Creating Beauty Out of Darkness: An Exploration into the Artistic Resistance of Jewish Music of the Holocaust

When we think of the the Holocaust, we rightfully remember the atrocities committed by Hitler and his Nazi regime. However, we often fail to recognize the beautiful, albeit tragic, music that was composed in the concentration camps, specifically in Terezín. In this project, I study the Jewish composers and lyricists who contributed to this musical output, specifically Viktor Ullmann, Hans Krása, Pavel Haas, and Schmerke Kaczerginski. The goal of this study is to identify and examine specific components of resistance within these composers’ works and show how they come together to create a larger opposition to Hitler’s regime despite oppressive and exploitative conditions. In going about my research, I studied numerous musical scores written during the Holocaust. I then chose those that best represented this artistic resistance and elaborated on them. I also read articles, books, and documents that gave me a further insight into the art and life of this tragic period. Additionally, I was able to obtain an interview with Terezín survivor Inge Auerbacher, who spoke about her experiences. I found that these composers and lyricists integrated resilience into their work through themes, lyrics, Jewish and cultural folk elements, and the very act of making art itself. I was astonished by the strength and ability of these men to create art and express themselves under these conditions. They left a Jewish legacy to be passed down to posterity despite their own eventual deaths, and in doing so ensured that the Jewish people, and art itself, would live on

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Longitudinal multi-omics of host-microbe dynamics in prediabetes.

Type 2 diabetes mellitus (T2D) is a growing health problem, but little is known about its early disease stages, its effects on biological processes or the transition to clinical T2D. To understand the earliest stages of T2D better, we obtained samples from 106 healthy individuals and individuals with prediabetes over approximately four years and performed deep profiling of transcriptomes, metabolomes, cytokines, and proteomes, as well as changes in the microbiome. This rich longitudinal data set revealed many insights: first, healthy profiles are distinct among individuals while displaying diverse patterns of intra- and/or inter-personal variability. Second, extensive host and microbial changes occur during respiratory viral infections and immunization, and immunization triggers potentially protective responses that are distinct from responses to respiratory viral infections. Moreover, during respiratory viral infections, insulin-resistant participants respond differently than insulin-sensitive participants. Third, global co-association analyses among the thousands of profiled molecules reveal specific host-microbe interactions that differ between insulin-resistant and insulin-sensitive individuals. Last, we identified early personal molecular signatures in one individual that preceded the onset of T2D, including the inflammation markers interleukin-1 receptor agonist (IL-1RA) and high-sensitivity C-reactive protein (CRP) paired with xenobiotic-induced immune signalling. Our study reveals insights into pathways and responses that differ between glucose-dysregulated and healthy individuals during health and disease and provides an open-access data resource to enable further research into healthy, prediabetic and T2D states