Rapid assessment of surface-water flood-management options in urban catchments

This is the final version of the article. Available from the publisher via the DOI in this record.Surface-water flooding in urban areas has become a pressing issue due to changing precipitation patterns, expanding urban areas and ageing drainage infrastructure. Selection of flood-management options for widespread implementation using quantitative performance measures is both technically and computationally demanding, which limits the evidence available for decision support. This study presents a new framework for surface-water flood-intervention assessment at high resolution. The framework improves computational efficiency through utilisation of accessible data, simplified representations of interventions and a resource efficient cellular automata flood model. The advantages of this framework are demonstrated through an example case study where the performance of 12 high-level intervention strategies has been evaluated. Results from the case study demonstrate that the framework is able to provide quantitative performance values for a range of interventions. The speed of analysis supports the application of the framework as a decision-making tool for urban water planning.This research was supported by three UK research council funded programmes: the EPSRC Centre for Doctoral Training in Water Informatics Science and Engineering [grant number EP/L016214/1], the EPSRC research fellowship Safe & SuRe water management [grant number EP/K006924/1], and the NERC project SINATRA - Susceptibility of catchments to INTense RAinfall and flooding [grant number NE/K008765/1]. LiDAR was provided by the Environment Agency and mapping was provided through OS Mastermap data on the Digimap service

Global perspectives on groundwater infiltration to sewer networks: A threat to urban sustainability

This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: Data will be made available on request.While existing studies on sewer networks have explored topics such as surface water inflow, limited research has delved into groundwater infiltration (GWI). This study aims to fill this void by providing a comprehensive overview of quantitative analyses of GWI in sewer networks plus current status, limitations and future perspectives, considering the most relevant peer-reviewed research, including 83 studies. We propose dividing the existing research into two main groups: (1) phreatic zone, and (2) vadose zone. Most research has focused on the latter, mainly considering Rainfall-Derived Inflow and Infiltration (RDII), including surface water inflow and GWI. The ratio of each is not frequently separated; otherwise, there may be some assumptions, e.g. in dry weather and assuming zero surface water inflow. We also divided the employed approaches in different categories from physically-based numerical models, to simpler ones, e.g. water budget analysis. In fact, a combination of approaches may be applied to find the intricate characteristics of 'urban groundwater' or 'urban karst.' The findings revealed a heightened vulnerability of sewer networks to GWI, due to climate change (CC) and its associated repercussions, e.g. sea level rise (SLR), making the coastal cities the most vulnerable regions. In future research, the criticality of pre-emptive measures and monitoring of networks, especially near the coastline, is emphasised to ensure the resilience and adaptability of sewer networks in the context of GWI amid the potential impacts of CC. However, current monitoring practices lack widespread evidence for spatiotemporal analysis of GWI quantity.South West Wate

An integrated hydrological-hydrogeological model for analysing spatio-temporal probability of groundwater infiltration in urban infrastructure

This is the final version. Available from Elsevier via the DOI in this record. Data availability: Data will be made available on request.While groundwater serves as a valuable resource, its infiltration poses significant challenges to urban infrastructure. This study develops and demonstrates a computationally efficient spatio-temporal analysis of groundwater infiltration (GWI) in urban facilities, specifically sewer networks (SNs), within the Lower River Otter Water Body, United Kingdom. To achieve this, the Fuzzy-Analytic Hierarchy Process (F-AHP) within a Geographic Information System (GIS) framework was employed, considering geology, geomorphology, hydrology, hydrogeology, climate, and topography. The proposed model encompasses 16 thematic maps, categorised into 6 groups: (1) groundwater (groundwater depth (GWD)); (2) altitude (elevation, slope, and topographic wetness index); (3) precipitation (monthly precipitation); (4) ground cover (rock permeability, alluvial permeability, soil type, land cover, and made ground); (5) earth movement (fault proximity, fault length density, and mass movement); and (6) runoff (river, flood potential, and drainage density). Expert judgment, F-analysis, and AHP were applied to the layers for classification, normalisation, and weight assignment, respectively. Verified by data from outfalls, GWI probability maps were generated considering the shallowest GWD and highest precipitation for temporal analysis. Overall, higher GWI probability scores were found in regions with shallower GWD, lower elevations, especially near river, and higher permeabilities. Assigning a probability score between 0 and 1 for each 1-metre area in each season, the vulnerability maps can guide water agencies in implementing protective strategies for infrastructure. The findings contribute to enhancing groundwater sustainability in urban areas, particularly in the face of potential climate change.South West Wate

From site-focused intervention towards landscape-scale surface water management using Synthetic Stream Networks and Rapid Scenario Screening

This is the final version. Available on open access from IWA Publishing via the DOI in this recordData availability statement: All relevant data are included in the paper or its Supplementary InformationThis research addresses the need to transform success in technical understanding and practical implementation of surface water management (SWM) interventions at a site-scale towards integrated landscape-scale management. We achieve this through targeting the informative preliminary stages of strategic design, where broad, early and effective exploration of opportunities can enhance and direct a regional SWM perspective. We present a new method, ‘Synthetic Stream Networks’ (SSN), capable of meeting these requirements by taking advantage of easily accessible data, likely to be available during regional screening. We find that results from the SSN are validated by existing, ‘downstream’ focused data (90% of the river network is within 30 m of an associated SSN flow path), with the added advantage of extending understanding of surface water exceedance flow paths and watersheds into the upper catchment, thus establishing a foundational and physically based sub-catchment management unit exploring surface water connectivity at a catchment and landscape scale. We also demonstrate collaborative advantages of twinning the new SSN method with ‘Rapid Scenario Screening’ (RSS) to develop a novel approach for identifying, exploring and evaluating SWM interventions. Overall, we find that this approach addresses challenges of integrating understanding from sub-catchment, catchment and landscape perspectives within surface water management.Engineering and Physical Sciences Research Council (EPSRC)Natural Environment Research Council (NERC

Targeting property flood resilience in flood risk management

This is the final version. Available on open access from Wiley via the DOI in this recordData availability statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.In this article, we evaluate property flood resilience (PFR) to manage pluvial and combined tidal/ fluvial flood risks. We achieve this by evaluating flood risk and intervention targeting strategies across a case study in Bristol (UK) using data types generally available for preliminary option assessment. We investigate opportunities for mitigating flood damages within catchments using PFR and evaluate two targeting strategies: Installing PFR across strategic areas of a catchment and targeting interventions at specific high‐risk properties. We find that individually targeting PFR is more effective than focusing resources on specific high‐risk areas. Targeting pluvial flood measures at individual properties across our case study provides an average annual benefit per property of approximately £750 more than applying zonal targeting, supporting use of high‐resolution modelling in surface water management, and highlighting the applicability of PFR to manage damages at specific high‐risk properties which may not fall under the protection of community level defences. A similar approach provides the best outcomes for fluvial targeting; however, the hazard is more concentrated and so a zonal targeting approach may be more acceptable. Overall, we find resistance based PFR an effective intervention to mitigate damages, however complementary strategies are required when managing extreme flooding.European CommissionEngineering and Physical Sciences Research Council (EPSRC)Natural Environment Research Council (NERC

Towards Regional Scale Stormwater Flood Management Strategies through Rapid Preliminary Intervention Screening

This is the final version. Available on open access from MDPI via the DOI in this recordData Availability Statement: Data underpinning this study is available upon reasonable request through contacting the authors.his paper presents the advantages and opportunities for rapid preliminary intervention screening to enhance inclusion of green infrastructures in regional scale stormwater management. Stormwater flooding is widely recognised as a significant and worsening natural hazard across the globe; however, current management approaches aimed at the site scale do not adequately explore opportunities for integrated management at the regional scale at which decisions are made. This research addresses this gap through supporting the development of stormwater management strategies, including green infrastructure, at a regional scale. This is achieved through upscaling a modelling approach using a spatially explicit inundation model (CADDIES) coupled with an economic model of inundation loss (OpenProFIA) to support widescale evaluation of green infrastructure during the informative early-stage development of stormwater management strategies. This novel regional scale approach is demonstrated across a case study of the San Francisco Bay Area, spanning 8300 sq km. The main opportunity from this regional approach is to identify spatial and temporal trends which are used to inform regional planning and direct future detailed modelling efforts. The study highlights several limitations of the new method, suggesting it should be applied as part of a suite of landscape management approaches; however, highlights that it has the potential to complement existing stormwater management toolkitsNatural Capital ProjectEngineering and Physical Sciences Research Council (EPSRC)Natural Environment Research Council (NERC)Betty and Gordon Moore FoundationNanyang Technological University and National Research Foundation, Prime Minister’s Office, SingaporeEngineering School, Universidad de Buenos Aire

Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules

Background: Microenvironment cues involved in melanoma progression are largely unknown. Melanoma is highly influenced in its aggressive phenotype by the changes it determinates in its microenvironment, such as pH decrease, in turn influencing cancer cell invasiveness, progression and tissue remodelling through an abundant secretion of exosomes, dictating cancer strategy to the whole host. A role of exosomes in driving melanoma progression under microenvironmental acidity was never described. Methods: We studied four differently staged human melanoma lines, reflecting melanoma progression, under microenvironmental acidic pHs pressure ranging between pH 6.0-6.7. To estimate exosome secretion as a function of tumor stage and environmental pH, we applied a technique to generate native fluorescent exosomes characterized by vesicles integrity, size, density, markers expression, and quantifiable by direct FACS analysis. Functional roles of exosomes were tested in migration and invasion tests. Then we performed a comparative proteomic analysis of acid versus control exosomes to elucidate a specific signature involved in melanoma progression. Results: We found that metastatic melanoma secretes a higher exosome amount than primary melanoma, and that acidic pH increases exosome secretion when melanoma is in an intermediate stage, i.e. metastatic non-invasive. We were thus able to show that acidic pH influences the intercellular cross-talk mediated by exosomes. In fact when exposed to exosomes produced in an acidic medium, pH naïve melanoma cells acquire migratory and invasive capacities likely due to transfer of metastatic exosomal proteins, favoring cell motility and angiogenesis. A Prognoscan-based meta-analysis study of proteins enriched in acidic exosomes, identified 11 genes (HRAS, GANAB, CFL2, HSP90B1, HSP90AB1, GSN, HSPA1L, NRAS, HSPA5, TIMP3, HYOU1), significantly correlating with poor prognosis, whose high expression was in part confirmed in bioptic samples of lymph node metastases. Conclusions: A crucial step of melanoma progression does occur at melanoma intermediate -stage, when extracellular acidic pH induces an abundant release and intra-tumoral uptake of exosomes. Such exosomes are endowed with pro-invasive molecules of clinical relevance, which may provide a signature of melanoma advancement

Protective effect of stromal Dickkopf-3 in prostate cancer: opposing roles for TGFBI and ECM-1

Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is downregulated in prostate cancer and upregulated in the stroma in benign prostatic hyperplasia, but the function of stromal Dkk-3 is unclear. Here we show that DKK3 silencing in WPMY-1 prostate stromal cells increases TGF-β signaling activity and that stromal cellconditioned media inhibit prostate cancer cell invasion in a Dkk-3-dependent manner. DKK3 silencing increased the level of the cell-adhesion regulator TGF-β–induced protein (TGFBI) in stromal and epithelial cell-conditioned media, and recombinant TGFBI increased prostate cancer cell invasion. Reduced expression of Dkk-3 in patient tumors was associated with increased expression of TGFBI. DKK3 silencing reduced the level of extracellular matrix protein-1 (ECM-1) in prostate stromal cell-conditioned media but increased it in epithelial cell-conditioned media, and recombinant ECM-1 inhibited TGFBI-induced prostate cancer cell invasion. Increased ECM1 and DKK3 mRNA expression in prostate tumors was associated with increased relapse-free survival. These observations are consistent with a model in which the loss of Dkk-3 in prostate cancer leads to increased secretion of TGFBI and ECM-1, which have tumor-promoting and tumor-protective roles, respectively. Determining how the balance between the opposing roles of extracellular factors influences prostate carcinogenesis will be key to developing therapies that target the tumor microenvironment