Monitoring and analysis of data from complex systems

Some of the methods, systems, and prototypes that have been tested for monitoring and analyzing the data from several spacecraft and vehicles at the Marshall Space Flight Center are introduced. For the Huntsville Operations Support Center (HOSC) infrastructure, the Marshall Integrated Support System (MISS) provides a migration path to the state-of-the-art workstation environment. Its modular design makes it possible to implement the system in stages on multiple platforms without the need for all components to be in place at once. The MISS provides a flexible, user-friendly environment for monitoring and controlling orbital payloads. In addition, new capabilities and technology may be incorporated into MISS with greater ease. The use of information systems technology in advanced prototype phases, as adjuncts to mainline activities, is used to evaluate new computational techniques for monitoring and analysis of complex systems. Much of the software described (specially, HSTORESIS (Hubble Space Telescope Operational Readiness Expert Safemode Investigation System), DRS (Device Reasoning Shell), DART (Design Alternatives Rational Tool), elements of the DRA (Document Retrieval Assistant), and software for the PPS (Peripheral Processing System) and the HSPP (High-Speed Peripheral Processor)) is available with supporting documentation, and may be applicable to other system monitoring and analysis applications

Transitioning from nanomedicine to picomedicine

Inspired from biological systems, nanotechnology (and more recently, picotechnology) is beginning to revolutionize medicine including the improved prevention, diagnosis, and treatment of numerous diseases. This discussion will summarize efforts over the past decade that ave synthesized novel nanoparticles, nanotubes, and other nanomaterials to improve medicine. Efforts focused on the use of nanomaterials to minimize immune cell interactions, inhibit infection, and increase tissue growth will be especially emphasized. Tissue systems covered will include the nervous system, orthopedics, bladder, cardiovascular, vascular, and the bladder. Materials to be covered will include ceramics, metals, polymers, and composites thereof. Self-assembled nanochemistries will also be emphasized. Lastly, efforts to examine nanoparticle toxicity as well as nanosensors for the real-time monitoring of biological responses in the body will be presented. Thus, this discussion will: • summarize recent advances in novel nanomaterials for medical devices; • emphasize novel properties of nano- and pico-technology derived materials for biosensor applications; and • identify how such materials can be used to decrease inflammation, infection and improve tissue growth

Quasar-galaxy associations

There is controversy about the measurement of statistical associations between bright quasars and faint, presumably foreground galaxies. We look at the distribution of galaxies around an unbiased sample of 63 bright, moderate redshift quasars using a new statistic based on the separation of the quasar and its nearest neighbour galaxy. We find a significant excess of close neighbours at separations less than about 10 arcsec which we attribute to the magnification by gravitational lensing of quasars which would otherwise be too faint to be included in our sample. About one quarter to one third of the quasars are so affected although the allowed error in this fraction is large.Comment: uuencoded Postscript file (including figures and tables), SUSSEX-AST 94/8-

The hypocretin/orexin antagonist almorexant promotes sleep without impairment of performance in rats.

The hypocretin receptor (HcrtR) antagonist almorexant (ALM) has potent hypnotic actions but little is known about neurocognitive performance in the presence of ALM. HcrtR antagonists are hypothesized to induce sleep by disfacilitation of wake-promoting systems whereas GABAA receptor modulators such as zolpidem (ZOL) induce sleep through general inhibition of neural activity. To test the hypothesis that less functional impairment results from HcrtR antagonist-induced sleep, we evaluated the performance of rats in the Morris Water Maze in the presence of ALM vs. ZOL. Performance in spatial reference memory (SRM) and spatial working memory (SWM) tasks were assessed during the dark period after equipotent sleep-promoting doses (100 mg/kg, po) following undisturbed and sleep deprivation (SD) conditions. ALM-treated rats were indistinguishable from vehicle (VEH)-treated rats for all SRM performance measures (distance traveled, latency to enter, time within, and number of entries into, the target quadrant) after both the undisturbed and 6 h SD conditions. In contrast, rats administered ZOL showed impairments in all parameters measured compared to VEH or ALM in the undisturbed conditions. Following SD, ZOL-treated rats also showed impairments in all measures. ALM-treated rats were similar to VEH-treated rats for all SWM measures (velocity, time to locate the platform and success rate at finding the platform within 60 s) after both the undisturbed and SD conditions. In contrast, ZOL-treated rats showed impairments in velocity and in the time to locate the platform. Importantly, ZOL rats only completed the task 23-50% of the time while ALM and VEH rats completed the task 79-100% of the time. Thus, following equipotent sleep-promoting doses, ZOL impaired rats in both memory tasks while ALM rats performed at levels comparable to VEH rats. These results are consistent with the hypothesis that less impairment results from HcrtR antagonism than from GABAA-induced inhibition