A new model for market-based regulation of subnational borrowing - the Mexican approach

Faced with weak sub-national finances that pose a risk to macroeconomic stability, Mexico's federal government in April 2000 established an innovative incentive framework to bring fiscal discipline to state and municipal governments. That framework is based on two pillars: an explicit renunciation of federal bail-outs, and a Basel-consistent link between the capital-risk weighting of bank loans to sub-national governments, and the borrower's credit rating. In theory, this new regulatory arrangement should reduce moral hazard among banks and their state, and municipal clients; differentiate interest rates on the basis of the borrower's creditworthiness; and, elicit a strong demand for institutional development at the sub-national level. But its access will depend on three factors critical to implementation: 1) Whether markets find thefederal commitment not to bail out defaulting sub-national governments credible. 2) Whether sub-national governments have access to financing other than bank loans. 3) How well bank capital rules are enforced.Environmental Economics&Policies,Banks&Banking Reform,Payment Systems&Infrastructure,Economic Theory&Research,Financial Intermediation,Banks&Banking Reform,Economic Theory&Research,Environmental Economics&Policies,Financial Intermediation,Insurance&Risk Mitigation

Wildlife Deterrence Method Test Device

The objective of the Deer Busters team is to design and build a device or system of devices that will be used to determine which method, or methods, are most effective at deer deterrence. JumpSport suspects that a method which gives the appearance of approach to the deer in an aggressive or startling manner but also changes the way it attacks so that the deer do not get used to the device will be most effective. Deer Busters is committed to the completion of the deer deterrent testing device by the end of the fall quarter of 2014

An Investigation into the Role of Protein Kinases in T lymphocyte Migration

The migration of T lymphocytes is a vital component of the immune system, with roles in immunosurveillance and inflammation. The role of Phosphoinositide 3-kinase within T lymphocyte migration is unclear, with some evidence that it may be a disposable signal. Here, using Staphylococcal Enterotoxin B activated peripheral blood mononuclear cells and the T cell line CEM cells, the role of Phosphoinositide 3-kinase and its downstream kinases was investigated. CCL22 mediated CEM cell migration and CXCL12 mediated peripheral blood mononuclear cell migration were shown to be independent of Phosphoinositide 3-kinase using several different broad-spectrum Phosphoinositide 3-kinase inhibitors. However, these cells were Akt-dependent, as demonstrated by incubation with the Akt inhibitor Akti-1/2. Differences in the effect of the inhibitors on Akt activity were discovered, indicating that either Akt can be activated in the absence of Phosphoinositide 3-kinase, or differences exist regarding the relative abundance of each protein within the cell. Th17 cells are a subtype of the T helper cell family and have been shown to be involved in inflammation and immune diseases. Mouse splenocytes were polarised to a Th17 phenotype and analysed for the surface expression of chemokine receptors. CCR2, CCR6 and CCR9 were shown to be expressed on Th17 cells and upregulated under Th17 polarising conditions. However, only CCR2 and CCR6 induced migration of Th17 cells. This migration was sensitive to Phosphoinositide 3-kinase and Akt inhibitors. This data reveals a model for the migration of Th17 cells to areas of inflammation, and sheds light on the role of Phosphoinositide 3-kinase during this process.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

An investigation into the role of protein kinases in T lymphocyte migration

The migration of T lymphocytes is a vital component of the immune system, with roles in immunosurveillance and inflammation. The role of Phosphoinositide 3-kinase within T lymphocyte migration is unclear, with some evidence that it may be a disposable signal. Here, using Staphylococcal Enterotoxin B activated peripheral blood mononuclear cells and the T cell line CEM cells, the role of Phosphoinositide 3-kinase and its downstream kinases was investigated. CCL22 mediated CEM cell migration and CXCL12 mediated peripheral blood mononuclear cell migration were shown to be independent of Phosphoinositide 3-kinase using several different broad-spectrum Phosphoinositide 3-kinase inhibitors. However, these cells were Akt-dependent, as demonstrated by incubation with the Akt inhibitor Akti-1/2. Differences in the effect of the inhibitors on Akt activity were discovered, indicating that either Akt can be activated in the absence of Phosphoinositide 3-kinase, or differences exist regarding the relative abundance of each protein within the cell. Th17 cells are a subtype of the T helper cell family and have been shown to be involved in inflammation and immune diseases. Mouse splenocytes were polarised to a Th17 phenotype and analysed for the surface expression of chemokine receptors. CCR2, CCR6 and CCR9 were shown to be expressed on Th17 cells and upregulated under Th17 polarising conditions. However, only CCR2 and CCR6 induced migration of Th17 cells. This migration was sensitive to Phosphoinositide 3-kinase and Akt inhibitors. This data reveals a model for the migration of Th17 cells to areas of inflammation, and sheds light on the role of Phosphoinositide 3-kinase during this process.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Digitizing Sacks? Approaching social media as data

During the course of this article, we explore ethnomethodological principles in relation to approaching social media as data. More specifically, we consider the extent to which the work of Harvey Sacks and his rich intellectual legacy might inform this nascent field of empirical inquiry. This exploration is realised in the context of interdisciplinary research at the interface of social and computational science. Drawing from an extensive range of empirical projects into social media we reflect on the efficacy and limitations of these principles (Sacks, 1992) for understanding social media interaction as open data and practical action in the digital age

Problem Patron Policies in Public Libraries: A Content Analysis

This study examines the problem patron policy statements of twenty large and twenty small public libraries in order to find any commonalities and differences between policy content. Forty public libraries were selected based on legal service population and a content analysis was conducted on the patron conduct policies that were discovered. The researcher theorized that larger, urban library systems would have more anti-homeless policies and this theory was partially supported by the data. A significant finding of this study is the relative lack of correlation between library service population size and quantity and content of patron behavior policies