Подход к созданию баз данных, основанный на алгоритмах генерации и идентификации кортежей

Предложена оригинальная модель реляционной базы данных, в основе которой лежит представление доменов в виде деревьев И-ИЛИ. Разработаны оригинальные алгоритмы генерации и идентификации кортежей. Показана возможность существенного сжатия базы данных при небольших значениях мощностей доменов

«ДОФЕНОМЕНОЛОГІЧНА» КОНЦЕПЦІЯ БРЕНТАНО ЯК ТЛО ДЛЯ РОЗВИТКУФЕНОМЕНОЛОГІЇ ТА АКСІОЛОГІЇ ХІХ- ХХСТОЛІТТЯ

В представленном исследовании автор анализирует эмпирическую психологію Ф. Брентано, в частности, процесс конституированиянепосредственных данностей– внутреннее существование предмета. Такой подход стал новым акцентированием «эмпиричности» и попыткой возобновления связи между философией и психологией посредством понятия «интенциональность», которое является теоретико-познавательным принципом.In this investigation author analyses empirical psychology of F.Brentano –the procces of constitute spontaneous facts as inside existence the object. This idea have an influence development of the transcendental phenomenology, hermeneutical phenomenology and have be essential for development of the contemporary philosophy of the value

Современные проблемы профессионального образования рабочих кадров в рамках экономического развития РФ

Рассмотрены проблемы, возникающие при подготовке и переподготовке рабочих кадров в сфере профессионального образования. Предложены меры по повышению эффективности и конкурентоспособности профессионального образования при подготовке рабочих кадров

Technique of definition of cracking resistance characteristics of metal plates and envelopes of small thickness

The technique of cracking resistance tests of metal plates of small thickness is given. Features of such tests, among which are occurrence of warp in the places of fastening of plates, occurrence of waves because of loss of stability at out-centre loading are shown. Ways to eliminate these shortcomings with the help of special equipment are specified. Tests by the proposed methods allow to make recommendations for technology and choice of steels at creation of valve tapes

REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Purpose: REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data. Methods: An international, prospective cohort study recruited cancer patients in 26 hospitals in eight countries between April 2014 and March 2017. Target recruitment was 5300 patients. Eligible patients had breast, prostate or lung cancer and planned potentially curable radiotherapy. Radiotherapy was prescribed according to local regimens, but centres used standardised data collection forms. Pre-treatment blood samples were collected. Patients were followed for a minimum of 12 (lung) or 24 (breast/prostate) months and summary descriptive statistics were generated. Results: The study recruited 2069 breast (99% of target), 1808 prostate (86%) and 561 lung (51%) cancer patients. The centralised, accessible database includes: physician-(47,025 forms) and patient-(54,901) reported outcomes; 11,563 breast photos; 17,107 DICOMs and 12,684 DVHs. Imputed genotype data are available for 4223 patients with European ancestry (1948 breast, 1728 prostate, 547 lung). Radiation-induced lymphocyte apoptosis (RILA) assay data are available for 1319 patients. DNA (n = 4409) and PAXgene tubes (n = 3039) are stored in the centralised biobank. Example prevalences of 2-year (1-year for lung) grade >= 2 CTCAE toxicities are 13% atrophy (breast), 3% rectal bleeding (prostate) and 27% dyspnoea (lung). Conclusion: The comprehensive centralised database and linked biobank is a valuable resource for the radiotherapy community for validating predictive models and biomarkers. Patient summary: Up to half of cancer patients undergo radiation therapy and irradiation of surrounding healthy tissue is unavoidable. Damage to healthy tissue can affect short-and long-term quality-of-life. Not all patients are equally sensitive to radiation "damage" but it is not possible at the moment to identify those who are. REQUITE was established with the aim of trying to understand more about how we could predict radiation sensitivity. The purpose of this paper is to provide an overview and summary of the data and material available. In the REQUITE study 4400 breast, prostate and lung cancer patients filled out questionnaires and donated blood. A large amount of data was collected in the same way. With all these data and samples a database and biobank were created that showed it is possible to collect this kind of information in a standardised way across countries. In the future, our database and linked biobank will be a resource for research and validation of clinical predictors and models of radiation sensitivity. REQUITE will also enable a better understanding of how many people suffer with radiotherapy toxicity