1,264 research outputs found
Are Asians comfortable with discussing death in health valuation studies? A study in multi-ethnic Singapore
BACKGROUND
To characterize ease in discussing death (EID) and its influence on health valuation in a multi-ethnic Asian population and to determine the acceptability of various descriptors of death and "pits"/"all-worst" in health valuation.
METHODS
In-depth interviews (English or mother-tongue) among adult Chinese, Malay and Indian Singaporeans selected to represent both genders and a wide range of ages/educational levels. Subjects rated using 0–10 visual analogue scales (VAS): (1) EID, (2) acceptability of 8 descriptors for death, and (3) appropriateness of "pits" and "all-worst" as descriptors for the worst possible health state. Subjects also valued 3 health states using VAS followed by time trade-off (TTO). The influence of sociocultural variables on EID and these descriptors was studied using univariable analyses and multiple linear regression (MLR). The influence of EID on VAS/TTO utilities with adjustment for sociocultural variables was assessed using MLR.
RESULTS
Subjects (n = 63, 35% Chinese, 32% Malay, median age 44 years) were generally comfortable with discussing death (median EID: 8.0). Only education significantly influenced EID (p = 0.045). EID correlated weakly with VAS/TTO scores (range: VAS: -0.23 to 0.07; TTO: -0.14 to 0.11). All subjects felt "passed away", "departed" and "deceased" were most acceptable (median acceptability: 8.0) while "sudden death" and "immediate death" were least acceptable (median acceptability: 5.0). Subjects clearly preferred "all-worst" to "pits" (63% vs. 19%, p < 0.001).
CONCLUSION
Singaporeans were generally comfortable with discussing death and had clear preferences for several descriptors of death and for "all-worst". EID is unlikely to influence health preference measurement in health valuation studies
One-dimensional collision carts computer model and its design ideas for productive experiential learning
We develop an Easy Java Simulation (EJS) model for students to experience the
physics of idealized one-dimensional collision carts. The physics model is
described and simulated by both continuous dynamics and discrete transition
during collision. In the field of designing computer simulations, we discuss
briefly three pedagogical considerations such as 1) consistent simulation world
view with pen paper representation, 2) data table, scientific graphs and
symbolic mathematical representations for ease of data collection and multiple
representational visualizations and 3) game for simple concept testing that can
further support learning. We also suggest using physical world setup to be
augmented complimentary with simulation while highlighting three advantages of
real collision carts equipment like tacit 3D experience, random errors in
measurement and conceptual significance of conservation of momentum applied to
just before and after collision. General feedback from the students has been
relatively positive, and we hope teachers will find the simulation useful in
their own classes. 2015 Resources added:
http://iwant2study.org/ospsg/index.php/interactive-resources/physics/02-newtonian-mechanics/02-dynamics/46-one-dimension-collision-js-model
http://iwant2study.org/ospsg/index.php/interactive-resources/physics/02-newtonian-mechanics/02-dynamics/195-elastic-collisionComment: 6 pages, 8 figures, 1 table, 1 L. K. Wee, Physics Education 47 (3),
301 (2012); ISSN 0031-912
Two-State Spectral-Free Solutions of Frenkel-Moore Simplex Equation
Whilst many solutions have been found for the Quantum Yang-Baxter Equation
(QYBE), there are fewer known solutions available for its higher dimensional
generalizations: Zamolodchikov's tetrahedron equation (ZTE) and Frenkel and
Moore's simplex equation (FME). In this paper, we present families of solutions
to FME which may help us to understand more about higher dimensional
generalization of QYBE.Comment: LaTeX file. Require macros: cite.sty and subeqnarray.sty to process.
To appear in J. Phys. A: Math. and Ge
Are symbols useful and culturally acceptable in health-state valuation studies? An exploratory study in a multi-ethnic Asian population
10.2147/PPA.S4142Patient Preference and Adherence2271-27
Cationic vacancy induced room-temperature ferromagnetism in transparent conducting anatase Ti_{1-x}Ta_xO_2 (x~0.05) thin films
We report room-temperature ferromagnetism in highly conducting transparent
anatase Ti1-xTaxO2 (x~0.05) thin films grown by pulsed laser deposition on
LaAlO3 substrates. Rutherford backscattering spectrometry (RBS), x-ray
diffraction (XRD), proton induced x-ray emission (PIXE), x-ray absorption
spectroscopy (XAS) and time-of-flight secondary ion mass spectrometry
(TOF-SIMS) indicated negligible magnetic contaminants in the films. The
presence of ferromagnetism with concomitant large carrier densities was
determined by a combination of superconducting quantum interference device
(SQUID) magnetometry, electrical transport measurements, soft x-ray magnetic
circular dichroism (SXMCD), XAS, and optical magnetic circular dichroism (OMCD)
and was supported by first-principle calculations. SXMCD and XAS measurements
revealed a 90% contribution to ferromagnetism from the Ti ions and a 10%
contribution from the O ions. RBS/channelling measurements show complete Ta
substitution in the Ti sites though carrier activation was only 50% at 5% Ta
concentration implying compensation by cationic defects. The role of Ti vacancy
and Ti3+ was studied via XAS and x-ray photoemission spectroscopy (XPS)
respectively. It was found that in films with strong ferromagnetism, the Ti
vacancy signal was strong while Ti3+ signal was absent. We propose (in the
absence of any obvious exchange mechanisms) that the localised magnetic
moments, Ti vacancy sites, are ferromagnetically ordered by itinerant carriers.
Cationic-defect-induced magnetism is an alternative route to ferromagnetism in
wide-band-gap semiconducting oxides without any magnetic elements.Comment: 21 pages, 10 figures, to appear in Philosophical Transaction - Royal
Soc.
Photoluminescent diamond nanoparticles for cell labeling: study of the uptake mechanism in mammalian cells
Diamond nanoparticles (nanodiamonds) have been recently proposed as new
labels for cellular imaging. For small nanodiamonds (size <40 nm) resonant
laser scattering and Raman scattering cross-sections are too small to allow
single nanoparticle observation. Nanodiamonds can however be rendered
photoluminescent with a perfect photostability at room temperature. Such a
remarkable property allows easier single-particle tracking over long
time-scales. In this work we use photoluminescent nanodiamonds of size <50 nm
for intracellular labeling and investigate the mechanism of their uptake by
living cells . By blocking selectively different uptake processes we show that
nanodiamonds enter cells mainly by endocytosis and converging data indicate
that it is clathrin mediated. We also examine nanodiamonds intracellular
localization in endocytic vesicles using immunofluorescence and transmission
electron microscopy. We find a high degree of colocalization between vesicles
and the biggest nanoparticles or aggregates, while the smallest particles
appear free in the cytosol. Our results pave the way for the use of
photoluminescent nanodiamonds in targeted intracellular labeling or biomolecule
deliver
Flat histogram simulation of lattice polymer systems
We demonstrate the use of a new algorithm called the Flat Histogram sampling
algorithm for the simulation of lattice polymer systems. Thermodynamics
properties, such as average energy or entropy and other physical quantities
such as end-to-end distance or radius of gyration can be easily calculated
using this method. Ground-state energy can also be determined. We also explore
the accuracy and limitations of this method.
Key words: Monte Carlo algorithms, flat histogram sampling, HP model, lattice
polymer systemsComment: 7 RevTeX two-column page
Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins
Legionella pneumophila is a ubiquitous inhabitant of environmental water reservoirs. The bacteria infect a wide variety of protozoa and, after accidental inhalation, human alveolar macrophages, which can lead to severe pneumonia. The capability to thrive in phagocytic hosts is dependent on the Dot/Icm type IV secretion system (T4SS), which translocates multiple effector proteins into the host cell. In this study, we determined the draft genome sequence of L. pneumophila strain 130b (Wadsworth). We found that the 130b genome encodes a unique set of T4SSs, namely, the Dot/Icm T4SS, a Trb-1-like T4SS, and two Lvh T4SS gene clusters. Sequence analysis substantiated that a core set of 107 Dot/Icm T4SS effectors was conserved among the sequenced L. pneumophila strains Philadelphia-1, Lens, Paris, Corby, Alcoy, and 130b. We also identified new effector candidates and validated the translocation of 10 novel Dot/Icm T4SS effectors that are not present in L. pneumophila strain Philadelphia-1. We examined the prevalence of the new effector genes among 87 environmental and clinical L. pneumophila isolates. Five of the new effectors were identified in 34 to 62% of the isolates, while less than 15% of the strains tested positive for the other five genes. Collectively, our data show that the core set of conserved Dot/Icm T4SS effector proteins is supplemented by a variable repertoire of accessory effectors that may partly account for differences in the virulences and prevalences of particular L. pneumophila strains. Copyright © 2010, American Society for Microbiology. All Rights Reserved
[Introduction] The making and unmaking of precarious, ideal subjects – migration brokerage in the Global South
The migration literature is often underpinned by the idea that migrants are either completely ‘free’ agents, individually choosing how best to achieve returns on their human capital and resources (Sjaastad 1962) or ‘agents of development’ for their home countries and regions (Turner and Kleist 2013). Conversely they are viewed as exploited slaves, being pushed into low-paid occupations and controlled by middlemen and employers. Unsurprisingly, in many close-knit societies a process as expensive and life-defining as migration is rarely undertaken as an individual act and is shaped by complex social interactions within kinship networks and beyond (Lindquist 2012). Brokerage is ever-present in migrant labour markets around the world, variously interpreted as occupying the ‘middle space’ between migrants and the state, helping migrants navigate complex immigration regimes (Lindquist, Xiang, and Yeoh 2012; McKeown 2012; Schapendonk 2017), acting as an extension of the state seeking to outsource border controls (Goh, Wee, and Yeoh 2017) and colluding with employers to cheapen and commoditise migrant labour (Guérin 2013; McCollum and Findlay 2018). It is increasingly recognised that an understanding of contemporary migration is not complete without an understanding of the mediating practices that facilitate and constrain it (Coe and Jordhus-Lier 2011; Cranston, Schapendonk, and Spaan 2018).
This special issue investigates the role that migration brokers play in the subjectivation and precarisation of migrant men and women from marginalised classes and ethnicities in the Global South. It shows how these processes are critical for them to become a part of contemporary economic and political systems of international and internal labour circulation. It responds to the call of labour geographers for a deeper understanding of the ways in which diverse economic and social contexts result in complex forms of precarity (McDowell 2015) and adds to the evidence on the role of actors beyond the workplace in co-creating precarity (Buckley, McPhee, and Rogaly 2017)
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