Integrating Globalization into the Social Work Curriculum

The reality that social work is a global profession is explored. Authors encourage a broadening of social work education, moving beyond the traditional conception of internationalized to a globalized social work curriculum. Practical teaching strategies for a globalized perspective are presented with selected key concepts specifically applied to social policy, community practice, human behavior in the social environment, and sustainable development. Discussion includes macro-scale ethical considerations in a neoliberal economic system

Bone Marrow Transplantation for Feline Mucopolysaccharidosis I

Severe mucopolysaccharidosis type I (MPS I) is a fatal neuropathic lysosomal storage disorder with significant skeletal involvement. Treatment involves bone marrow transplantation (BMT), and although effective, is suboptimal, due to treatment sequelae and residual disease. Improved approaches will need to be tested in animal models and compared to BMT. Herein we report on bone marrow transplantation to treat feline mucopolysaccharidosis I (MPS I). Five MPS I stably engrafted kittens, transplanted with unfractionated bone marrow (6.3 × 107–1.1 × 109 nucleated bone marrow cells per kilogram) were monitored for 13–37 months post-engraftment. The tissue total glycosaminoglycan (GAG) content was reduced to normal levels in liver, spleen, kidney, heart muscle, lung, and thyroid. Aorta GAG content was between normal and affected levels. Treated cats had a significant decrease in the brain GAG levels relative to untreated MPS I cats and a paradoxical decrease relative to normal cats. The α-l-iduronidase (IDUA) activity in the livers and spleens of transplanted MPS I cats approached heterozygote levels. In kidney cortex, aorta, heart muscle, and cerebrum, there were decreases in GAG without significant increases in detectable IDUA activity. Treated animals had improved mobility and decreased radiographic signs of disease. However, significant pathology remained, especially in the cervical spine. Corneal clouding appeared improved in some animals. Immunohistochemical and biochemical analysis documented decreased central nervous system ganglioside storage. This large animal MPS I study will serve as a benchmark of future therapies designed to improve on BMT

Integrating Globalization Into The Social Work Curriculum

The reality that social work is a global profession is explored. Authors encourage a broadening of social work education, moving beyond the traditional conception of internationalized to a globalized social work curriculum. Practical teaching strategies for a globalized perspective are presented with selected key concepts specifically applied to social policy, community practice, human behavior in the social environment, and sustainable development. Discussion includes macro-scale ethical considerations in a neoliberal economic system