Training and Tuning Generative Neural Radiance Fields for Attribute-Conditional 3D-Aware Face Generation

Generative Neural Radiance Fields (GNeRF) based 3D-aware GANs have demonstrated remarkable capabilities in generating high-quality images while maintaining strong 3D consistency. Notably, significant advancements have been made in the domain of face generation. However, most existing models prioritize view consistency over disentanglement, resulting in limited semantic/attribute control during generation. To address this limitation, we propose a conditional GNeRF model incorporating specific attribute labels as input to enhance the controllability and disentanglement abilities of 3D-aware generative models. Our approach builds upon a pre-trained 3D-aware face model, and we introduce a Training as Init and Optimizing for Tuning (TRIOT) method to train a conditional normalized flow module to enable the facial attribute editing, then optimize the latent vector to improve attribute-editing precision further. Our extensive experiments demonstrate that our model produces high-quality edits with superior view consistency while preserving non-target regions. Code is available at https://github.com/zhangqianhui/TT-GNeRF.Comment: 13 page

Synthesis of Alkyl Substituted Dicyclohexano-18-crown-6 Homologues for Strontium Extraction in HNO3 Media

AbstractA series of dicyclohexano-18-crown-6 (DCH18C6) homologues containing different alkyl substituents were synthesized for a comparative study of the extraction ability towards strontium. The synthesis and the structure characterization of the intermediates and the products were detailed. The crown ether homologues were labeled as CX-DCH18C6 (X=3∼7), where the X represents the number of the carbon atoms in the alkyl substituents. The extraction ability of the CX-DCH18C6 samples towards strontium in solvent extraction system was investigated. The substituent effect of the samples was discussed, and the factors affecting the separation such as solvent, acidity and initial metal concentration were examined

3D-Aware Semantic-Guided Generative Model for Human Synthesis

Generative Neural Radiance Field (GNeRF) models, which extract implicit 3D representations from 2D images, have recently been shown to produce realistic images representing rigid/semi-rigid objects, such as human faces or cars. However, they usually struggle to generate high-quality images representing non-rigid objects, such as the human body, which is of a great interest for many computer graphics applications. This paper proposes a 3D-aware Semantic-Guided Generative Model (3D-SGAN) for human image synthesis, which combines a GNeRF with a texture generator. The former learns an implicit 3D representation of the human body and outputs a set of 2D semantic segmentation masks. The latter transforms these semantic masks into a real image, adding a realistic texture to the human appearance. Without requiring additional 3D information, our model can learn 3D human representations with a photo-realistic, controllable generation. Our experiments on the DeepFashion dataset show that 3D-SGAN significantly outperforms the most recent baselines. The code is available at https://github.com/zhangqianhui/3DSGANComment: ECCV 2022. 29 page

Ceftazidime-avibactam induced renal disorders: past and present

With the increasing prevalence of multidrug-resistant Gram-negative bacterial pathogens worldwide, antimicrobial resistance has become a significant public health concern. Ceftazidime-avibactam (CAZ-AVI) exhibited excellent in vitro activity against many carbapenemase-producing pathogens, and was widely used for the treatment of various complicated infections. CAZ-AVI is well tolerated across all dosing regimens, and its associated acute kidney injury (AKI) in phase II/III clinical trials is rare. However, recent real-world studies have demonstrated that CAZ-AVI associated AKI was more frequent in real-world than in phase II and III clinical trials, particularly in patients receiving concomitant nephrotoxic agents, with critically ill patients being at a higher risk. Herein, we reviewed the safety data related to renal impairment of CAZ-AVI, and discussed its pharmacokinetic/pharmacodynamic targets and dosage adjustment in patients with impaired renal function. This review aimed to emphasize the importance for healthcare professionals to be aware of this adverse event of CAZ-AVI and provide practical insights into the dosage optimization in critically ill patients with renal dysfunction

NCOA3 Loss Disrupts Molecular Signature of Chondrocytes and Promotes Posttraumatic Osteoarthritis Progression

Background/Aims: Osteoarthritis (OA) is the most common joint disease. Recently, a novel variant near the nuclear receptor coactivator 3 (NCOA3) has been identified in association with greater risk of developing OA. However, how NCOA3 is regulated in chondrocytes and involved in OA pathogenesis remain elusive. Methods: The expression and DNA methylation of NCOA3 in knee OA cartilage and in vitro dedifferentiated chondrocytes with or without rs6094710 SNP were analyzed by qRT-PCR, immunoblotting, methylation-specific PCR and bisulfite sequencing. NCOA3 was depleted by siRNA or shRNA or inhibited by a chemical inhibitor to assess its role in chondrocyte dedifferentiation or OA pathogenesis in posttraumatic OA animal model established by cruciate ligament transection surgery. Results: We found that compared with normal counterparts, samples with rs6094710 SNP failed to upregulate NCOA3. Further evidence associated this phenotype with DNMT1-mediated hypermethylation in gene promoter region. Moreover, we showed that NCOA3 maintained the molecular signature of chondrocytes dedifferentiating in vitro or exposed to IL-1β, nevertheless, NCOA3 appeared dispensable for preventing OA initiation, since NCOA3 loss did not trigger OA in young mice. Instead, NCOA3 loss promoted posttraumatic OA progression, and in parallel, enhanced NF-κB activation. Finally, the promoted posttraumatic OA progression was significantly retarded when administrated with NF-κB pathway inhibitor, suggesting that NCOA3 lose promotes posttraumatic OA at least partially by enhancing NF-κB activation. Conclusion: Thus, our findings indicate a critical role of NCOA3 in chondrocytes, and imply that manipulating NCOA3 might present a potential therapeutic approach to interfere OA progression

SNAP23 Is Selectively Expressed in Airway Secretory Cells and Mediates Baseline and Stimulated Mucin Secretion

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23 (23-kDa paralogue of synaptosome-associated protein of 25 kDa), selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type (WT) mice at the same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated

SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion

Airway mucin secretion is important pathophysiologically and as a model of polarized epithelial regulated exocytosis. We find the trafficking protein, SNAP23 (23-kDa paralogue of synaptosome-associated protein of 25 kDa), selectively expressed in secretory cells compared with ciliated and basal cells of airway epithelium by immunohistochemistry and FACS, suggesting that SNAP23 functions in regulated but not constitutive epithelial secretion. Heterozygous SNAP23 deletant mutant mice show spontaneous accumulation of intracellular mucin, indicating a defect in baseline secretion. However mucins are released from perfused tracheas of mutant and wild-type (WT) mice at the same rate, suggesting that increased intracellular stores balance reduced release efficiency to yield a fully compensated baseline steady state. In contrast, acute stimulated release of intracellular mucin from mutant mice is impaired whether measured by a static imaging assay 5 min after exposure to the secretagogue ATP or by kinetic analysis of mucins released from perfused tracheas during the first 10 min of ATP exposure. Together, these data indicate that increased intracellular stores cannot fully compensate for the defect in release efficiency during intense stimulation. The lungs of mutant mice develop normally and clear bacteria and instilled polystyrene beads comparable to WT mice, consistent with these functions depending on baseline secretion that is fully compensated

The effect of controllable train-tail devices on the longitudinal impulse of the combined trains under initial braking

Abstract The 20,000-ton combined train running has greatly promoted China’s heavy-haul railway transportation capability. The application of controllable train-tail devices could improve the braking wave of the train and braking synchronism, and alleviate longitudinal impulse. However, the characteristics of the controllable train-tail device such as exhaust area, exhaust duration and exhaust action time are not uniform in practice, and their effects on the longitudinal impulse of the train are not apparent, which is worth studying. In this work, according to the formation of the Datong–Qinhuangdao Railway, the train air brake and longitudinal dynamics simulation system (TABLDSS) is applied to establish a 20,000-ton combined train model with the controllable train-tail device, and the braking characteristics and the longitudinal impulse of the train are calculated synchronously with changing the air exhaust time, exhaust area, and action lag time under initial braking. The results show that the maximum coupler force of the combined train will decrease with the extension of the continuous exhaust time, while the total exhaust time of the controllable train-tail device remains unchanged; the maximum coupler force of the combined train reduces by 32.5% with the exhaust area increasing from 70% to 140%; when the lag time between the controllable train-tail device and the master locomotive is more than 1.5 s, the maximum coupler force of the train increases along with the time difference enlargement

Avian Alarm Calls Do Not Induce Anti-Predator Response in Three Anuran Species

Many species produce alarm calls in response to predators, and the anti-predator signals are often used by other species. Eavesdropping on heterospecific alarm calls has been widely found in bird and mammal species. Other taxa, such as reptiles and amphibians, however, receive limited attention at present. Here, we selected three types of alarm calls of Japanese Tits (Parus minor) that were evoked by the Siberian Chipmunk (Eutamias sibiricus), Eurasian Sparrow Hawk (Accipiter nisus), and model snake (Elaphe spp.), respectively, and then carried out playback experiments to test whether three frog species changed their behaviors in response to the three treatments of Japanese Tit calls while the tit’s territory song was used as a control. The results showed that Little Torrent Frogs (Amolops torrentis), Ornamented Pygmy Frogs (Microhyla fissipes) and Spot-legged Treefrogs (Polypedates megacephalus) did not jump off their positions in response to the same four acoustic signals. They also did not change their calling behaviors in response to the alarm calls of Japanese Tits. This study found no evidence that these anuran species can eavesdrop on heterospecific tits’ alarm signals

Exploring the risk transmission characteristics among unsafe behaviors within urban railway construction accidents

Various construction accidents are proven to be caused by multiple unsafe behaviors (e.g., wrong use of PPE), but the risk transmission among different behaviors remains unclear. This paper provides insight into risk transmission through behavioral risk chain that leads to accidents from a system safety perspective. To better understand the coupling mechanism of various unsafe behaviors, integrate different behavioral risk chains and present the risk transmission process, a directed-weighted complex network (DWCN) method was adopted. Historical urban railway construction accidents in China are investigated to extract behavioral risk chain. A DW-BRCNA is applied to integrated behavioral risk chain and the behavioral risk transmission characteristics are explored and clarified by the five network properties, including degree and degree distribution, node strength and node strength distribution, average path length and diameter, weighted clustering coefficient and betweenness centrality. The results show that DW-BRCNA has the characteristics of a small-world, scale-free and hierarchical network, indicating that some unsafe behaviors are of greater importance in the process of risk transmission through behavioral risk chains. In addition, risk transmission in critical behavioral risk chains is more potentially to lead to accidents. This study proposed a new perspective of accident causation analysis from risk transmission among unsafe behaviors. It explains the risk transmission characteristics by a DWCN method based on behavioral risk chains. The findings also provide a practical guidance for developing control strategies on sites to prevent risk transmission and reduce accidents