Profile control charts based on nonparametric LL-1 regression methods

Classical statistical process control often relies on univariate characteristics. In many contemporary applications, however, the quality of products must be characterized by some functional relation between a response variable and its explanatory variables. Monitoring such functional profiles has been a rapidly growing field due to increasing demands. This paper develops a novel nonparametric $L$-1 location-scale model to screen the shapes of profiles. The model is built on three basic elements: location shifts, local shape distortions, and overall shape deviations, which are quantified by three individual metrics. The proposed approach is applied to the previously analyzed vertical density profile data, leading to some interesting insights.Comment: Published in at http://dx.doi.org/10.1214/11-AOAS501 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

A virtual time CSMA protocols for hard real-time communication

We study virtual time CSMA protocols for hard real time communication systems where messages have explicit deadlines. In this protocol, each node maintains two clocks; a real time clock and a virtual time clock. Whenever a node finds the channel to be idle, it resets its virtual clock to be equal to the real clock. The virtual clock then runs at a higher rate than the real clock. A node transmits a waiting message when the time on the virtual clock is equal to the latest time to send the message. This protocol implements the minimum-laxity-first transmission policy. We compare the performance of our protocol with two baseline protocols both of which transmit messages according to the minimum-laxity-first policy. While both use perfect state information about the nodes and channel, the first is an idealized protocol which obtains this information without paying any cost and the second one pays a reasonable price for it. The simulation study shows that in most cases, our protocol performs close to the first one and better than the second one

Production of dihydroxyacetone from glycerol by engineered Escherichia coli cells co-expressing gldA and nox genes

Glycerol can be converted into more valuable compound dihydroxyacetone by the nicotinamide adenine dinucleotide (NAD+)-dependent glycerol dehydrogenase. However, it is economically prohibitive to produce dihydroxyacetone using purified glycerol dehydrogenase at the expense of a stoichiometric amount of the cofactor NAD+. In this study, Escherichia coli was engineered for dihydroxyacetone production by enhancing its glycerol dehydrogenase activity and introducing NADH oxidase activity. Under optimized conditions, dihydroxyacetone productivity reached 0.13 g/h/g wet cell mass by recombinant E. coli D4 (pET-24b-gldA+nox) cells co-expressing gldA gene from E. coli and nox gene from Enterococcus faecalis. It was interesting to note that exogenous NAD+ greatly improved dihydroxyacetone production for the whole-cell biotransformation process. These results should be useful for the development of advanced bioprocess in terms of glycerol utilization.Keywords: Dihydroxyacetone, Glycerol dehydrogenase, NAD+, whole-cell biotransformation, Escherichia coliAfrican Journal of Biotechnology Vol. 12(27), pp. 4387-439

Structural and functional abnormities of amygdala and prefrontal cortex in major depressive disorder with suicide attempts

Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation and the pathogenesis of MDD. The aim of this study was to identify whether patients with MDD who had a history of SA show structural and functional connectivity abnormalities in the amygdala and PFC relative to MDD patients without a history of SA. We measured gray matter volume in the amygdala and PFC and amygdala-PFC functional connectivity using structural and functional magnetic resonance imaging (MRI) in 158 participants [38 MDD patients with a history of SA, 60 MDD patients without a history of SA, and 60 healthy control (HC)]. MDD patients with a history of SA had decreased gray matter volume in the right and left amygdala (F = 30.270, P = 0.000), ventral/medial/dorsal PFC (F = 15.349, P = 0.000), and diminished functional connectivity between the bilateral amygdala and ventral and medial PFC regions (F = 22.467, P = 0.000), compared with individuals who had MDD without a history of SA, and the HC group. These findings provide evidence that the amygdala and PFC may be closely related to the pathogenesis of suicidal behavior in MDD and implicate the amygdala-ventral/medial PFC circuit as a potential target for suicide intervention

Structural and functional abnormities of amygdala and prefrontal cortex in major depressive disorder with suicide attempts

Finding neural features of suicide attempts (SA) in major depressive disorder (MDD) may be helpful in preventing suicidal behavior. The ventral and medial prefrontal cortex (PFC), as well as the amygdala form a circuit implicated in emotion regulation and the pathogenesis of MDD. The aim of this study was to identify whether patients with MDD who had a history of SA show structural and functional connectivity abnormalities in the amygdala and PFC relative to MDD patients without a history of SA. We measured gray matter volume in the amygdala and PFC and amygdala-PFC functional connectivity using structural and functional magnetic resonance imaging (MRI) in 158 participants [38 MDD patients with a history of SA, 60 MDD patients without a history of SA, and 60 healthy control (HC)]. MDD patients with a history of SA had decreased gray matter volume in the right and left amygdala (F = 30.270, P = 0.000), ventral/medial/dorsal PFC (F = 15.349, P = 0.000), and diminished functional connectivity between the bilateral amygdala and ventral and medial PFC regions (F = 22.467, P = 0.000), compared with individuals who had MDD without a history of SA, and the HC group. These findings provide evidence that the amygdala and PFC may be closely related to the pathogenesis of suicidal behavior in MDD and implicate the amygdala-ventral/medial PFC circuit as a potential target for suicide intervention

Thick branes with a nonminimally coupled bulk-scalar field

In this paper, we investigate thick branes with a nonminimally coupled background scalar field, whose solution is a single-kink or a double-kink. The effects of the nonminimal coupling constant $\xi$ on the structure of the thick branes and the localization of gravity, fermions, scalars and vectors are discussed. It is shown that each brane will split into two sub-branes as increasing the nonminimal coupling constant $\xi$. By investigating the tensor perturbation equations of gravity and the general covariant Dirac equation of fermions, we find that both the gravity zero mode and left-chiral fermion zero mode are localized at the center of the single-kink branes and localized between the two sub-branes generated by the double-kink, which indicates that the constant $\xi$ does not effect the localization of these zero modes. However, the zero mode of scalars is localized on each sub-brane (for both single-kink and double-kink branes) when $\xi$ is larger than its critical value $\xi_0$. The effects of the nonminimal coupling constant $\xi$ on the resonances of gravity and fermions with finite lifetime on the branes are also discussed.Comment: V2: 33 pages, 17 figures, 3 tables, published versio