Память и мемуары: прошлое как чужая страна

The posthumous publication of Iurii Dmitrievich Rykov’s most important contributions to the study of the writings of Prince Andrei Kurbskii (including for the first time his kandidat dissertation) has inspired this essay as a tribute to Rykov, one of the leading specialists on early Russian manuscripts. Rather than focus on the substance of the Kurbskii material, the emphasis is on Rykov’s own memoir in the book and more generally on memoirs as historical sources, among them ones written by the noted scholars S. V. Zhitomirskaia and A. A. Zimin. Appended to the essay are a number of letters which Rykov wrote to his American colleagues. DOI: 10.31168/2305-6754.2021.11.1.18Посмертное издание важнейших исследований Ю. Д. Рыкова (включая и его неопубликованную кандидатскую диссертацию) о сочинениях кн. А. М. Курбского послужило поводом писать в память выдающегося специалиста в изучении древнерусских рукописей. Статья сосредоточится не на сложные вопросы о Курбском, а на анализ воспоминания Рыкова и источниковедческих вопросов о мемуарах, включая и воспоминания известных ученых С. В. Житомирской и А. А. Зимина. В приложении опубликованы письма Рыкова американским коллегам. DOI: 10.31168/2305-6754.2021.11.1.1

Еще раз о «Вызове великого турка»

Four decades after his monograph on the apocryphal correspondence of the Ottoman sultan was published, the author reviews the previous study of the subject, the origins of his book, its skeptical reception then, and the current acceptance of its main argument that most of the Russian versions of that correspondence are translations from Western European pamphlets and newspapers. Recent scholarship has located additional proof, and the current article presents further information which should help identify the sources for some of the Russian texts. DOI: 10.31168/2305-6754.2019.8.1.6По случаю сорокалетия публикации своей монографии о легендарной переписке турецкого султана автор в настоящей статье рассматривает историю изучения предмета, рассказывает о возникновении своей книги, о ее первоначальном скептическом приеме и о нынешнем согласии ученых с ее главным аргументом о том, что большинство русских текстов переписки являются переводами с западных газет и брошюр. Новые исследования обнаружили дополнительные доказательства этой концепции, и в настоящей статье описываются новые материалы, которые должны содействовать находке источников некоторых русских текстов. DOI: 10.31168/2305-6754.2019.8.1.

Quantum Computation with Quantum Dots

We propose a new implementation of a universal set of one- and two-qubit gates for quantum computation using the spin states of coupled single-electron quantum dots. Desired operations are effected by the gating of the tunneling barrier between neighboring dots. Several measures of the gate quality are computed within a newly derived spin master equation incorporating decoherence caused by a prototypical magnetic environment. Dot-array experiments which would provide an initial demonstration of the desired non-equilibrium spin dynamics are proposed.Comment: 12 pages, Latex, 2 ps figures. v2: 20 pages (very minor corrections, substantial expansion), submitted to Phys. Rev.

Localization of interacting electrons in quantum dot arrays driven by an ac-field

We investigate the dynamics of two interacting electrons moving in a one-dimensional array of quantum dots under the influence of an ac-field. We show that the system exhibits two distinct regimes of behavior, depending on the ratio of the strength of the driving field to the inter-electron Coulomb repulsion. When the ac-field dominates, an effect termed coherent destruction of tunneling occurs at certain frequencies, in which transport along the array is suppressed. In the other, weak-driving, regime we find the surprising result that the two electrons can bind into a single composite particle -- despite the strong Coulomb repulsion between them -- which can then be controlled by the ac-field in an analogous way. We show how calculation of the Floquet quasienergies of the system explains these results, and thus how ac-fields can be used to control the localization of interacting electron systems.Comment: 7 pages, 6 eps figures V2. Minor changes, this version to be published in Phys. Rev.

Coupled quantum dots as quantum gates

We consider a new quantum gate mechanism based on electron spins in coupled semiconductor quantum dots. Such gates provide a general source of spin entanglement and can be used for quantum computers. We determine the exchange coupling J in the effective Heisenberg model as a function of magnetic (B) and electric fields, and of the inter-dot distance (a) within the Heitler-London approximation of molecular physics. This result is refined by using sp-hybridization, and by the Hund-Mulliken molecular-orbit approach which leads to an extended Hubbard description for the two-dot system that shows a remarkable dependence on B and a due to the long-range Coulomb interaction. We find that the exchange J changes sign at a finite field (leading to a pronounced jump in the magnetization) and then decays exponentially. The magnetization and the spin susceptibilities of the coupled dots are calculated. We show that the dephasing due to nuclear spins in GaAs can be strongly suppressed by dynamical nuclear spin polarization and/or by magnetic fields.Comment: 10 pages, 4 figures. v2: minor corrections, appendix added. to be published in Phys.Rev.

Spin interactions and switching in vertically tunnel-coupled quantum dots

We determine the spin exchange coupling J between two electrons located in two vertically tunnel-coupled quantum dots, and its variation when magnetic (B) and electric (E) fields (both in-plane and perpendicular) are applied. We predict a strong decrease of J as the in-plane B field is increased, mainly due to orbital compression. Combined with the Zeeman splitting, this leads to a singlet-triplet crossing, which can be observed as a pronounced jump in the magnetization at in-plane fields of a few Tesla, and perpendicular fields of the order of 10 Tesla for typical self-assembled dots. We use harmonic potentials to model the confining of electrons, and calculate the exchange J using the Heitler-London and Hund-Mulliken technique, including the long-range Coulomb interaction. With our results we provide experimental criteria for the distinction of singlet and triplet states and therefore for microscopic spin measurements. In the case where dots of different sizes are coupled, we present a simple method to switch on and off the spin coupling with exponential sensitivity using an in-plane electric field. Switching the spin coupling is essential for quantum computation using electronic spins as qubits.Comment: 13 pages, 9 figure

Hallmarks of the Mott-Metal Crossover in the Hole-Doped Pseudospin-1/2 Mott Insulator Sr\u3csub\u3e2\u3c/sub\u3eIrO\u3csub\u3e4\u3c/sub\u3e

The physics of doped Mott insulators remains controversial after decades of active research, hindered by the interplay among competing orders and fluctuations. It is thus highly desired to distinguish the intrinsic characters of the Mott-metal crossover from those of other origins. Here we investigate the evolution of electronic structure and dynamics of the hole-doped pseudospin-1/2 Mott insulator Sr2IrO4. The effective hole doping is achieved by replacing Ir with Rh atoms, with the chemical potential immediately jumping to or near the top of the lower Hubbard band. The doped iridates exhibit multiple iconic low-energy features previously observed in doped cuprates—pseudogaps, Fermi arcs and marginal-Fermi-liquid-like electronic scattering rates. We suggest these signatures are most likely an integral part of the material’s proximity to the Mott state, rather than from many of the most claimed mechanisms, including preformed electron pairing, quantum criticality or density-wave formation

Aptamer-based multiplexed proteomic technology for biomarker discovery

Interrogation of the human proteome in a highly multiplexed and efficient manner remains a coveted and challenging goal in biology. We present a new aptamer-based proteomic technology for biomarker discovery capable of simultaneously measuring thousands of proteins from small sample volumes (15 [mu]L of serum or plasma). Our current assay allows us to measure ~800 proteins with very low limits of detection (1 pM average), 7 logs of overall dynamic range, and 5% average coefficient of variation. This technology is enabled by a new generation of aptamers that contain chemically modified nucleotides, which greatly expand the physicochemical diversity of the large randomized nucleic acid libraries from which the aptamers are selected. Proteins in complex matrices such as plasma are measured with a process that transforms a signature of protein concentrations into a corresponding DNA aptamer concentration signature, which is then quantified with a DNA microarray. In essence, our assay takes advantage of the dual nature of aptamers as both folded binding entities with defined shapes and unique sequences recognizable by specific hybridization probes. To demonstrate the utility of our proteomics biomarker discovery technology, we applied it to a clinical study of chronic kidney disease (CKD). We identified two well known CKD biomarkers as well as an additional 58 potential CKD biomarkers. These results demonstrate the potential utility of our technology to discover unique protein signatures characteristic of various disease states. More generally, we describe a versatile and powerful tool that allows large-scale comparison of proteome profiles among discrete populations. This unbiased and highly multiplexed search engine will enable the discovery of novel biomarkers in a manner that is unencumbered by our incomplete knowledge of biology, thereby helping to advance the next generation of evidence-based medicine

Constitutive and Treatment-Induced CXCL8-Signalling Selectively Modulates the Efficacy of Anti-Metabolite Therapeutics in Metastatic Prostate Cancer

<div><h3>Background</h3><p>The current study was undertaken to characterize the effect of anti-metabolites on inducing CXCL8 signaling and determining whether the constitutive and/or drug-induced CXCL8 signaling in metastatic prostate cancer (CaP) cells modulates their sensitivity to this class of agent.</p> <h3>Methods</h3><p>The response of metastatic CaP cells to 5-Fluorouracil (5-FU), Pemetrexed or Tomudex was determined using cell count assays, flow cytometry and PARP cleavage analysis. Quantitative-PCR, ELISA and immunoblots were employed to determine effects of drugs or CXCL8 administration on target gene/protein expression.</p> <h3>Results</h3><p>Administration of 5-FU but not pemetrexed potentiated CXCL8 secretion and increased CXCR1 and CXCR2 gene expression in metastatic PC3 cells. Consistent with this, the inhibition of CXCL8 signaling using a CXCR2 antagonist, AZ10397767, increased the cytotoxicity of 5-FU by 4-fold (P<0.001), and increased 5-FU-induced apoptosis in PC3 cells (P<0.01). In contrast, while administration of AZ10397767 had no effect on the sensitivity of pemetrexed, the CXCR2 antagonist exerted the greatest effect in increasing the sensitivity of PC3 cells to Tomudex, a directed thymidylate synthase (TS) inhibitor. Subsequent experiments confirmed that administration of recombinant human CXCL8 increased TS expression, a response mediated in part by the CXCR2 receptor. Moreover, siRNA-mediated knockdown of the CXCL8-target gene Bcl-2 increased the sensitivity of PC3 cells to 5-FU.</p> <h3>Conclusions</h3><p>CXCL8 signaling provides a selective resistance of metastatic prostate cancer cells to specific anti-metabolites by promoting a target-associated resistance, in addition to underpinning an evasion of treatment-induced apoptosis.</p> </div