Cutting Edge : Failure of Antigen-Specific CD4+ T Cell Recruitment to the Kidney during Systemic Candidiasis

Copyright © 2014 The Authors. Acknowledgments We thank E. Bolton and H. Bagavant for reagents and advice. We also acknowledge the staff of the Medical Research Facility at the University of Aberdeen for care of the animals used in this study. This work was supported by the Medical Research Council and the Wellcome Trust.Peer reviewedPublisher PD

Managing Environmental and Economic Performance: a Review of Theory and Practice on Performance Measurement

As businesses struggle to maintain sustainability, a great deal of interest has focused on the issues of performance measurement systems. This paper provides a literature review on the evolution of performance measurement systems, from the traditional performance measures to the sustainable balanced scorecard. More importantly, this paper highlights the vital role of sustainable balanced scorecard as a tool that manages both economic and environmental performance. Majority of the existing sustainable balanced scorecard studies were found to be of normative nature giving limited information on how the integration process between economic and environmental dimensions is being carried out via balanced scorecard. Future research is needed to enhance the understanding of the role of the sustainable balanced scorecard as an important tool in the management of economic and environmental performance in the organization

Large Scale Structure in the SDSS Galaxy Survey

The Large Scale Structure (LSS) in the galaxy distribution is investigated using the Sloan Digital Sky Survey Early Data Release (SDSS EDR). Using the Minimal Spanning Tree technique we have extracted sets of filaments, of wall-like structures, of galaxy groups, and of rich clusters from this unique sample. The physical properties of these structures were then measured and compared with the expectations from Zel'dovich' theory. The measured characteristics of galaxy walls were found to be consistent with those for a spatially flat $\Lambda$CDM cosmological model with $\Omega_m\approx$ 0.3 and $\Omega_\Lambda \approx$ 0.7, and for Gaussian initial perturbations with a Harrison -- Zel'dovich power spectrum. Furthermore, we found that the mass functions of groups and of unrelaxed structure elements generally fit well with the expectations from Zel'dovich' theory, although there was some discrepancy for lower mass groups which may be due to incompleteness in the selected sample of groups. We also note that both groups and rich clusters tend to prefer the environments of walls, which tend to be of higher density, rather than the environments of filaments, which tend to be of lower density. Finally, we note evidence of systematic differences in the properties of the LSS between the Northern Galactic Cap stripe and the Southern Galactic Cap stripe -- in particular, in the physical properties of the walls, their spatial distribution, and the relative numbers of clusters embedded in walls. Because the mean separation of walls is $\approx$ 60 -- 70$h^{-1}$ Mpc, each stripe only intersects a few tens of walls. Thus, small number statistics and cosmic variance are the likely drivers of these systematic differences.Comment: 13 pages, 11 figures, MNRAS submitte

Targeting a heterologous protein to multiple plant organelles via rationally designed 5′ mRNA tags

Background: Plant bioengineers require simple genetic devices for predictable localization of heterologous proteins to multiple subcellular compartments. Results: We designed novel hybrid signal sequences for multiple-compartment localization and characterize their function when fused to GFP in Nicotiana benthamiana leaf tissue. TriTag-1 and TriTag-2 use alternative splicing to generate differentially localized GFP isoforms, localizing it to the chloroplasts, peroxisomes and cytosol. TriTag-1 shows a bias for targeting the chloroplast envelope while TriTag-2 preferentially targets the peroxisomes. TriTag-3 embeds a conserved peroxisomal targeting signal within a chloroplast transit peptide, directing GFP to the chloroplasts and peroxisomes. Conclusions: Our novel signal sequences can reduce the number of cloning steps and the amount of genetic material required to target a heterologous protein to multiple locations in plant cells. This work harnesses alternative splicing and signal embedding for engineering plants to express multi-functional proteins from single genetic constructs

Preliminary Evidence That CD38 Moderates the Association of Neuroticism on Amygdala-Subgenual Cingulate Connectivity.

CD38 genetic variation has been associated with autism spectrum disorders and social anxiety disorder, which may result from CD38's regulation of oxytocin secretion. Converging evidence has found that the rs3796863 A-allele contributes to increased social sensitivity compared to the CC genotype. The current study examined the moderating role of CD38 genetic variants (rs3796863 and rs6449182) that have been associated with enhanced (or reduced) social sensitivity on neural activation related to neuroticism, which is commonly elevated in individuals with social anxiety and depression. Adults (n = 72) with varying levels of social anxiety and depression provided biological samples for DNA extraction, completed a measure of neuroticism, and participated in a standardized emotion processing task (affect matching) while undergoing fMRI. A significant interaction effect was found for rs3796863 x neuroticism that predicted right amygdala-subgenual anterior cingulate cortex (sgACC) functional connectivity. Simple slopes analyses showed a positive association between neuroticism and right amygdala-sgACC connectivity among rs3796863 A-allele carriers. Findings suggest that the more socially sensitive rs3796863 A-allele may partially explain the relationship between a known risk factor (i.e. neuroticism) and promising biomarker (i.e. amygdala-sgACC connectivity) in the development and maintenance of social anxiety and depression

The effect of carbon and nutrient loading during nursery culture on the growth of black spruce seedlings: a six-year field study

Abstract We tested the effects of exponential nutrient loading and springtime carbon loading during nursery culture on the field performance of black spruce (Picea mariana (Mill.) B.S.P.). Seedlings were grown from seed with a conventional, fixed dose fertilizer (10 mg N seedling À1 ) or an exponential nutrient loading regime (75 mg N seedling À1 ). The following spring, seedlings were exposed for two weeks to either ambient (370 ppm) or elevated levels of CO 2 (800 ppm) and then planted in the field; seedling growth was followed for the next six years. Exponential nutrient loading increased seedling height, stem diameter and leader growth, with the largest increases in height and leader length occurring in the first three years after outplanting. Carbon loading increased seedling height and leader length, but only in seedlings that had been exponentially nutrient loaded. A combination of carbon and nutrient loading increased shoot height 26%, stem diameter 37% and leader length 40% over trees that received neither treatment. These results demonstrate that the growth enhancement seen under exponential nutrient loading is maintained under field conditions for at least six years. Carbon loading just before outplanting was a useful supplement to nutrient loading, but was ineffective in the absence of nutrient loading

Redshifts in the Southern Abell Redshift Survey Clusters. I. The Data

The Southern Abell Redshift Survey contains 39 clusters of galaxies with redshifts in the range 0.0 < z < 0.31 and a median redshift depth of z = 0.0845. SARS covers the region 0 21h (while avoiding the LMC and SMC) with b > 40. Cluster locations were chosen from the Abell and Abell-Corwin-Olowin catalogs while galaxy positions were selected from the Automatic Plate Measuring Facility galaxy catalog with extinction-corrected magnitudes in the range 15 <= b_j < 19. SARS utilized the Las Campanas 2.5 m duPont telescope, observing either 65 or 128 objects concurrently over a 1.5 sq deg field. New redshifts for 3440 galaxies are reported in the fields of these 39 clusters of galaxies.Comment: 20 pages, 5 figures, accepted for publication in the Astronomical Journal, Table 2 can be downloaded in its entirety from http://trotsky.arc.nasa.gov/~mway/SARS1/sars1-table2.cs