965 research outputs found
Bronchialkarzinom-Screening mittels Niedrigdosis-CT:eine Perspektive für die Zukunft? Prävalenz- und Inzidenzergebnisse einer Machbarkeitsstudie an 817 asymptomatischen starken Rauchern
Da Symptome gerade in den prognostisch günstigeren Frühstadien des BC fehlen, erscheint die Untersuchung asymptomatischer Risikopatienten (Raucher) sinnvoll. Die Niedrigdosis-CT verbindet eine hohe Sensitivität mit einer geringen Strahlenbelastung. In der Münsteraner Studie wurden 817 Probanden über 7 Jahre mittels Niedrigdosis-CT untersucht. Dabei wurden BC-prävalenz und -inzidenz, Tumorstadien, -größe und -histologie, Resektionsraten sowie der Anteil an unnötigen invasiven diagnostischen Eingriffen und Intervallkarzinomen ermittelt. 96 Prozent der diagnostizierten Lungenrundherde waren benigne, BC-prävalenz und-inzidenz betrugen 1,3 und 0,86 Prozent. Stadienverteilung und Resektionsraten konnten deutlich verbessert werden, der Anteil an Intervallkarzinomen und unnötigen Eingriffen war niedrig. Grenzen bestanden in der Diagnostik von endobronchialen und hilären Tumoren. Über eine Senkung der BC- Mortalität kann mit dem einarmigen Studiendesign keine Aussage getroffen werden
1 H Chemical Shift Imaging Methodenevaluation und Anwendung in vivo: Untersuchung der Hirnasymmetrie
Superconductivity and hybrid soft modes in TiSe
The competition between superconductivity and other ground states of solids
is one of the challenging topics in condensed matter physics. Apart from
high-temperature superconductors [1,2] this interplay also plays a central role
in the layered transition-metal dichalcogenides, where superconductivity is
stabilized by suppressing charge-density-wave order to zero temperature by
intercalation [3] or applied pressure [4-7]. 1T-TiSe forms a prime example,
featuring superconducting domes on intercalation as well as under applied
pressure. Here, we present high energy-resolution inelastic x-ray scattering
measurements of the CDW soft phonon mode in intercalated CuTiSe and
pressurized 1T-TiSe along with detailed ab-initio calculations for the
lattice dynamical properties and phonon-mediated superconductivity. We find
that the intercalation-induced superconductivity can be explained by a solely
phonon-mediated pairing mechanism, while this is not possible for the
superconducting phase under pressure. We argue that a hybridization of phonon
and exciton modes in the pairing mechanism is necessary to explain the full
observed temperature-pressure-intercalation phase diagram. These results
indicate that 1T-TiSe under pressure is close to the elusive state of the
excitonic insulator
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Evaluation of segmented gamma scanner measurements on cans of recoverable scrap
Savannah River Site (SRS) has had a long-standing concern about the inability to measure recoverable scrap. A segmented gamma scanner (SGS) was evaluated for use in measuring cans of scrap materials. Four scrap cans were selected and re-packaged into containers that could be measured using calorimetry and gamma spectrometry. These scrap cans were later used as working standards for the SGS. In addition, replicate measurements were made on all cans of scrap currently stored with estimated values. Before accepting the SGS measurements on the cans, data from the replicate measurements of the standards and a limited number of process cans were analyzed to determine if there was a significant bias between the SGS and the calorimeter-gamma spectrometer measurements, if the random replication error would be acceptable for accountability, to set control limits for the workings standards, and to determine acceptable differences between replicate measurements. After completing the measurement of all process scrap cans in the inventory, the the final data were analyzed and estimates based on the two sets of data compared. The methodology used to determine the appropriate measurement error model, to estimate the measurement errors, to set control limits, and to determine the significance of the bias will be described as well as a comparison of the error estimates based on the preliminary versus final data
Hard-core Yukawa model for two-dimensional charge stabilized colloids
The hyper-netted chain (HNC) and Percus-Yevick (PY) approximations are used
to study the phase diagram of a simple hard-core Yukawa model of
charge-stabilized colloidal particles in a two-dimensional system. We calculate
the static structure factor and the pair distribution function over a wide
range of parameters. Using the statics correlation functions we present an
estimate for the liquid-solid phase diagram for the wide range of the
parameters.Comment: 7 pages, 9figure
Bezlotoxumab: A Novel Agent for the Prevention of Recurrent Clostridium difficile Infection
During the past decade, the incidence and severity of Clostridium difficile infection (CDI) have significantly increased, leading to a rise in CDI-associated hospitalizations, health care costs, and mortality. Although treatment options exist for CDI, recurrence is frequent following treatment. Furthermore, patients with at least one CDI recurrence are at an increased risk of developing additional recurrences. A novel approach to the prevention of recurrent CDI is the use of monoclonal antibodies directed against the toxins responsible for CDI as an adjunct to antibiotic treatment. Bezlotoxumab, a human monoclonal antibody that binds and neutralizes C. difficile toxin B, is the first therapeutic agent to receive United States Food and Drug Administration approval for the prevention of CDI recurrence. Clinical studies have demonstrated superior efficacy of bezlotoxumab in adults receiving antibiotic therapy for CDI compared with antibiotic therapy alone for the prevention of CDI recurrence. Bezlotoxumab was well tolerated in clinical trials, with the most common adverse effects being nausea, vomiting, fatigue, pyrexia, headache, and diarrhea. The demonstrated efficacy, safety, and characteristics of bezlotoxumab present an advance in prevention of CDI recurrence
Comparing non-safety with safety device sharps injury incidence data from two different occupational surveillance systems
The United States Occupational Safety and Health Administration (OSHA) Bloodborne Pathogens Standard as amended by the Needlestick Safety and Prevention Act requiring the use of safety-engineered medical devices to prevent needlesticks and sharps injuries has been in place since 2001. Injury changes over time include differences between those from non-safety compared with safety-engineered medical devices. This research compares two US occupational incident surveillance systems to determine whether these data can be generalized to other facilities and other countries either with legislation in place or considering developing national policies for the prevention of sharps injuries among healthcare personnel
Order and nFl Behavior in UCu4Pd
We have studied the role of disorder in the non-Fermi liquid system UCu4Pd
using annealing as a control parameter. Measurement of the lattice parameter
indicates that this procedure increases the crystallographic order by
rearranging the Pd atoms from the 16e to the 4c sites. We find that the low
temperature properties depend strongly on annealing. Whereas the non-Fermi
liquid behavior in the specific heat can be observed over a larger temperature
range after annealing, the clear non-Fermi liquid behavior of the resistivity
of the unannealed sample below 10 K disappears. We come to the conclusion that
this argues against the Kondo disorder model as an explanation for the
non-Fermi liquid properties of both as-prepared and annealed UCu4Pd
Very High Resolution Solar X-ray Imaging Using Diffractive Optics
This paper describes the development of X-ray diffractive optics for imaging
solar flares with better than 0.1 arcsec angular resolution. X-ray images with
this resolution of the \geq10 MK plasma in solar active regions and solar
flares would allow the cross-sectional area of magnetic loops to be resolved
and the coronal flare energy release region itself to be probed. The objective
of this work is to obtain X-ray images in the iron-line complex at 6.7 keV
observed during solar flares with an angular resolution as fine as 0.1 arcsec -
over an order of magnitude finer than is now possible. This line emission is
from highly ionized iron atoms, primarily Fe xxv, in the hottest flare plasma
at temperatures in excess of \approx10 MK. It provides information on the flare
morphology, the iron abundance, and the distribution of the hot plasma.
Studying how this plasma is heated to such high temperatures in such short
times during solar flares is of critical importance in understanding these
powerful transient events, one of the major objectives of solar physics. We
describe the design, fabrication, and testing of phase zone plate X-ray lenses
with focal lengths of \approx100 m at these energies that would be capable of
achieving these objectives. We show how such lenses could be included on a
two-spacecraft formation-flying mission with the lenses on the spacecraft
closest to the Sun and an X-ray imaging array on the second spacecraft in the
focal plane \approx100 m away. High resolution X-ray images could be obtained
when the two spacecraft are aligned with the region of interest on the Sun.
Requirements and constraints for the control of the two spacecraft are
discussed together with the overall feasibility of such a formation-flying
mission
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