Anti-Poverty Strategies for the UK: Poverty and Crime Review

This review of the literature about how and why poverty and crime influence one another, and the benefits to crime reduction of reducing poverty, looks at the implications for practical policies and strategies

Regularity in the local CR embedding problem

We consider a formally integrable, strictly pseudoconvex CR manifold $M$ of hypersurface type, of dimension $2n-1\geq7$. Local CR, i.e. holomorphic, embeddings of $M$ are known to exist from the works of Kuranishi and Akahori. We address the problem of regularity of the embedding in standard H\"older spaces $C^{a}(M)$, $a\in\mathbf{R}$. If the structure of $M$ is of class $C^{m}$, $m\in\mathbf{Z}$, $4\leq m\leq\infty$, we construct a local CR embedding near each point of $M$. This embedding is of class $C^{a}$, for every $a$, $0\leq a < m+(1/2)$. Our method is based on Henkin's local homotopy formula for the embedded case, some very precise estimates for the solution operators in it, and a substantial modification of a previous Nash-Moser argument due to the second author

Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of changes in transcript levels with oocyte protein expression

Objective To investigate functionally important transcripts in single human oocytes with the use of NanoString technology and determine whether observed differences are biologically meaningful. Design Analysis of human oocytes with the use of NanoString and immunoblotting. Setting University-affiliated reproductive medicine unit. Patients Women undergoing in vitro fertilization. Intervention Human oocytes were analyzed with the use of NanoString or immunoblotting. Main Outcome Measures The abundance of transcripts for ten functionally important genes—AURKA, AURKC, BUB1, BUB1B (encoding BubR1), CDK1, CHEK1, FYN, MOS, MAP2K1, and WEE2—and six functionally dispensable genes were analyzed with the use of NanoString. BubR1 protein levels in oocytes from younger and older women were compared with the use of immunoblotting. Result(s) All ten functional genes but none of the six dispensable genes were detectable with the use of NanoString in single oocytes. There was 3- to 5-fold variation in BUB1, BUB1B, and CDK1 transcript abundance among individual oocytes from a single patient. Transcripts for these three genes—all players within the spindle assembly checkpoint surveillance mechanism for preventing aneuploidy—were reduced in the same oocyte from an older patient. Mean BUB1B transcripts were reduced by 1.5-fold with aging and associated with marked reductions in BubR1 protein levels. Conclusion(s) The abundance of functionally important transcripts exhibit marked oocyte-to-oocyte heterogeneity to a degree that is sufficient to affect protein expression. Observed variations in transcript abundance are therefore likely to be biologically meaningful, especially if multiple genes within the same pathway are simultaneously affected

Application of the Contouring Method to Extended Microlensed Sources

The method devised by Lewis et al. (1993) for calculating the light curve of a microlensed point source is expanded to two dimensions to enable the calculation of light curves of extended sources. This method is significantly faster than the ray shooting method that has been used in the past. The increased efficiency is used to obtain much higher resolution light curves over increased timescales. We investigate the signatures arising from different source geometries in a realistic microlensing model. We show that a large fraction of high magnification events (HMEs) in image A of Q2237+0305 involve only one caustic, and could therefore yield information on the structure of the quasar continuum through the recognition of a characteristic event shape. In addition, the cataloguing of HMEs into morphological type will, in theory, enable the direction of the transverse motion, as well as the source size to be obtained from long term monitoring.Comment: 10 pages including 4 figures. Accepted for publication in M.N.R.A.

Describing results of 4000 hours of multi environment model verification test Final report

Investigating categorization and formulation of stress and strength factors for semiconductor diodes to provide improved failure rate prediction from mathematical model