Acute Outcomes for the Full US Cohort of the FLASH Mechanical Thrombectomy Registry in Pulmonary Embolism

Background Evidence supporting interventional pulmonary embolism (PE) treatment is needed. Aims We aimed to evaluate the acute safety and effectiveness of mechanical thrombectomy for intermediate- and high-risk PE in a large real-world population. Methods FLASH is a multicentre, prospective registry enrolling up to 1,000 US and European PE patients treated with mechanical thrombectomy using the FlowTriever System. The primary safety endpoint is a major adverse event composite including device-related death and major bleeding at 48 hours, and intraprocedural adverse events. Acute mortality and 48-hour outcomes are reported. Multivariate regression analysed characteristics associated with pulmonary artery pressure and dyspnoea improvement. Results Among 800 patients in the full US cohort, 76.7% had intermediate-high risk PE, 7.9% had high-risk PE, and 32.1% had thrombolytic contraindications. Major adverse events occurred in 1.8% of patients. All-cause mortality was 0.3% at 48-hour follow-up and 0.8% at 30-day follow-up, with no device-related deaths. Immediate haemodynamic improvements included a 7.6 mmHg mean drop in mean pulmonary artery pressure (-23.0%; p Conclusions Mechanical thrombectomy with the FlowTriever System demonstrates a favourable safety profile, improvements in haemodynamics and functional outcomes, and low 30-day mortality for intermediate- and high-risk PE

Shape and Compliance of Endothelial Cells after Shear Stress In Vitro or from Different Aortic Regions: Scanning Ion Conductance Microscopy Study

Objective: To measure the elongation and compliance of endothelial cells subjected to different patterns of shear stress in vitro, and to compare these parameters with the elongation and compliance of endothelial cells from different regions of the intact aorta. Materials and Methods: Porcine aortic endothelial cells were cultured for 6 days under static conditions or on an orbital shaker. The shaker generated a wave of medium, inducing pulsatile shear stress with a preferred orientation at the edge of the well or steadier shear stress with changing orientation at its centre. The topography and compliance of these cells and cells from the inner and outer curvature of ex vivo porcine aortic arches were measured by scanning ion conductance microscopy (SICM). Results: Cells cultured under oriented shear stress were more elongated and less compliant than cells grown under static conditions or under shear stress with no preferred orientation. Cells from the outer curvature of the aorta were more elongated and less compliant than cells from the inner curvature. Conclusion: The elongation and compliance of cultured endothelial cells vary according to the pattern of applied shear stress, and are inversely correlated. A similar inverse correlation occurs in the aortic arch, with variation between region

Off Mass Shell Effects in Hadron Electric Dipole Moments

We note that off the quark mass shell the operators $(p_i+p_f)_\mu\gamma_5$ and $i\sigma_{\mu\nu}(p_i -p_f)^\nu\gamma_5$, both of which reduce to $-\vec{\sigma}\cdot\vec{E}$ in the non-relativistic limit, are no longer identical. In this paper we explore the effects of this difference in the contribution of these quark electric moments to hadronic electric moments.Comment: 21 pages, 1 figure, Revtex, uses psfi

Electromagnetic Pion Form Factor and Neutral Pion Decay Width

The electromagnetic pion form factor, $F_\pi(q^2)$, is calculated for spacelike-$q^2$ in impulse approximation using a confining quark propagator, $S$, and a dressed quark-photon vertex, $\Gamma_\mu$, obtained from realistic, nonperturbative Dyson-Schwinger equation studies. Good agreement with the available data is obtained for $F_\pi(q^2)$ and other pion observables, including the decay $\pi^0 \rightarrow \gamma\,\gamma$. This calculation suggests that soft, nonperturbative contributions dominate $F_\pi(q^2)$ at presently accessible~$q^2$.Comment: 25 pages, LaTeX, elsart.sty, 5 figures, To appear in Nucl. Phys.

Isospin Breaking and ω\omega->ππ\pi\pi Decay

We study $\omega\to\pi^+\pi^-$ decay up to including all orders of the chiral expansion and one-loop level of mesons in formlism of chiral constituent quark model. This G-parity forbidden decay is caused by $m_u\neq m_d$ and electromagnetic interaction of mesons. We illustrate that in the formlism both nonresonant contact interaction and $\rho$ resonance exchange contribute to this process, and the contribution from $\rho$ resonance exchange is dominant. We obtain that transition matrix element is $=[-(3956\pm 280)-(1697\pm 130)i]$MeV$^2$, and isospin breaking parameter is $m_d-m_u=3.9\pm 0.22$MeV at energy scale $\mu\sim m_\omega$.Comment: Revtex file, 16 pages, four eps figur

Back Reaction of Strings in Self-Consistent String Cosmology

We compute the string energy-momentum tensor and {\bf derive} the string equation of state from exact string dynamics in cosmological spacetimes. $1+1,~2+1$ and $D$-dimensional universes are treated for any expansion factor $R$. Strings obey the perfect fluid relation $p = (\gamma -1) \rho$ with three different behaviours: (i) {\it Unstable} for $R \to \infty$ with growing energy density $\rho \sim R^{2-D}$, {\bf negative} pressure, and $\gamma =(D-2)/(D-1)$; (ii){\it Dual} for $R \to 0$, with $\rho \sim R^{-D}$, {\bf positive} pressure and $\gamma = D/(D-1)$ (as radiation); (iii) {\it Stable} for $R \to \infty$ with $\rho \sim R^{1-D}$, {\bf vanishing} pressure and $\gamma = 1$ (as cold matter). We find the back reaction effect of these strings on the spacetime and we take into account the quantum string decay through string splitting. This is achieved by considering {\bf self-consistently} the strings as matter sources for the Einstein equations, as well as for the complete effective string equations. String splitting exponentially suppress the density of unstable strings for large $R$. The self-consistent solution to the Einstein equations for string dominated universes exhibits the realistic matter dominated behaviour $R \sim (X^0)^{2/(D-1)}\;$ for large times and the radiation dominated behaviour $R \sim (X^0)^{2/D}\;$ for early times. De Sitter universe does not emerge as solution of the effective string equations. The effective string action (whatever be the dilaton, its potential and the central charge term) is not the appropriate framework in which to address the question of string driven inflation.Comment: 29 pages, revtex, LPTHE-94-2

Analyticity, Crossing Symmetry and the Limits of Chiral Perturbation Theory

The chiral Lagrangian for Goldstone boson scattering is a power series expansion in numbers of derivatives. Each successive term is suppressed by powers of a scale, $\Lambda_\chi$, which must be less than of order $4\pi f/\sqrt{N}$ where $f$ is the Goldstone boson decay constant and $N$ is the number of flavors. The chiral expansion therefore breaks down at or below $4 \pi f/\sqrt{N}$. We argue that the breakdown of the chiral expansion is associated with the appearance of physical states other than Goldstone bosons. Because of crossing symmetry, some ``isospin'' channels will deviate from their low energy behavior well before they approach the scale at which their low energy amplitudes would violate unitarity. We argue that the estimates of ``oblique'' corrections from technicolor obtained by scaling from QCD are untrustworthy.Comment: harvmac, 18 pages (3 figures), HUTP-92/A025, BUHEP-92-18, new version fixes a TeX problem in little mod

Neutron electric dipole moment: Constituent-dressing and compositeness

Contributions to the neutron's EDM, are calculated using a well-constrained Ansatz for the nucleon's Poincare' covariant Fadde'ev amplitude. The momentum-dependent quark dressing amplifies the contribution from the current-quarks' EDMs; and dressed-quark confinement and binding make distinguishable the effect of the two CP and T violating interactions: i gamma_5 sigma_{mu nu} (p_1-p_2)_nu and gamma_5 (p_1+p_2)_mu, where p_{1,2} are the current-quarks' momenta. The value of |d_n| obtained using the current-quark EDMs generated by a minimal three Higgs doublet model of spontaneous CP violation is close to the current experimental upper bound.Comment: 9 pages, LaTeX2e. Errors in Table 1 corrected; five references added. To appear in Phys. Rev.

Poincare Invariant Algebra From Instant to Light-Front Quantization

We present the Poincare algebra interpolating between instant and light-front time quantizations. The angular momentum operators satisfying SU(2) algebra are constructed in an arbitrary interpolation angle and shown to be identical to the ordinary angular momentum and Leutwyler-Stern angular momentum in the instant and light-front quantization limits, respectively. The exchange of the dynamical role between the transverse angular mometum and the boost operators is manifest in our newly constructed algebra.Comment: 21 pages, 3 figures, 1 tabl

Vector meson dominance and the rho meson

We discuss the properties of vector mesons, in particular the rho^0, in the context of the Hidden Local Symmetry (HLS) model. This provides a unified framework to study several aspects of the low energy QCD sector. Firstly, we show that in the HLS model the physical photon is massless, without requiring off field diagonalization. We then demonstrate the equivalence of HLS and the two existing representations of vector meson dominance, VMD1 and VMD2, at both tree level and one loop order. Finally the S matrix pole position is shown to provide a model and process independent means of specifying the rho mass and width, in contrast to the real axis prescription currently used in the Particle Data Group tables.Comment: 18 pages, REVTE