510 research outputs found
Realtime calibration of the A4 electromagnetic lead fluoride calorimeter
Sufficient energy resolution is the key issue for the calorimetry in particle
and nuclear physics. The calorimeter of the A4 parity violation experiment at
MAMI is a segmented calorimeter where the energy of an event is determined by
summing the signals of neighbouring channels. In this case the precise matching
of the individual modules is crucial to obtain a good energy resolution. We
have developped a calibration procedure for our total absorbing electromagnetic
calorimeter which consists of 1022 lead fluoride (PbF_2) crystals. This
procedure reconstructs the the single-module contributions to the events by
solving a linear system of equations, involving the inversion of a 1022 x
1022-matrix. The system has shown its functionality at beam energies between
300 and 1500 MeV and represents a new and fast method to keep the calorimeter
permanently in a well-calibrated state
A luminosity monitor for the A4 parity violation experiment at MAMI
A water Cherenkov luminosity monitor system with associated electronics has
been developed for the A4 parity violation experiment at MAMI. The detector
system measures the luminosity of the hydrogen target hit by the MAMI electron
beam and monitors the stability of the liquid hydrogen target. Both is required
for the precise study of the count rate asymmetries in the scattering of
longitudinally polarized electrons on unpolarized protons. Any helicity
correlated fluctuation of the target density leads to false asymmetries. The
performance of the luminosity monitor, investigated in about 2000 hours with
electron beam, and the results of its application in the A4 experiment are
presented.Comment: 22 pages, 12 figures, submitted to NIM
Measurement of the Transverse Beam Spin Asymmetry in Elastic Electron Proton Scattering and the Inelastic Contribution to the Imaginary Part of the Two-Photon Exchange Amplitude
We report on a measurement of the asymmetry in the scattering of transversely
polarized electrons off unpolarized protons, A, at two Q values of
\qsquaredaveragedlow (GeV/c) and \qsquaredaveragedhighII (GeV/c) and a
scattering angle of . The measured transverse
asymmetries are A(Q = \qsquaredaveragedlow (GeV/c)) =
(\experimentalasymmetry alulowcorr \statisticalerrorlow
\combinedsyspolerrorlowalucor) 10 and
A(Q = \qsquaredaveragedhighII (GeV/c)) = (\experimentalasymme
tryaluhighcorr \statisticalerrorhigh
\combinedsyspolerrorhighalucor) 10. The first
errors denotes the statistical error and the second the systematic
uncertainties. A arises from the imaginary part of the two-photon
exchange amplitude and is zero in the one-photon exchange approximation. From
comparison with theoretical estimates of A we conclude that
N-intermediate states give a substantial contribution to the imaginary
part of the two-photon amplitude. The contribution from the ground state proton
to the imaginary part of the two-photon exchange can be neglected. There is no
obvious reason why this should be different for the real part of the two-photon
amplitude, which enters into the radiative corrections for the Rosenbluth
separation measurements of the electric form factor of the proton.Comment: 4 figures, submitted to PRL on Oct.
Evidence for Strange Quark Contributions to the Nucleon's Form Factors at = 0.108 (GeV/c)
We report on a measurement of the parity violating asymmetry in the elastic
scattering of polarized electrons off unpolarized protons with the A4 apparatus
at MAMI in Mainz at a four momentum transfer value of = \Qsquare
(GeV/c) and at a forward electron scattering angle of 30. The measured asymmetry is = (\Aphys
\Deltastat \Deltasyst) 10. The
expectation from the Standard Model assuming no strangeness contribution to the
vector current is A = (\Azero \DeltaAzero) 10. We
have improved the statistical accuracy by a factor of 3 as compared to our
previous measurements at a higher . We have extracted the strangeness
contribution to the electromagnetic form factors from our data to be +
\FakGMs = \GEsGMs \DeltaGEsGMs at = \Qsquare (GeV/c).
As in our previous measurement at higher momentum transfer for + 0.230
, we again find the value for + \FakGMs to be positive,
this time at an improved significance level of 2 .Comment: 4 pages, 3 figure
Measurement of Strange Quark Contributions to the Nucleon's Form Factors at Q^2=0.230 (GeV/c)^2
We report on a measurement of the parity-violating asymmetry in the
scattering of longitudinally polarized electrons on unpolarized protons at a
of 0.230 (GeV/c)^2 and a scattering angle of \theta_e = 30^o - 40^o.
Using a large acceptance fast PbF_2 calorimeter with a solid angle of
\Delta\Omega = 0.62 sr the A4 experiment is the first parity violation
experiment to count individual scattering events. The measured asymmetry is
A_{phys} =(-5.44 +- 0.54_{stat} +- 0.27_{\rm sys}) 10^{-6}. The Standard Model
expectation assuming no strangeness contributions to the vector form factors is
. The difference is a direct measurement of the
strangeness contribution to the vector form factors of the proton. The
extracted value is G^s_E + 0.225 G^s_M = 0.039 +- 0.034 or F^s_1 + 0.130 F^s_2
= 0.032 +- 0.028.Comment: 5 pages, 3 figures, submitted to Phys. Rev. Letters on Dec 11, 200
Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer.
The recognition that colorectal cancer (CRC) is a heterogeneous disease in terms of clinical behaviour and response to therapy translates into an urgent need for robust molecular disease subclassifiers that can explain this heterogeneity beyond current parameters (MSI, KRAS, BRAF). Attempts to fill this gap are emerging. The Cancer Genome Atlas (TGCA) reported two main CRC groups, based on the incidence and spectrum of mutated genes, and another paper reported an EMT expression signature defined subgroup. We performed a prior free analysis of CRC heterogeneity on 1113 CRC gene expression profiles and confronted our findings to established molecular determinants and clinical, histopathological and survival data. Unsupervised clustering based on gene modules allowed us to distinguish at least five different gene expression CRC subtypes, which we call surface crypt-like, lower crypt-like, CIMP-H-like, mesenchymal and mixed. A gene set enrichment analysis combined with literature search of gene module members identified distinct biological motifs in different subtypes. The subtypes, which were not derived based on outcome, nonetheless showed differences in prognosis. Known gene copy number variations and mutations in key cancer-associated genes differed between subtypes, but the subtypes provided molecular information beyond that contained in these variables. Morphological features significantly differed between subtypes. The objective existence of the subtypes and their clinical and molecular characteristics were validated in an independent set of 720 CRC expression profiles. Our subtypes provide a novel perspective on the heterogeneity of CRC. The proposed subtypes should be further explored retrospectively on existing clinical trial datasets and, when sufficiently robust, be prospectively assessed for clinical relevance in terms of prognosis and treatment response predictive capacity. Original microarray data were uploaded to the ArrayExpress database (http://www.ebi.ac.uk/arrayexpress/) under Accession Nos E-MTAB-990 and E-MTAB-1026. © 2013 Swiss Institute of Bioinformatics. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland
Asexuality: Classification and characterization
This is a post-print version of the article. The official published version can be obtaineed at the link below.The term “asexual” has been defined in many different ways and asexuality has received very little research attention. In a small qualitative study (N = 4), individuals who self-identified as asexual were interviewed to help formulate hypotheses for a larger study. The second larger study was an online survey drawn from a convenience sample designed to better characterize asexuality and to test predictors of asexual identity. A convenience sample of 1,146 individuals (N = 41 self-identified asexual) completed online questionnaires assessing sexual history, sexual inhibition and excitation, sexual desire, and an open-response questionnaire concerning asexual identity. Asexuals reported significantly less desire for sex with a partner, lower sexual arousability, and lower sexual excitation but did not differ consistently from non-asexuals in their sexual inhibition scores or their desire to masturbate. Content analyses supported the idea that low sexual desire is the primary feature predicting asexual identity
Моделі процесів захисту цілісності інформаційних об’єктів з використанням коду умовних лишків. Алгоритм нулізації
The models of processes of defense of integrity of information’s holding object with application of code of conditional tailings which provide high probabilities of exposure of violations of integrity and correction of the exposed curvatures are examined
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