The DMSP/MFR total ozone and radiance data base

This report describes the entries in sufficient detail so that the data base might be useful to others. The characteristics of the MFR sensor are briefly discussed and a complete index to the data base tapes is given

Apparatus to control and visualize the impact of a high-energy laser pulse on a liquid target

We present an experimental apparatus to control and visualize the response of a liquid target to a laser-induced vaporization. We use a millimeter-sized drop as target and present two liquid-dye solutions that allow a variation of the absorption coefficient of the laser light in the drop by seven orders of magnitude. The excitation source is a Q-switched Nd:YAG laser at its frequency-doubled wavelength emitting nanosecond pulses with energy densities above the local vaporization threshold. The absorption of the laser energy leads to a large-scale liquid motion at timescales that are separated by several orders of magnitude, which we spatiotemporally resolve by a combination of ultra-high-speed and stroboscopic high-resolution imaging in two orthogonal views. Surprisingly, the large-scale liquid motion at upon laser impact is completely controlled by the spatial energy distribution obtained by a precise beam-shaping technique. The apparatus demonstrates the potential for accurate and quantitative studies of laser-matter interactions.Comment: Submitted to Review of Scientific Instrument

Light amplification without stimulated emission: Beyond the standard quantum limit to the laser linewidth

The standard quantum limit to the linewidth of a laser for which the gain medium can be adiabatically eliminated is l(0) = K/2 (n) over bar Here K is the intensity damping rate and (n) over bar the mean photon number. This contains equal contributions from the loss and gain processes, so that simple arguments which attribute the linewidth wholly to phase noise from spontaneous gain are wrong. I show that an unstimulated gain process actually introduces no phase noise, so that the ultimate quantum limit to the linewidth comes from the loss alone and is equal to l(ult) = K/4 (n) over bar. I investigate a number of physical gain mechanisms which attempt to achieve gain without phase noise: a linear atom-field coupling with a finite interaction time, a nonlinear atom-field coupling, and adiabatic photon transfer using a counterintuitive pulse sequence. The first at best reaches the standard limit l(0), the second reaches 3/4l(0), and the third reaches the ultimate limit of l(ult)= 1/2l(0). [S1050-2947(99)03711-7]

Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans

<p>Abstract</p> <p>Background</p> <p>Dysfunctions in the serotonergic system have been implicated in several neurological disorders such as depression. Elderly individuals who have been diagnosed with clinical depression show elevated cases of neurodegenerative diseases. This has led to suggestions that modulating the serotonin (5-HT) system could provide an alternative method to current therapies for alleviating these pathologies. The neuroprotective effects of bilobalide <it>in vitro </it>have been documented. We aim to determine whether bilobalide affects the 5-HT system in the nematode <it>C. elegans</it>. The wild type worms, as well as well-characterized 5-HT mutants, were fed with bilobalide in a range of concentrations, and several 5-HT controlled behaviors were tested.</p> <p>Results</p> <p>We observed that bilobalide significantly inhibited 5-HT-controlled egg-laying behavior in a dose-dependent manner, which was blocked in the 5-HT receptor mutants (<it>ser-4, mod-1</it>), but not in the 5-HT transporter (<it>mod-5</it>) or synthesis (<it>tph-1</it>) mutants. Bilobalide also potentiated a 5-HT-controlled, experience-dependent locomotory behavior, termed the enhanced slowing response in the wild type animals. However, this effect was fully blocked in 5-HT receptor <it>mod-1 </it>and dopamine defective <it>cat-2 </it>mutants, but only partially blocked in <it>ser-4 </it>mutants. We also demonstrated that acetylcholine transmission was inhibited in a transgenic <it>C. elegans </it>strain that constitutively expresses Aβ, and bilobalide did not significantly affect this inhibition.</p> <p>Conclusion</p> <p>These results suggest that bilobalide may modulate specific 5-HT receptor subtypes, which involves interplay with dopamine transmission. Additional studies for the function of bilobalide in neurotransmitter systems could aid in our understanding of its neuroprotective properties.</p

Brachypodium distachyon as a model for defining the allergen potential of non-prolamin proteins

Epitope databases and the protein sequences of published plant genomes are suitable to identify some of the proteins causing food allergies and sensitivities. Brachypodium distachyon, a diploid wild grass with a sequenced genome and low prolamin content, is the closest relative of the allergen cereals, such as wheat or barley. Using the Brachypodium genome sequence, a workflow has been developed to identify potentially harmful proteins which may cause either celiac disease or wheat allergy-related symptoms. Seed tissue-specific expression of the potential allergens has been determined, and intact epitopes following an in silico digestion with several endopeptidases have been identified. Molecular function of allergen proteins has been evaluated using Gene Ontology terms. Biologically overrepresented proteins and potentially allergen protein families have been identified. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s10142-012-0294-z) contains supplementary material, which is available to authorized users

Regional wind-field study in complex terrain during summer sea-breeze conditions

A regional-scale data base, consisting of wind and temperature data for June and July of 1977, was developed for the greater San Francisco Bay Area and eastward to the Central Valley. Continuous meteorological measurements were made in the area of a windy pass (Patterson Pass) 3 km east of Lawrence Livermore Laboratory. This area was chosen because of its complex terrain and importance as a downwind topographic feature affecting the dispersal of possible accidental atmospheric releases from the Laboratory and as an area of high wind-energy potential. The results of this study provided the following: (1) a data base, including over 50 stations for use in numerical wind-field regional-scale-model validation; (2) characterization of summer sea breese oscillations of approx. 6 and 12 days (this analysis is useful in calculating wind-power persistence and in understanding summer sea-breeze mechanisms in the Bay Area); and (3) successful application of an optical space-averaging wind sensor over a 1-km path across a pass to provide long-path averaged data more suitable for regional, numerical wind-field models with kilometre-size grid elements

Total ozone retrieval from satellite multichannel filter radiometer measurements

A total ozone retrieval model has been developed to process radiance data gathered by a satellite-mounted multichannel filter radiometer (MFR). Extensive effort went into theoretical radiative transfer modeling, a retrieval scheme was developed, and the technique was applied to the MFR radiance measurements. The high quality of the total ozone retrieval results was determined through comparisons with Dobson measurements. Included in the report are global total ozone maps for 20 days between May 12 and July 5, 1977. A comparison of MFR results for 13 days in June 1977 with Dobson spectrophotometer measurements of ozone for the same period showed good agreement: there was a root-mean-square difference of 6.2% (equivalent to 20.2 m.atm.cm). The estimated global total ozone value for June 1977 (296 m.atm.cm) was in good agreement with satellite backscatter ultraviolet data for June 1970 (304 m.atm.cm) and June 1971 (preliminary data--299 m.atm.cm)