1,111 research outputs found
Fourier-domain low-coherence interferometry for light-scattering spectroscopy
We present a novel method for obtaining depth-resolved spectra for determining scatterer size through elastic- scattering properties. Depth resolution is achieved with a white-light source in a Michelson interferometer with the mixed signal and reference fields dispersed by a spectrograph. The spectrum is Fourier transformed to yield the axial spatial cross correlation between the signal and reference fields with near 1 m m depth resolution. Spectral information is obtained by windowing to yield the scattering amplitude as a function of wave number. The technique is demonstrated by determination of the size of polystyrene microspheres in a subsurface layer with subwavelength accuracy. Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed
Direct measurement of spatial Wigner function with area-integrated detection
We demonstrate experimentally a novel technique for characterizing transverse
spatial coherence using the Wigner distribution function. The presented method
is based on measuring interference between a pair of rotated and displaced
replicas of the input beam with an area-integrating detector, and it can be
superior in regimes when array detectors are not available. We analyze the
quantum optical picture of the presented measurement for single-photon signals
and discuss possible applications in quantum information processing.Comment: 3 pages, REVTe
Characterization of a periodically driven chaotic dynamical system
We discuss how to characterize the behavior of a chaotic dynamical system
depending on a parameter that varies periodically in time. In particular, we
study the predictability time, the correlations and the mean responses, by
defining a local--in--time version of these quantities. In systems where the
time scale related to the time periodic variation of the parameter is much
larger than the ``internal'' time scale, one has that the local quantities
strongly depend on the phase of the cycle. In this case, the standard global
quantities can give misleading information.Comment: 15 pages, Revtex 2.0, 8 figures, included. All files packed with
uufile
Application of remote sensing to state and regional problems
The author has identified the following significant results. The Lowndes County data base is essentially complete with 18 primary variables and 16 proximity variables encoded into the geo-information system. The single purpose, decision tree classifier is now operational. Signatures for the thematic extraction of strip mines from LANDSAT Digital data were obtained by employing both supervised and nonsupervised procedures. Dry, blowing sand areas of beach were also identified from the LANDSAT data. The primary procedure was the analysis of analog data on the I2S signal slicer
A phase Ib/II study of cabozantinib (XL184) with or without erlotinib in patients with non-small cell lung cancer.
PurposeCabozantinib is a multi-kinase inhibitor that targets MET, AXL, and VEGFR2, and may synergize with EGFR inhibition in NSCLC. Cabozantinib was assessed alone or in combination with erlotinib in patients with progressive NSCLC and EGFR mutations who had previously received erlotinib.MethodsThis was a phase Ib/II study (NCT00596648). The primary objectives of phase I were to assess the safety, pharmacokinetics, and pharmacodynamics and to determine maximum tolerated dose (MTD) of cabozantinib plus erlotinib in patients who failed prior erlotinib treatment. In phase II, patients with prior response or stable disease with erlotinib who progressed were randomized to single-agent cabozantinib 100 mg qd vs cabozantinib 100 mg qd and erlotinib 50 mg qd (phase I MTD), with a primary objective of estimating objective response rate (ORR).ResultsSixty-four patients were treated in phase I. Doses of 100 mg cabozantinib plus 50 mg erlotinib, or 40 mg cabozantinib plus 150 mg erlotinib were determined to be MTDs. Diarrhea was the most frequent dose-limiting toxicity and the most frequent AE (87.5% of patients). The ORR for phase I was 8.2% (90% CI 3.3-16.5). In phase II, one patient in the cabozantinib arm (N = 15) experienced a partial response, for an ORR of 6.7% (90% CI 0.3-27.9), with no responses for cabozantinib plus erlotinib (N = 13). There was no evidence that co-administration of cabozantinib markedly altered erlotinib pharmacokinetics or vice versa.ConclusionsDespite responses with cabozantinib/erlotinib in phase I, there were no responses in the combination arm of phase II in patients with acquired resistance to erlotinib. Cabozantinib did not appear to re-sensitize these patients to erlotinib
Penetration depth of low-coherence enhanced backscattered light in sub-diffusion regime
The mechanisms of photon propagation in random media in the diffusive
multiple scattering regime have been previously studied using diffusion
approximation. However, similar understanding in the low-order (sub-diffusion)
scattering regime is not complete due to difficulties in tracking photons that
undergo very few scatterings events. Recent developments in low-coherence
enhanced backscattering (LEBS) overcome these difficulties and enable probing
photons that travel very short distances and undergo only a few scattering
events. In LEBS, enhanced backscattering is observed under illumination with
spatial coherence length L_sc less than the scattering mean free path l_s. In
order to understand the mechanisms of photon propagation in LEBS in the
subdiffusion regime, it is imperative to develop analytical and numerical
models that describe the statistical properties of photon trajectories. Here we
derive the probability distribution of penetration depth of LEBS photons and
report Monte Carlo numerical simulations to support our analytical results. Our
results demonstrate that, surprisingly, the transport of photons that undergo
low-order scattering events has only weak dependence on the optical properties
of the medium (l_s and anisotropy factor g) and strong dependence on the
spatial coherence length of illumination, L_sc, relative to those in the
diffusion regime. More importantly, these low order scattering photons
typically penetrate less than l_s into the medium due to low spatial coherence
length of illumination and their penetration depth is proportional to the
one-third power of the coherence volume (i.e. [l_s \pi L_sc^2 ]^1/3).Comment: 32 pages(including 7 figures), modified version to appear in Phys.
Rev.
The Excursion Set Theory of Halo Mass Functions, Halo Clustering, and Halo Growth
I review the excursion set theory (EST) of dark matter halo formation and
clustering. I recount the Press-Schechter argument for the mass function of
bound objects and review the derivation of the Press-Schechter mass function in
EST. The EST formalism is powerful and can be applied to numerous problems. I
review the EST of halo bias and the properties of void regions. I spend
considerable time reviewing halo growth in the EST. This section culminates
with descriptions of two Monte Carlo methods for generating halo mass accretion
histories. In the final section, I emphasize that the standard EST approach is
the result of several simplifying assumptions. Dropping these assumptions can
lead to more faithful predictions and a more versatile formalism. One such
assumption is the constant height of the barrier for nonlinear collapse. I
review implementations of the excursion set approach with arbitrary barrier
shapes. An application of this is the now well-known improvement to standard
EST that follows from the ellipsoidal-collapse barrier. Additionally, I
emphasize that the statement that halo accretion histories are independent of
halo environments is a simplifying assumption, rather than a prediction of the
theory. I review the method for constructing correlated random walks of the
density field in more general cases. I construct a simple toy model with
correlated walks and I show that excursion set theory makes a qualitatively
simple and general prediction for the relation between halo accretion histories
and halo environments: regions of high density preferentially contain
late-forming halos and conversely for regions of low density. I conclude with a
brief discussion of this prediction in the context of recent numerical studies
of the environmental dependence of halo properties. (Abridged)Comment: 62 pages, 19 figures. Review article based on lectures given at the
Sixth Summer School of the Helmholtz Institute for Supercomputational
Physics. Accepted for Publication in IJMPD. Comments Welcom
- …