780 research outputs found
Stabilization of Therapeutic Proteins
We present results of molecular simulations, quantum mechanical calculations, and experimental data aimed towards the rational design of solvent formulations. In particular, we have found that the rate limitation of oxidation of methionine groups is determined by the breaking of O-O bonds in hydrogen peroxide, not by the rate of acidic catalysis as previously thought. We have used this understanding to design molecular level parameters which are correlated to experimental data. Rate data has been determined both for G-CSF and for hPTH(1-34).Singapore-MIT Alliance (SMA
A Current Mode Detector Array for Gamma-Ray Asymmetry Measurements
We have built a CsI(Tl) gamma-ray detector array for the NPDGamma experiment
to search for a small parity-violating directional asymmetry in the angular
distribution of 2.2 MeV gamma-rays from the capture of polarized cold neutrons
by protons with a sensitivity of several ppb. The weak pion-nucleon coupling
constant can be determined from this asymmetry. The small size of the asymmetry
requires a high cold neutron flux, control of systematic errors at the ppb
level, and the use of current mode gamma-ray detection with vacuum photo diodes
and low-noise solid-state preamplifiers. The average detector photoelectron
yield was determined to be 1300 photoelectrons per MeV. The RMS width seen in
the measurement is therefore dominated by the fluctuations in the number of
gamma rays absorbed in the detector (counting statistics) rather than the
intrinsic detector noise. The detectors were tested for noise performance,
sensitivity to magnetic fields, pedestal stability and cosmic background. False
asymmetries due to gain changes and electronic pickup in the detector system
were measured to be consistent with zero to an accuracy of in a few
hours. We report on the design, operating criteria, and the results of
measurements performed to test the detector array.Comment: 33 pages, 20 figures, 2 table
Structure and Magnetization of Two-Dimensional Vortex Arrays in the Presence of Periodic Pinning
Ground-state properties of a two-dimensional system of superconducting
vortices in the presence of a periodic array of strong pinning centers are
studied analytically and numerically. The ground states of the vortex system at
different filling ratios are found using a simple geometric argument under the
assumption that the penetration depth is much smaller than the spacing of the
pin lattice. The results of this calculation are confirmed by numerical studies
in which simulated annealing is used to locate the ground states of the vortex
system. The zero-temperature equilibrium magnetization as a function of the
applied field is obtained by numerically calculating the energy of the ground
state for a large number of closely spaced filling ratios. The results show
interesting commensurability effects such as plateaus in the B-H diagram at
simple fractional filling ratios.Comment: 12 pages, 19 figures, submitted for publicatio
Optical transmission losses in materials due to repeated impacts of liquid droplets
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76812/1/AIAA-7018-720.pd
Inverse problems for Sturm-Liouville equations with boundary conditions linearly dependent on the spectral parameter from partial information
[[abstract]]Abstract.In this paper, we study the inverse spectral problems for Sturm–Liouville equations with boundary conditions linearly dependent on the spectral parameter and show that the potential of such problem can be uniquely determined from partial information on the potential and parts of two spectra, or alternatively, from partial information on the potential and a subset of pairs of eigenvalues and the normalization constants of the corresponding eigenvalues.[[notice]]補正完畢[[journaltype]]國外[[incitationindex]]SCI[[ispeerreviewed]]Y[[booktype]]紙本[[booktype]]電子版[[countrycodes]]DE
High contrast D line electromagnetically induced transparency in nanometric-thin rubidium vapor cell
Electromagnetically induced transparency (EIT) on atomic D line of
rubidium is studied using a nanometric-thin cell with atomic vapor column
length in the range of L= 400 - 800 nm. It is shown that the reduction of the
cell thickness by 4 orders as compared with an ordinary cm-size cell still
allows to form an EIT resonance for ( nm) with the
contrast of up to 40%. Remarkable distinctions of EIT formation in
nanometric-thin and ordinary cells are demonstrated. Despite the Dicke effect
of strong spectral narrowing and increase of the absorption for , EIT resonance is observed both in the absorption and the fluorescence
spectra for relatively low intensity of the coupling laser. Well resolved
splitting of the EIT resonance in moderate magnetic field for
can be used for magnetometry with nanometric spatial resolution. The presented
theoretical model well describes the observed results.Comment: Submitted to Applied Physics B: Lasers and Optics, 9 pages, 10
figure
Mott Transition in An Anyon Gas
We introduce and analyze a lattice model of anyons in a periodic potential
and an external magnetic field which exhibits a transition from a Mott
insulator to a quantum Hall fluid. The transition is characterized by the anyon
statistics, , which can vary between Fermions, , and Bosons,
. For bosons the transition is in the universality class of the
classical three-dimensional XY model. Near the Fermion limit, the transition is
described by a massless Dirac theory coupled to a Chern-Simons gauge
field. Analytic calculations perturbative in , and also a large
N-expansion, show that due to gauge fluctuations, the critical properties of
the transition are dependent on the anyon statistics. Comparison with previous
calcualations at and near the Boson limit, strongly suggest that our lattice
model exhibits a fixed line of critical points, with universal critical
properties which vary continuosly and monotonically as one passes from Fermions
to Bosons. Possible relevance to experiments on the transitions between
plateaus in the fractional quantum Hall effect and the magnetic field-tuned
superconductor-insulator transition are briefly discussed.Comment: text and figures in Latex, 41 pages, UBCTP-92-28, CTP\#215
Interacting new agegraphic viscous dark energy with varying
We consider the new agegraphic model of dark energy with a varying
gravitational constant, , in a non-flat universe. We obtain the equation of
state and the deceleration parameters for both interacting and noninteracting
new agegraphic dark energy. We also present the equation of motion determining
the evolution behavior of the dark energy density with a time variable
gravitational constant. Finally, we generalize our study to the case of viscous
new agegraphic dark energy in the presence of an interaction term between both
dark components.Comment: 12 pages, accepted for publication in IJTP (2010
Restoring New Agegraphic Dark Energy in RS II Braneworld
Motivated by recent works [1,2], we investigate new agegraphic model of dark
energy in the framework of RS II braneworld. We also include the case of
variable gravitational constant in our model. Furthermore, we establish
correspondence between the new agegraphic dark energy with other dark energy
candidates based on scalar fields.Comment: 13 pages, accepted for publication in IJT
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