Dose-dependent new bone formation by extracorporeal shock wave application on the intact femur of rabbits

Background: Whereas various molecular working mechanisms of shock waves have been demonstrated, no study has assessed in detail the influence of varying energy flux densities (EFD) on new bone formation in vivo. Methods: Thirty Chinchilla bastard rabbits were randomly assigned to 5 groups (EFD 0.0, 0.35, 0.5, 0.9 and 1.2 mJ/mm(2)) and treated with extracorporeal shock waves at the distal femoral region (1,500 pulses; 1 Hz frequency). To investigate new bone formation, animals were injected with oxytetracycline at days 5-9 after shock wave application and sacrificed on day 10. Histological sections of all animals were examined using broad-band epifluorescent illumination, contact microradiography and Giemsa-Eosin staining. Results: Application of shock waves induced new bone formation beginning with 0.5 mJ/mm(2) EFD and increasing with 0.9 mJ/mm(2) and 1.2 mJ/mm(2). The latter EFD resulted in new bone formation also on the dorsal cortical bone; cortical fractures and periosteal detachment also occurred. Conclusion: Here, for the first time, a threshold level is presented for new bone formation after applying shock waves to intact bone in vivo. The findings of this study are of considerable significance for preventing unwanted side effects in new approaches in the clinical application of shock waves. Copyright (c) 2008 S. Karger AG, Basel

Recent Type II Radio Supernovae

We present the results of radio observations, taken primarily with the Very Large Array, of Supernovae 1993J, 2001gd, 2001em, 2002hh, 2004dj, and 2004et. We have fit a parameterized model to the multi-frequency observations of each supernova. We compare the observed and derived radio properties of these supernovae by optical classification and discuss the implications.Comment: 5 pages, 2 figures, 1 table Conference Proceedings: "Supernova 1987A: 20 Years After: Supernovae and Gamma-Ray Bursters" AIP, New York, eds. S. Immler, K.W. Weiler, and R. McCra

LHC Cleaning Efficiency with Imperfections

The performance reach of the LHC depends on the magnitude of beam losses and the achievable cleaning efficiency of its collimation system. The ideal performance reach for the nominal Phase 1 collimation system is reviewed. However, unavoidable imperfections affect any accelerator and can further deteriorate the collimation performance. Multiple static machine and collimator imperfections were included in the LHC tracking simulations. Error models for collimator jaw flatness, collimator setup accuracy, the LHC orbit and the LHC aperture were set up, based to the maximum extent possible on measurements and results of experimental beam tests. It is shown that combined “realistic” imperfections can reduce the LHC cleaning efficiency by about a factor 11 on average

Beam Commissioning Plan For LHC Collimation

The Large Hadron Collider extends the present state-of-the-art in stored beam energy by 2-3 orders of magnitude. A sophisticated system of collimators is implemented along the 27 km ring and mainly in two dedicated cleaning insertions, to intercept and absorb unavoidable beam losses which could induce quenches in the superconducting (sc) magnets. 88 collimators for the two beams are initially installed for the so called Phase 1. An optimized strategy for the commissioning of this considerable number of collimators has been defined. This optimized strategy maximizes cleaning efficiency and tolerances available for operation, while minimizing the required beam time for collimator setup and ensuring at all times the required passive machine protection. It is shown that operational tolerances from collimation can initially be significantly relaxed

End of the cosmic neutrino energy spectrum

There may be a high-energy cutoff of neutrino events in IceCube data. In particular, IceCube does not observe either continuum events above 2 PeV, or the Standard Model Glashow-resonance events expected at 6.3 PeV. There are also no higher energy neutrino signatures in the ANITA and Auger experiments. This absence of high-energy neutrino events motivates a fundamental restriction on neutrino energies above a few PeV. We postulate a simple scenario to terminate the neutrino spectrum that is Lorentz-invariance violating, but with a limiting neutrino velocity that is always smaller than the speed of light. If the limiting velocity of the neutrino applies also to its associated charged lepton, then a significant consequence is that the two-body decay modes of the charged pion are forbidden above two times the maximum neutrino energy, while the radiative decay modes are suppressed at higher energies. Such stabilized pions may serve as cosmic ray primaries.Comment: 6 pages. Version to appear in PL

Form and function in hillslope hydrology : Characterization of subsurface ow based on response observations

Acknowledgements. We are grateful to Marcel Delock, Lisei Köhn, and Marvin Reich for their support during fieldwork, as well as Markus Morgner and Jean Francois Iffly for technical support, Britta Kattenstroth for hydrometeorological data acquisition and isotope sampling, and Barbara Herbstritt and Begoña Lorente Sistiaga for laboratory work. Laurent Pfister and Jean-Francois Iffly from the Luxembourg Institute of Science and Technology (LIST) are acknowledged for organizing the permissions for the experiments and providing discharge data for Weierbach 1 and Colpach. We also want to thank Frauke K. Barthold and the two anonymous reviewers, whose thorough remarks greatly helped to improve the manuscript. This study is part of DFG-funded CAOS project “From Catchments as Organised Systems to Models based on Dynamic Functional Units” (FOR 1598). The article processing charges for this open-access publication were covered by a Research Centre of the Helmholtz Association.Peer reviewedPublisher PD

All-Optical Switching Demonstration using Two-Photon Absorption and the Classical Zeno Effect

Low-contrast all-optical Zeno switching has been demonstrated in a silicon nitride microdisk resonator coupled to a hot atomic vapor. The device is based on the suppression of the field build-up within a microcavity due to non-degenerate two-photon absorption. This experiment used one beam in a resonator and one in free-space due to limitations related to device physics. These results suggest that a similar scheme with both beams resonant in the cavity would correspond to input power levels near 20 nW.Comment: 4 pages, 5 figure

Acoustically driven ferromagnetic resonance

Surface acoustic waves (SAW) in the GHz frequency range are exploited for the all-elastic excitation and detection of ferromagnetic resonance (FMR) in a ferromagnetic/ferroelectric (nickel/lithium niobate) hybrid device. We measure the SAW magneto-transmission at room temperature as a function of frequency, external magnetic field magnitude, and orientation. Our data are well described by a modified Landau-Lifshitz-Gilbert approach, in which a virtual, strain-induced tickle field drives the magnetization precession. This causes a distinct magnetic field orientation dependence of elastically driven FMR that we observe in both model and experiment.Comment: 4 page

Results of the studies on energy deposition in IR6 superconducting magnets from continuous beam loss on the TCDQ system

A single sided mobile graphite diluter block TCDQ, in combination with a two-sided secondary collimator TCS and an iron shield TCDQM, will be installed in front of the superconducting quadrupole Q4 magnets in IR6, in order to protect it and other downstream LHC machine elements from destruction in the event of a beam dump that is not synchronised with the abort gap. The TCDQ will be positioned close to the beam, and will intercept the particles from the secondary halo during low beam lifetime. Previous studies (1-4) have shown that the energy deposited in the Q4 magnet coils can be close to or above the quench limit. In this note the results of the latest FLUKA energy deposition simulations for Beam 2 are described, including an upgrade possibility for the TCDQ system with an additional shielding device. The results are discussed in the context of the expected performance levels for the different phases of LHC operation