HETEAC: The Aerosol Classification Model for EarthCARE

We introduce the Hybrid End-To-End Aerosol Classification (HETEAC) model for the upcoming EarthCARE mission. The model serves as the common baseline for development, evaluation, and implementation of EarthCARE algorithms. It shall ensure the consistency of different aerosol products from the multi-instrument platform as well as facilitate the conform specification of broad-band optical properties necessary for the EarthCARE radiative closure efforts. The hybrid approach ensures the theoretical description of aerosol microphysics consistent with the optical properties of various aerosol types known from observations. The end-to-end model permits the uniform representation of aerosol types in terms of microphysical, optical and radiative properties

Hematopoietic stem cell transplantation for adolescents and adults with inborn errors of immunity: an EBMT IEWP study.

peer reviewedAllogeneic hematopoietic stem cell transplantation (HSCT) is the gold standard curative therapy for infants and children with many inborn errors of immunity (IEI), but adolescents and adults with IEI are rarely referred for transplant. Lack of published HSCT outcome data outside small, single-center studies and perceived high risk of transplant-related mortality have delayed the adoption of HSCT for IEI patients presenting or developing significant organ damage later in life. This large retrospective, multicenter HSCT outcome study reports on 329 IEI patients (age range, 15-62.5 years at HSCT). Patients underwent first HSCT between 2000 and 2019. Primary endpoints were overall survival (OS) and event-free survival (EFS). We also evaluated the influence of IEI-subgroup and IEI-specific risk factors at HSCT, including infections, bronchiectasis, colitis, malignancy, inflammatory lung disease, splenectomy, hepatic dysfunction, and systemic immunosuppression. At a median follow-up of 44.3 months, the estimated OS at 1 and 5 years post-HSCT for all patients was 78% and 71%, and EFS was 65% and 62%, respectively, with low rates of severe acute (8%) or extensive chronic (7%) graft-versus-host disease. On univariate analysis, OS and EFS were inferior in patients with primary antibody deficiency, bronchiectasis, prior splenectomy, hepatic comorbidity, and higher hematopoietic cell transplant comorbidity index scores. On multivariable analysis, EFS was inferior in those with a higher number of IEI-associated complications. Neither age nor donor had a significant effect on OS or EFS. We have identified age-independent risk factors for adverse outcome, providing much needed evidence to identify which patients are most likely to benefit from HSCT

Solvent-free mechanochemical synthesis of π–π stacked arene–perfluoroarene co-crystals

The 1:1 π–π stacked co-crystals of naphthalene–octafluoronaphthalene and biphenyl–decafluorobiphenyl were synthesized by manual grinding of arene and perfluoroarene

Limits imposed on millimeter and sub-millimeter wave limb sounders by continuum emissions

Upprättat; 1996; 20070514 (pafi

ICAROHS - Inter-Comparison of Aerosol Retrievals and Observational Requirements for Multi-wavelength HSRL Systems

The ESA-STSE study ICAROHS exploits the potential improvements and benefits of novel multi-wavelength High Spectral Resolution Lidar (HSRL) technology combined with innovative retrieval methods for future satellite missions. Single-wavelength HSRL data from several field studies form the data base for developing improved scientific algorithms for retrievals of aerosol optical properties and of tools for future multi-wavelength spaceborne HSRL instrument assessments. These quality-controlled observational data feed into the existing EarthCARE simulator (ECSIM), which serves as the platform for algorithm development and verification. Light scattering by non-spherical particles is implemented into ECSIM as scattering libraries based on T-matrix calculations. Recommendations for future multi-wavelength HSRL missions are formulated on the basis of a combined retrieval of aerosol properties from the entire available lidar and in-situ data. This retrieval study forms the benchmark for aerosol properties accessible by respective HSRL missions and defines the technical limits for required accuracy and resolution of the lidar input data to the novel algorithms

HETEAC: The Aerosol Classification Model for EarthCARE

We introduce the Hybrid End-To-End Aerosol Classification (HETEAC) model for the upcoming EarthCARE mission. The model serves as the common baseline for development, evaluation, and implementation of EarthCARE algorithms. It shall ensure the consistency of different aerosol products from the multi-instrument platform as well as facilitate the conform specification of broad-band optical properties necessary for the EarthCARE radiative closure efforts. The hybrid approach ensures the theoretical description of aerosol microphysics consistent with the optical properties of various aerosol types known from observations. The end-to-end model permits the uniform representation of aerosol types in terms of microphysical, optical and radiative properties

HETEAC: The Aerosol Classification model for EarthCARE

We introduce the Hybrid End-To-End Aerosol Classification (HETEAC) model for the upcoming EarthCARE mission. The model serves as the common baseline for development, evaluation, and implementation of EarthCARE algorithms. It shall ensure the consistency of different aerosol products from the multi-instrument platform as well as facilitate the conform specification of broad-band optical properties necessary for the EarthCARE radiative closure efforts. The hybrid approach ensures the theoretical description of aerosol microphysics consistent with the optical properties of various aerosol types known from observations. The end-to-end model permits the uniform representation of aerosol types in terms of microphysical, optical and radiative properties

HETEAC: The Aerosol Classification Model for EarthCARE

We introduce the Hybrid End-To-End Aerosol Classification (HETEAC) model for the upcoming EarthCARE mission. The model serves as the common baseline for development, evaluation, and implementation of EarthCARE algorithms. It shall ensure the consistency of different aerosol products from the multi-instrument platform as well as facilitate the conform specification of broad-band optical properties necessary for the EarthCARE radiative closure efforts. The hybrid approach ensures the theoretical description of aerosol microphysics consistent with the optical properties of various aerosol types known from observations. The end-to-end model permits the uniform representation of aerosol types in terms of microphysical, optical and radiative properties