Polyvinyl Alcohol/Graphene Oxide Conductive Hydrogels via the Synergy of Freezing and Salting Out for Strain Sensors

Hydrogels of flexibility, strength, and conductivity have demonstrated broad applications in wearable electronics and soft robotics. However, it is still a challenge to fabricate conductive hydrogels with high strength massively and economically. Herein, a simple strategy is proposed to design a strong ionically conductive hydrogel. This ion-conducting hydrogel was obtained under the synergistic action by salting out the frozen mixture of polyvinyl alcohol (PVA) and graphene oxide (GO) using a high concentration of sodium chloride solution. The developed hydrogel containing only 5 wt% PVA manifests good tensile stress (65 kPa) and elongation (180%). Meanwhile, the PVA matrix doped with a small amount of GO formed uniformly porous ion channels after salting out, endowed the PVA/GO hydrogel with excellent ionic conductivity (up to 3.38 S m; -1; ). Therefore, the fabricated PVA/GO hydrogel, anticipated for a strain sensor, exhibits good sensitivity (Gauge factor = 2.05 at 100% strain), satisfying working stability (stably cycled for 10 min), and excellent recognition ability. This facile method to prepare conductive hydrogels displays translational potential in flexible electronics for engineering applications

Bioinspired cellulose-integrated MXene-based hydrogels for multifunctional sensing and electromagnetic interference shielding

Bioinspired hydrogels are complex materials with distinctive properties comparable to biological tissues. Their exceptional sensitivity to various external stimuli leads to substantial application potential in wearable smart devices. However, these multifaceted hydrogels are often challenging to be combined with pattern customization, stimulus responsiveness, self-healing, and biocompatibility. Herein, inspired by mussel secretions, a printable, self-healing, and biocompatible MXene-based composite hydrogel was designed and prepared by incorporating Ti3C2Tx MXene nanosheets into the hydrogel framework through the chelation of calcium ions (Ca2+) with polyacrylic acid and cellulose nanofibers at alkaline conditions. The biocompatible conductive hydrogel exhibited sensitivity (gauge factor of 2.16), self-healing (within 1 s), recognition, and adhesion, distinguishing it as an ideal candidate for wearable multifunctional sensors toward strain sensing, vocal sensing, signature detection, and Morse code transmission. Additionally, the multifunctional hydrogel manifested efficient electromagnetic interference shielding properties (reaching more than 30 dB at a thickness of 2.0 mm), protecting electronics and humans from electromagnetic radiation and pollution. Therefore, the presented work represents a versatile strategy for developing environmentally friendly conductive hydrogels, demonstrating the perspectives of intelligent hydrogels for multifunctional applications

Printed Structurally Colored Cellulose Sensors and Displays

Hydroxypropyl cellulose (HPC) is a commercially available and biodegradable cellulose derivative, which is known to self-assemble into chiral nematic liquid crystal phases in water. These features, including liquid crystal-induced selective reflections in the visible range, make HPC an ideal biopolymer host material for dynamic structural color-shifting materials. Herein, HPC is used as a starting matrix material and found that, by adding carbon nanotubes (CNT) to an aqueous dispersion of HPC, the color saturation can be improved without influencing the structural color formation and simultaneously conferring electrical conductivity to the material. Additionally, up to 0.4 wt% of cellulose nanofibrils (CNF) can be added to control and tune the rheological properties of the suspension allowing for 3D printability while also maintaining the structural colors. The HPC-CNT-CNF printed composite materials show application for flexible color-changing devices in the form of a dual readout optical and resistive strain sensor and is used as the active material in a dynamic seven-segment color display. This multipurpose color-changing material has the potential to be used in the creation of eco-friendly visual intelligent devices and biodegradable user interfaces and, as such, contributes to the advancement of the field of sustainable and green electronics.ISSN:2365-709XISSN:2365-709

Safety assessment of freeze-dried powdered Cassiae Semen: evaluation of chronic toxicity (26-week) in Sprague-Dawley rats

There is a lack of safety assessment data regarding the long-term consumption of Cassiae Semen (Leguminosae, the seeds of Cassia obtusifolia L. and Cassia tora L.). Thus, we evaluated the toxicity of freeze-dried powdered Cassiae Semen in male and female Sprague-Dawley rats. Rats were intragastrically administered freeze-dried powdered Cassiae Semen at a dose of 0.5, 2.2, or 10.0 g/kg body weight/day for 26 weeks; several variables were assessed after 13 and 26 weeks as well as after a 4-week recovery period. No mortality was observed in the treated animals, and body weight increased in a dose-dependent manner. The total bilirubin (TBIL) levels also displayed a dose-dependent relationship. In males, at 26 weeks, there were significant increases in relative kidney weights in the 2.2 and 10.0 g/kg groups compared with that in the negative control group (p < 0.05 or p < 0.01). Pigment deposition in the epithelial cells of the renal proximal convoluted tubules and atrophy or regeneration of renal tubules were observed in the 10.0 g/kg group after 26 weeks, and these changes were not fully reversed after the 4-week recovery period. Under the studied conditions, the primary toxicity organs for freeze-dried powdered Cassiae Semen in the 10.0 g/kg group were the kidneys. Keywords: Cassiae Semen, Freeze-dried powder, Chronic toxicity, Toxicity organ

Investigation of mechanical properties of PVA fiber-reinforced cementitious composites under the coupling effect of wet-thermal and chloride salt environment

In this study, the mechanical properties of polyvinyl alcohol fiber-reinforced cementitious composites (PVA-FRCC) under the coupling effect of wet thermal and chloride salt environment were investigated through a series of experiments, including compressive strength, flexural performance, elastic modulus, three-point bending fracture, and scanning electron microscope (SEM) tests. An environmental simulation test chamber was used to simulate the wet-thermal and chloride salt environment, in which the parameters of temperature, relative humidity (RH), mass fraction of the NaCl solution, and action time were determined to be 50 °C, 100%, 5%, and 30 d, respectively. The volume contents of the PVA fibers incorporated in the cementitious composites were 0, 0.3%, 0.6%, 0.9%, 1.2%, and 1.5%. The results indicated that the mechanical properties of the cementitious composites decreased after being subjected to the coupling effect of the wet-thermal and chloride salt environment. The incorporation of the PVA fibers improved the mechanical properties of the cementitious composites under the coupling effect of the wet-thermal and chloride salt environment. When the addition content of PVA fiber was approximately 0.6–0.9%, the mechanical performance of PVA-FRCC was the best. Compared with the cementitious composite without fibers, the maximum growth rates of the cube, axial and residual compressive strength, elastic modulus, and flexural strength of the PVA-FRCC under the coupling effect of the wet-thermal and chloride salt environment owing to the addition of PVA fiber reached 29.96%, 46.92%, 29.71%, 46.15%, and 67.06%, respectively. In particular, the 1.5% PVA fiber dosage increased the initiation and unstable fracture toughness, and fracture energy by 145.57%, 333.01%, and 2656.38%, respectively

Remote light-responsive nanocarriers for controlled drug delivery: advances and perspectives

Engineering of smart photoactivated nanomaterials for targeted drug delivery systems (DDS) has recently attracted considerable research interest as light enables precise and accurate controlled release of drug molecules in specific diseased cells and/or tissues in a highly spatial and temporal manner. In general, the development of appropriate light-triggered DDS relies on processes of photolysis, photoisomerization, photo-cross-linking/un-cross-linking, and photoreduction, which are normally sensitive to ultraviolet (UV) or visible (Vis) light irradiation. Considering the issues of poor tissue penetration and high phototoxicity of these high-energy photons of UV/Vis light, recently nanocarriers have been developed based on light-response to low-energy photon irradiation, in particular for the light wavelengths located in the near infrared (NIR) range. NIR light-triggered drug release systems are normally achieved by using two-photon absorption and photon upconversion processes. Herein, recent advances of light-responsive nanoplatforms for controlled drug release are reviewed, covering the mechanism of light responsive small molecules and polymers, UV and Vis light responsive nanocarriers, and NIR light responsive nanocarriers. NIR-light triggered drug delivery by two-photon excitation and upconversion luminescence strategies is also included. In addition, the challenges and future perspectives for the development of light triggered DDS are highlighted

Compression of optical pulses using a free-space angular- chirp-enhanced delay cavity

We present a study of compression of optical pulses using a free-space angular-chirp enhanced delay (FACED) cavity. The amount of induced dispersion can be adjusted by simply modifying the geometry of the FACED cavity

In vivo corneal elastography: A topical review of challenges and opportunities

Clinical measurement of corneal biomechanics can aid in the early diagnosis, progression tracking, and treatment evaluation of ocular diseases. Over the past two decades, interdisciplinary collaborations between investigators in optical engineering, analytical biomechanical modeling, and clinical research has expanded our knowledge of corneal biomechanics. These advances have led to innovations in testing methods (ex vivo, and recently, in vivo) across multiple spatial and strain scales. However, in vivo measurement of corneal biomechanics remains a long-standing challenge and is currently an active area of research. Here, we review the existing and emerging approaches for in vivo corneal biomechanics evaluation, which include corneal applanation methods, such as ocular response analyzer (ORA) and corneal visualization Scheimpflug technology (Corvis ST), Brillouin microscopy, and elastography methods, and the emerging field of optical coherence elastography (OCE). We describe the fundamental concepts, analytical methods, and current clinical status for each of these methods. Finally, we discuss open questions for the current state of in vivo biomechanics assessment techniques and requirements for wider use that will further broaden our understanding of corneal biomechanics for the detection and management of ocular diseases, and improve the safety and efficacy of future clinical practice

Identification and expression profile analysis of odorant binding protein and chemosensory protein genes in Bemisia tabaci MED by head transcriptome.

Odorant binding proteins (OBPs) and chemosensory proteins (CSPs) of arthropods are thought to be involved in chemical recognition which regulates pivotal behaviors including host choice, copulation and reproduction. In insects, OBPs and CSPs located mainly in the antenna but they have not been systematically characterized yet in Bemisia tabaci which is a cryptic species complex and could damage more than 600 plant species. In this study, among the 106,893 transcripts in the head assembly, 8 OBPs and 13 CSPs were identified in B. tabaci MED based on head transcriptomes of adults. Phylogenetic analyses were conducted to investigate the relationships of B. tabaci OBPs and CSPs with those from several other important Hemipteran species, and the motif-patterns between Hemiptera OBPs and CSPs were also compared by MEME. The expression profiles of the OBP and CSP genes in different tissues of B. tabaci MED adults were analyzed by real-time qPCR. Seven out of the 8 OBPs found in B. tabaci MED were highly expressed in the head. Conversely, only 4 CSPs were enriched in the head, while the other nine CSPs were specifically expressed in other tissues. Our findings pave the way for future research on chemical recognition of B. tabaci at the molecular level