73 research outputs found
ΠΠΎΠ΄Ρ ΠΎΠ΄ ΠΊ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π±Π°Π· Π΄Π°Π½Π½ΡΡ , ΠΎΡΠ½ΠΎΠ²Π°Π½Π½ΡΠΉ Π½Π° Π°Π»Π³ΠΎΡΠΈΡΠΌΠ°Ρ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠΎΡΡΠ΅ΠΆΠ΅ΠΉ
ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½Π°Ρ ΠΌΠΎΠ΄Π΅Π»Ρ ΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ Π±Π°Π·Ρ Π΄Π°Π½Π½ΡΡ
, Π² ΠΎΡΠ½ΠΎΠ²Π΅ ΠΊΠΎΡΠΎΡΠΎΠΉ Π»Π΅ΠΆΠΈΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ² Π² Π²ΠΈΠ΄Π΅ Π΄Π΅ΡΠ΅Π²ΡΠ΅Π² Π-ΠΠΠ. Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΡΠ΅ Π°Π»Π³ΠΎΡΠΈΡΠΌΡ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΠΈ ΠΈ ΠΈΠ΄Π΅Π½ΡΠΈΡΠΈΠΊΠ°ΡΠΈΠΈ ΠΊΠΎΡΡΠ΅ΠΆΠ΅ΠΉ. ΠΠΎΠΊΠ°Π·Π°Π½Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠΆΠ°ΡΠΈΡ Π±Π°Π·Ρ Π΄Π°Π½Π½ΡΡ
ΠΏΡΠΈ Π½Π΅Π±ΠΎΠ»ΡΡΠΈΡ
Π·Π½Π°ΡΠ΅Π½ΠΈΡΡ
ΠΌΠΎΡΠ½ΠΎΡΡΠ΅ΠΉ Π΄ΠΎΠΌΠ΅Π½ΠΎΠ²
Β«ΠΠΠ€ΠΠΠΠΠΠΠΠΠΠΠΠ§ΠΠΒ» ΠΠΠΠ¦ΠΠΠ¦ΠΠ― ΠΠ ΠΠΠ’ΠΠΠ Π―Π Π’ΠΠ ΠΠΠ― Π ΠΠΠΠΠ’ΠΠ£Π€ΠΠΠΠΠΠΠΠΠΠΠΠ Π’Π ΠΠΠ‘ΠΠΠΠΠΠΠ Π₯ΠΠ₯- Π₯Π₯Π‘Π’ΠΠΠΠ’Π’Π―
Π ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΈ Π°Π²ΡΠΎΡ Π°Π½Π°Π»ΠΈΠ·ΠΈΡΡΠ΅Ρ ΡΠΌΠΏΠΈΡΠΈΡΠ΅ΡΠΊΡΡ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΡΡ Π€.
ΠΡΠ΅Π½ΡΠ°Π½ΠΎ, Π² ΡΠ°ΡΡΠ½ΠΎΡΡΠΈ, ΠΏΡΠΎΡΠ΅ΡΡ ΠΊΠΎΠ½ΡΡΠΈΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΡΠ½Π΅ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²Π΅Π½Π½ΡΡ
Π΄Π°Π½Π½ΠΎΡΡΠ΅ΠΉβ Π²Π½ΡΡΡΠ΅Π½Π½Π΅Π΅
ΡΡΡΠ΅ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠ΅Π΄ΠΌΠ΅ΡΠ°. Π’Π°ΠΊΠΎΠΉ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ ΡΡΠ°Π» Π½ΠΎΠ²ΡΠΌ Π°ΠΊΡΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Β«ΡΠΌΠΏΠΈΡΠΈΡΠ½ΠΎΡΡΠΈΒ» ΠΈ
ΠΏΠΎΠΏΡΡΠΊΠΎΠΉ Π²ΠΎΠ·ΠΎΠ±Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠΈΠ»ΠΎΡΠΎΡΠΈΠ΅ΠΉ ΠΈ ΠΏΡΠΈΡ
ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ ΠΏΠΎΠ½ΡΡΠΈΡ
Β«ΠΈΠ½ΡΠ΅Π½ΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΡΡΡΒ», ΠΊΠΎΡΠΎΡΠΎΠ΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΠΊΠΎ-ΠΏΠΎΠ·Π½Π°Π²Π°ΡΠ΅Π»ΡΠ½ΡΠΌ ΠΏΡΠΈΠ½ΡΠΈΠΏΠΎΠΌ.In this investigation author analyses empirical psychology of F.Brentano βthe procces of constitute
spontaneous facts as inside existence the object.
This idea have an influence development of the transcendental phenomenology, hermeneutical
phenomenology and have be essential for development of the contemporary philosophy of the value
Π‘ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ°Π±ΠΎΡΠΈΡ ΠΊΠ°Π΄ΡΠΎΠ² Π² ΡΠ°ΠΌΠΊΠ°Ρ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π Π€
Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΏΡΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΠΈ ΠΏΠ΅ΡΠ΅ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΡΠ°Π±ΠΎΡΠΈΡ
ΠΊΠ°Π΄ΡΠΎΠ² Π² ΡΡΠ΅ΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΌΠ΅ΡΡ ΠΏΠΎ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ ΠΊΠΎΠ½ΠΊΡΡΠ΅Π½ΡΠΎΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠ΅ ΡΠ°Π±ΠΎΡΠΈΡ
ΠΊΠ°Π΄ΡΠΎΠ²
Technique of definition of cracking resistance characteristics of metal plates and envelopes of small thickness
The technique of cracking resistance tests of metal plates of small thickness is given. Features of such tests, among which are occurrence of warp in the places of fastening of plates, occurrence of waves because of loss of stability at out-centre loading are shown. Ways to eliminate these shortcomings with the help of special equipment are specified. Tests by the proposed methods allow to make recommendations for technology and choice of steels at creation of valve tapes
REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer
Purpose: REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data.
Methods: An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially curable radiotherapy. Radiotherapy was prescribed according to local regimens, but centres used standardised data collection forms. Pre-treatment blood samples were collected. Patients were followed for a minimum of 12 (lung) or 24 (breast/prostate) months and summary descriptive statistics were generated.
Results: The study recruited 2069 breast (99% of target), 1808 prostate (86%) and 561 lung (51%) cancer patients. The centralised, accessible database includes: physician-(47,025 forms) and patient-(54,901) reported outcomes; 11,563 breast photos; 17,107 DICOMs and 12,684 DVHs. Imputed genotype data are available for 4223 patients with European ancestry (1948 breast, 1728 prostate, 547 lung). Radiation-induced lymphocyte apoptosis (RILA) assay data are available for 1319 patients. DNA (n = 4409) and PAXgene tubes (n = 3039) are stored in the centralised biobank. Example prevalences of 2-year (1-year for lung) grade >= 2 CTCAE toxicities are 13% atrophy (breast), 3% rectal bleeding (prostate) and 27% dyspnoea (lung).
Conclusion: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers.
Patient summary: Up to half of cancer patients undergo radiation therapy and irradiation of surrounding healthy tissue is unavoidable. Damage to healthy tissue can affect short-and long-term quality-of-life. Not all patients are equally sensitive to radiation "damage" but it is not possible at the moment to identify those who are. REQUITE was established with the aim of trying to understand more about how we could predict radiation sensitivity. The purpose of this paper is to provide an overview and summary of the data and material available.
In the REQUITE study 4400 breast, prostate and lung cancer patients filled out questionnaires and donated blood. A large amount of data was collected in the same way. With all these data and samples a database and biobank were created that showed it is possible to collect this kind of information in a standardised way across countries.
In the future, our database and linked biobank will be a resource for research and validation of clinical predictors and models of radiation sensitivity. REQUITE will also enable a better understanding of how many people suffer with radiotherapy toxicity
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