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Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes.
Recently, a severe combined immunodeficiency syndrome with a deficiency of CD8+ peripheral T cells and a TCR signal transduction defect in peripheral CD4+ T cells was associated with mutations in ZAP-70. Since TCR signaling is required in developmental decisions resulting in mature CD4 (and CD8) T cells, the presence of peripheral CD4+ T cells expressing TCRs incapable of signaling in these patients is paradoxical. Here, we show that the TCRs on thymocytes, but not peripheral T cells, from a ZAP-70-deficient patient are capable of signaling. Moreover, the TCR on a thymocyte line derived from this patient can signal, and the homologous kinase Syk is present at high levels and is tyrosine phosphorylated after TCR stimulation. Thus, Syk may compensate for the loss of ZAP-70 and account for the thymic selection of at least a subset of T cells (CD4+) in ZAP-70-deficient patients
The nature of submillimetre galaxies in cosmological hydrodynamic simulations
We study the nature of rapidly star-forming galaxies at z= 2 in cosmological hydrodynamic simulations, and compare their properties to observations of submillimetre galaxies (SMGs). We identify simulated SMGs as the most rapidly star-forming systems that match the observed number density of SMGs. In our models, SMGs are massive galaxies sitting at the centres of large potential wells, being fed by smooth infall and gas-rich satellites at rates comparable to their star formation rates (SFRs). They are not typically undergoing major mergers that significantly boost their quiescent SFR, but they still often show complex gas morphologies and kinematics. Our simulated SMGs have stellar masses of M*∼ 1011−11.7 M⊙, SFRs of ∼180–500 M⊙ yr−1, a clustering length of ∼10 h−1 Mpc and solar metallicities. The SFRs are lower than those inferred from far-infrared (far-IR) data by ∼×3, which we suggest may owe to one or more systematic effects in the SFR calibrations. SMGs at z= 2 live in ∼1013 M⊙ haloes, and by z= 0 they mostly end up as brightest group galaxies in ∼1014 M⊙ haloes. We predict that higher M* SMGs should have on average lower specific SFRs, less disturbed morphologies and higher clustering. We also predict that deeper far-IR surveys will smoothly join SMGs on to the massive end of the SFR–M* relationship defined by lower mass z∼ 2 galaxies. Overall, our simulated rapid star-formers provide as good a match to available SMG data as merger-based scenarios, offering an alternative scenario that emerges naturally from cosmological simulations
Teratoma of the anterior mediastinum presenting as a cystic neck mass: a case report
<p>Abstract</p> <p>Introduction</p> <p>Teratomas of anterior mediastinum are rare tumors and are often slow growing, asymptomatic and detected incidentally on chest imaging. Results of surgical resection are very satisfactory.</p> <p>Case presentation</p> <p>A 19-years old male presented with an asymptomatic cystic neck mass. X-ray and CT scan of chest and neck showed an extrathyroidal multi-septate, predominantly cystic neck mass, that was continuous with a solid intrathoracic mass extending up to the level of right atrium and which contained areas of calcification and cystic necrosis. The mediastinal structures did not show any features of compression or infiltration. Fine needle aspiration cytology from the neck mass was suggestive of a dermoid cyst. In view of the extent and uncertain pathological nature of the tumor, it was excised via a combined cervical and trans-sternal route. Histo-pathology of the resected specimen confirmed the diagnosis of a mature cystic teratoma. The patient made an uneventful recovery, and after five years of follow-up, he has been symptom free with no clinical or radiological evidence of recurrent disease. We discuss the role of imaging and the need for surgical treatment to avoid possible catastrophic complications in patients with cervical and mediastinal masses of uncertain histological nature.</p> <p>Conclusion</p> <p>A mediastinal teratoma may rarely present as a cystic neck swelling due to its cephalad extension. This entity needs to be considered in cases where clinical and investigative work-up fail to provide a convincing clue to a primary neck pathology as cause of a cystic neck swelling.</p
Four-nucleon contact interactions from holographic QCD
We calculate the low energy constants of four-nucleon interactions in an
effective chiral Lagrangian in holographic QCD. We start with a D4-D8 model to
obtain meson-nucleon interactions and then integrate out massive mesons to
obtain the four-nucleon interactions in 4D. We end up with two low energy
constants at the leading order and seven of them at the next leading order,
which is consistent with the effective chiral Lagrangian. The values of the low
energy constants are evaluated with the first five Kaluza-Klein resonances.Comment: 28 page
Emergent Gauge Fields in Holographic Superconductors
Holographic superconductors have been studied so far in the absence of
dynamical electromagnetic fields, namely in the limit in which they coincide
with holographic superfluids. It is possible, however, to introduce dynamical
gauge fields if a Neumann-type boundary condition is imposed on the
AdS-boundary. In 3+1 dimensions, the dual theory is a 2+1 dimensional CFT whose
spectrum contains a massless gauge field, signaling the emergence of a gauge
symmetry. We study the impact of a dynamical gauge field in vortex
configurations where it is known to significantly affect the energetics and
phase transitions. We calculate the critical magnetic fields H_c1 and H_c2,
obtaining that holographic superconductors are of Type II (H_c1 < H_c2). We
extend the study to 4+1 dimensions where the gauge field does not appear as an
emergent phenomena, but can be introduced, by a proper renormalization, as an
external dynamical field. We also compare our predictions with those arising
from a Ginzburg-Landau theory and identify the generic properties of Abrikosov
vortices in holographic models.Comment: 19 pages, 14 figures, few comments added, version published in JHE
Massive benign pericardial cyst presenting with simultaneous superior vena cava and middle lobe syndromes
A 66 year old woman presented in extremis with symptoms and clinical and radiological signs of simultaneous obstruction of superior vena cava and middle lobe of right lung secondary to compression by a massive benign anterior mediastinal cyst. Excision of the cyst at median sternotomy resulted in complete resolution of all symptoms. This report is unusual on account of a) the concomitant presence of superior vena cava and middle lobe syndromes caused by a benign cyst because of its sheer size producing obstruction of these structures and b) the complete resolution of all symptoms and signs after removal of the cyst. Benign anterior mediastinal cysts are unknown to cause either of the two syndromes. To our knowledge, it is the first report of a benign anterior mediastinal cyst causing either superior vena cava syndrome or middle lobe syndrome or both simultaneously. Etiologies of both superior vena cava and middle lobe syndromes are discussed in detail
Fluids in cosmology
We review the role of fluids in cosmology by first introducing them in
General Relativity and then by applying them to a FRW Universe's model. We
describe how relativistic and non-relativistic components evolve in the
background dynamics. We also introduce scalar fields to show that they are able
to yield an inflationary dynamics at very early times (inflation) and late
times (quintessence). Then, we proceed to study the thermodynamical properties
of the fluids and, lastly, its perturbed kinematics. We make emphasis in the
constrictions of parameters by recent cosmological probes.Comment: 34 pages, 4 figures, version accepted as invited review to the book
"Computational and Experimental Fluid Mechanics with Applications to Physics,
Engineering and the Environment". Version 2: typos corrected and references
expande
Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes. At present, very little is known about the role of gene-environment interactions in modulating craniosynostosis phenotypes, but prior evidence suggests a role for endocrine factors. Here we provide a report of the effects of thyroid hormone exposure on murine calvaria cells. Murine derived calvaria cells were exposed to critical doses of pharmaceutical thyroxine and analyzed after 3 and 7 days of treatment. Endpoint assays were designed to determine the effects of the hormone exposure on markers of osteogenesis and included, proliferation assay, quantitative ALP activity assay, targeted qPCR for mRNA expression of Runx2, Alp, Ocn, and Twist1, genechip array for 28,853 targets, and targeted osteogenic microarray with qPCR confirmations. Exposure to thyroxine stimulated the cells to express ALP in a dose dependent manner. There were no patterns of difference observed for proliferation. Targeted RNA expression data confirmed expression increases for Alp and Ocn at 7 days in culture. The genechip array suggests substantive expression differences for 46 gene targets and the targeted osteogenesis microarray indicated 23 targets with substantive differences. 11 gene targets were chosen for qPCR confirmation because of their known association with bone or craniosynostosis (Col2a1, Dmp1, Fgf1, 2, Igf1, Mmp9, Phex, Tnf, Htra1, Por, and Dcn). We confirmed substantive increases in mRNA for Phex, FGF1, 2, Tnf, Dmp1, Htra1, Por, Igf1 and Mmp9, and substantive decreases for Dcn. It appears thyroid hormone may exert its effects through increasing osteogenesis. Targets isolated suggest a possible interaction for those gene products associated with calvarial suture growth and homeostasis as well as craniosynostosis. © 2013 Cray et al
Cooling of Dark-Matter Admixed Neutron Stars with density-dependent Equation of State
We propose a dark-matter (DM) admixed density-dependent equation of state
where the fermionic DM interacts with the nucleons via Higgs portal. Presence
of DM can hardly influence the particle distribution inside neutron star (NS)
but can significantly affect the structure as well as equation of state (EOS)
of NS. Introduction of DM inside NS softens the equation of state. We explored
the effect of variation of DM mass and DM Fermi momentum on the NS EOS.
Moreover, DM-Higgs coupling is constrained using dark matter direct detection
experiments. Then, we studied cooling of normal NSs using APR and DD2 EOSs and
DM admixed NSs using dark-matter modified DD2 with varying DM mass and Fermi
momentum. We have done our analysis by considering different NS masses. Also DM
mass and DM Fermi momentum are varied for fixed NS mass and DM-Higgs coupling.
We calculated the variations of luminosity and temperature of NS with time for
all EOSs considered in our work and then compared our calculations with the
observed astronomical cooling data of pulsars namely Cas A, RX J0822-43, 1E
1207-52, RX J0002+62, XMMU J17328, PSR B1706-44, Vela, PSR B2334+61, PSR
B0656+14, Geminga, PSR B1055-52 and RX J0720.4-3125. It is found that APR EOS
agrees well with the pulsar data for lighter and medium mass NSs but cooling is
very fast for heavier NS. For DM admixed DD2 EOS, it is found that for all
considered NS masses, all chosen DM masses and Fermi momenta agree well with
the observational data of PSR B0656+14, Geminga, Vela, PSR B1706-44 and PSR
B2334+61. Cooling becomes faster as compared to normal NSs in case of
increasing DM mass and Fermi momenta. It is infered from the calculations that
if low mass super cold NSs are observed in future that may support the fact
that heavier WIMP can be present inside neutron stars.Comment: 24 Pages, 15 Figures and 2 Tables. Version accepted in The European
Physical Journal
Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events
Peer reviewedPublisher PD
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