters with the SOFIN polarimeter at the Nordic Optical Telescope and recover surface abundance structures of sixteen different chemical elements, respectively ions, including Mg, Ca, Sc, Ti, Cr, Fe, Co, Ni, Y, La, Ce, Pr, Nd, Gd, Tb, and Dy. For the rare earth elements (REE) Pr and Nd separate maps were obtained using lines of the first and the second ionization stage. We find and confirm a clear dipolar structure of the surface magnetic field and an unexpected correlation of elemental abundances with respect to this field: one group of elements accumulates solely where the positive magnetic pole is visible, whereas the other group avoids this region and is enhanced where the magnetic equatorial region dominates the visible stellar surface. We also observe relative shifts of abundance enhancement- or depletion regions between the various elements exhibiting otherwise similar behaviour.Comment: 13 pages, 9 figures, to be published in Astronomy and Astrophysic

Ground-state energy and depletions for a dilute binary Bose gas

When calculating the ground-state energy of a weakly interacting Bose gas with the help of the customary contact pseudopotential, one meets an artifical ultraviolet divergence which is caused by the incorrect treatment of the true interparticle interactions at small distances. We argue that this problem can be avoided by retaining the actual, momentum-dependent interaction matrix elements, and use this insight for computing both the ground-state energy and the depletions of a binary Bose gas mixture. Even when considering the experimentally relevant case of equal masses of both species, the resulting expressions are quite involved, and no straightforward generalizations of the known single-species formulas. On the other hand, we demonstrate in detail how these latter formulas are recovered from our two-species results in the limit of vanishing interspecies interaction.Comment: 11 pages, Phys. Rev. A in pres

Lattice Black Holes

We study the Hawking process on lattices falling into static black holes. The motivation is to understand how the outgoing modes and Hawking radiation can arise in a setting with a strict short distance cutoff in the free-fall frame. We employ two-dimensional free scalar field theory. For a falling lattice with a discrete time-translation symmetry we use analytical methods to establish that, for Killing frequency $\omega$ and surface gravity $\kappa$ satisfying $\kappa\ll\omega^{1/3}\ll 1$ in lattice units, the continuum Hawking spectrum is recovered. The low frequency outgoing modes arise from exotic ingoing modes with large proper wavevectors that "refract" off the horizon. In this model with time translation symmetry the proper lattice spacing goes to zero at spatial infinity. We also consider instead falling lattices whose proper lattice spacing is constant at infinity and therefore grows with time at any finite radius. This violation of time translation symmetry is visible only at wavelengths comparable to the lattice spacing, and it is responsible for transmuting ingoing high Killing frequency modes into low frequency outgoing modes.Comment: 26 pages, LaTeX, 2 figures included with psfig. Several improvements in the presentation. One figure added. Final version to appear in Phys.Rev.

p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels.

BackgroundAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disease with few treatment options other than renal replacement therapy. p21, a cyclin kinase inhibitor which has pleiotropic effects on the cell cycle, in many cases acts to suppress cell cycle progression and to prevent apoptosis. Because defects in cell cycle arrest and apoptosis of renal tubular epithelial cells occur in PKD, and in light of earlier reports that polycystin-1 upregulates p21 and that the cyclin-dependent kinase inhibitor roscovitine arrests progression in a mouse model, we asked whether (1) p21 deficiency might underlie ADPKD and (2) the mechanism of the salutary roscovitine effect on PKD involves p21.Methodsp21 levels in human and animal tissue samples as well as cell lines were examined by immunoblotting and/or immunohistochemisty. Apoptosis was assessed by PARP cleavage. p21 expression was attenuated in a renal tubular epithelial cell line by antisense methods, and proliferation in response to p21 attenuation and to roscovitine was assessed by the MTT assay.ResultsWe show that p21 is decreased in human as well as a non-transgenic rat model of ADPKD. In addition, hepatocyte growth factor, which induces transition from a cystic to a tubular phenotype, increases p21 levels. Furthermore, attenuation of p21 results in augmentation of cell cycle transit in vitro. Thus, levels of p21 are inversely correlated with renal tubular epithelial cell proliferation. Roscovitine, which has been shown to arrest progression in a murine model of PKD, increases p21 levels and decreases renal tubular epithelial cell proliferation, with no affect on apoptosis.ConclusionThe novelty of our study is the demonstration in vivo in humans and rat models of a decrement of p21 in cystic kidneys as compared to non-cystic kidneys. Validation of a potential pathogenetic model of increased cyst formation due to enhanced epithelial proliferation and apoptosis mediated by p21 suggests a mechanism for the salutary effect of roscovitine in ADPKD and supports further investigation of p21 as a target for future therapy

Dynamics of Interacting Scalar Fields in Expanding Space-Time

The effective equation of motion is derived for a scalar field interacting with other fields in a Friedman-Robertson-Walker background space-time. The dissipative behavior reflected in this effective evolution equation is studied both in simplified approximations as well as numerically. The relevance of our results to inflation are considered both in terms of the evolution of the inflaton field as well as its fluctuation spectrum. A brief examination also is made of supersymmetric models that yield dissipative effects during inflation.Comment: 36 pages, 12 figures. Version published in the Physical Review

A nanomechanical resonator shuttling single electrons at radio frequencies

We observe transport of electrons through a metallic island on the tip of a nanomechanical pendulum. The resulting tunneling current shows distinct features corresponding to the discrete mechanical eigenfrequencies of the pendulum. We report on measurements covering the temperature range from 300 K down to 4.2 K. We explain the I-V curve, which differs from previous theoretical predictions, with model calculations based on a Master equation approach.Comment: 5 pages, 4 jpeg-figure

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.

A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of the ZAP-70 protein tyrosine kinase with the TCR complex. Human T cell leukemia virus type I-transformed CD4+ T cell lines were established from ZAP-70-deficient patients and normal controls. ZAP-70 was expressed and appropriately phosphorylated in normal T cell lines after TCR engagement, but was not detected in T cell lines from ZAP-70-deficient patients. To determine whether signaling could be reconstituted, wild-type ZAP-70 was introduced into deficient cells with a ZAP-70 retroviral vector. High titer producer clones expressing ZAP-70 were generated in the Gibbon ape leukemia virus packaging line PG13. After transduction, ZAP-70 was detected at levels equivalent to those observed in normal cells, and was appropriately phosphorylated on tyrosine after receptor engagement. The kinase activity of ZAP-70 in the reconstituted cells was also appropriately upregulated by receptor aggregation. Moreover, normal and transduced cells, but not ZAP-70-deficient cells, were able to mobilize calcium after receptor ligation, indicating that proximal TCR signaling was reconstituted. These results indicate that this form of SCID may be corrected by gene therapy

Z_N Phases in Hot Gauge Theories

We argue that the \zn phases of hot gauge theories cannot be realized as a real system with an Hermitean density matrix.Comment: 7 page

Damage-free single-mode transmission of deep-UV light in hollow-core PCF

Transmission of UV light with high beam quality and pointing stability is desirable for many experiments in atomic, molecular and optical physics. In particular, laser cooling and coherent manipulation of trapped ions with transitions in the UV require stable, single-mode light delivery. Transmitting even ~2 mW CW light at 280 nm through silica solid-core fibers has previously been found to cause transmission degradation after just a few hours due to optical damage. We show that photonic crystal fiber of the kagom\'e type can be used for effectively single-mode transmission with acceptable loss and bending sensitivity. No transmission degradation was observed even after >100 hours of operation with 15 mW CW input power. In addition it is shown that implementation of the fiber in a trapped ion experiment significantly increases the coherence times of the internal state transfer due to an increase in beam pointing stability

The MHD Kelvin-Helmholtz Instability II: The Roles of Weak and Oblique Fields in Planar Flows

We have carried out high resolution MHD simulations of the nonlinear evolution of Kelvin-Helmholtz unstable flows in 2 1/2 dimensions. The modeled flows and fields were initially uniform except for a thin shear layer with a hyperbolic tangent velocity profile and a small, normal mode perturbation. The calculations consider periodic sections of flows containing magnetic fields parallel to the shear layer, but projecting over a full range of angles with respect to the flow vectors. They are intended as preparation for fully 3D calculations and to address two specific questions raised in earlier work: 1) What role, if any, does the orientation of the field play in nonlinear evolution of the MHD Kelvin-Helmholtz instability in 2 1/2 D. 2) Given that the field is too weak to stabilize against a linear perturbation of the flow, how does the nonlinear evolution of the instability depend on strength of the field. The magnetic field component in the third direction contributes only through minor pressure contributions, so the flows are essentially 2D. Even a very weak field can significantly enhance the rate of energy dissipation. In all of the cases we studied magnetic field amplification by stretching in the vortex is limited by tearing mode, ``fast'' reconnection events that isolate and then destroy magnetic flux islands within the vortex and relax the fields outside the vortex. If the magnetic tension developed prior to reconnection is comparable to Reynolds stresses in the flow, that flow is reorganized during reconnection. Otherwise, the primary influence on the plasma is generation of entropy. The effective expulsion of flux from the vortex is very similar to that shown by Weiss for passive fields in idealized vortices with large magnetic Reynolds numbers. We demonstrated that thisComment: 23 pages of ApJ Latex (aaspp4.sty) with 10 figures, high resolution postscript images for figs 4-9 available through anonymous at ftp://ftp.msi.umn.edu/pub/twj To appear in the June 10, 1997 Ap