Азотемическое распятие медицины и дезорганизация почечных функций как функциональная рекапитуляция

ФИЗИОЛОГИЯПОЧЕЧНАЯ НЕДОСТАТОЧНОСТЬ /ДИАГНОСТИКАПОЧКИ /РОСТ И РАЗВИТИЕ /ФИЗИОЛОГИЯПАТОЛОГИЧЕСКАЯ ФИЗИОЛОГИЯНЕФРОЛОГИЯВ монографии представлена трактовка диагностики начальных стадий почечной недостаточности как нерешенная клиническая проблема, а также возможность использования эволюционных закономерностей развития почечных функций как критериев оценки функциональных характеристик почечной деятельности

DERIVE AND INTEGRATE SUSTAINABILITY CRITERIA IN DESIGN SPACE EXPLORATION OF ADDITIVE MANUFACTURED COMPONENTS

Additive manufacturing has the potential to decrease the climate impact of aviation by providing more light-weight designs. Sustainability is however required to be assessed from a systemic view, including all lifecycle phases, and from a social, ecologic, and economic dimension. This is however challenging in early phase design, where also a large design space need to be explored. A case study is carried out with an aerospace company where two candidate engineering design tools are combined to address this. The integration of these two engineering tools are applied on a Turbine Rear Structure, and shows promising results in enabling a systemic view of sustainability to be integrated and assessed in early phase design space explorations of additive manufactured components. It is recommended that the integration between the two tools is further established and validated

Småskalig vedeldning, cancerriskfrekvenser och kostnader i Sverige : En undersökning av styrmedel med MCA metodik

Air pollution cause approximately 5000 premature deaths in Sweden each year. Residential wood combustion of solid biomass (RWC) is responsible for at least 1000 based on a relative risk coefficient of 17 % per 10 μg/m3 exposure. The carcinogenic properties of RWC emissions is linked to their content of particulates and polycyclic aromatic hydrocarbons (PAH’s). The ambition of this study is to answer whether cancer risk may be used as indicator for out dated heating technology with high emissions of carcinogenic air pollutants, and which socioeconomic costs that can be linked to such a scenario. The efficacy of different instruments that are discussed in Swedish environmental policy is also discussed. A transdisciplinary approach, constituting of a literature review, statistical analysis, gap analysis and multi criteria analysis was applied as study design. A literature review resulted in a mapping of the state of the art concerning RWC particulates and their impact on cancer in Sweden together with its related socioeconomic costs. The study is focused on PM2,5 and B(a)P emissions. A statistical analysis examined the potential relationship between short-lived micro nuclei (MN) in Swedish 12-year old school children, and their exposure to the carcinogenic PAH Benzo(a)pyrene (B(a)P) from RWC in Sweden. The results suggest that higher rates of lung cancer incidence, and socioeconomic costs may be found in areas burdened with high rates of RWC emissions from outdated heating technology. The MCA suggest that a combination of instruments is most suitable to achieve the targeted specification for B(a)P in the Clean Air objective, as found in previous CBA’s, and that other instrument may lack efficacy.Varje år orsakar luftföroreningar omkring 5000 prematura dödsfall i Sverige. Småskalig vedeldning (RWC) ansvarar för åtminstone 1000 av dessa, baserat på den relativa risk-koefficienten 17 % per 10 μg/m3 exponering. De cancerogena egenskaperna hos vedeldningsutsläpp beror bland annat på dess partiklar som bland annat innehåller polycykliska aromatiska kolväten (PAH:er). Ambitionen med denna studie är att besvara hur framtida cancerrisk kan användas som indikator för luftföroreningar från omodern uppvärmningsteknik och vilka samhällsekonomiska följder som kan länkas till en sådan. Dessutom undersöktes styrkraften hos de styrmedel som diskuteras i svensk miljöpolicy. Med hjälp av ett tvärvetenskapligt tillvägagångssätt, bestående av litteraturgenomgång, statistisk analys, gapanalys och multikriterieanalys besvarades frågorna. Litteraturgenomgången resulterade i en kartläggning av det nuvarande kunskapsläget om vedpartiklars påverkan på cancer i Sverige och dess relaterade samhällskostnader. Studien är fokuserad på PM2,5 och B(a)P emissioner. En statistisk analys undersökte korrelationen mellan en biomarkor för framtida cancerrisk, kortlivade mikrokärnor (MN), hos svenska 12-åriga skolelever, och deras vedröksexponering. Resultaten indikerar svagt att större risk för lungcancer kan spås i områden med relativt högre exponering för vedrökskomponenten B(a)P, alltså områden med omodern uppvärmningsutrustning. Multikriterieanalysen visar, liksom i tidigare kostnad-effektivitetsanalyser, att en kombination av olika styrmedel har störst potential att uppnå specifikationerna för PM2,5 och B(a)P i det svenska miljökvalitetsmålet Ren luft. Andra styrmedel kan sakna styrkraft

Utilizing requirements to support sustainable product development : Introductory approaches for strategic sustainability integration

The attention to sustainability impacts arising during the lifecycle of products is growing as industry wants to increase its contribution to a sustainable society. To do so, companies must find ways to navigate the complexity of the needs within the socio-ecological system in which they operate. In engineering design projects, the interpretation of needs into requirements is essential, as they represent the collective understanding of the design problem to be solved. Ideally, requirements are possible to verify and validate, which makes it challenging for industry to integrate socio-ecological considerations, often based on qualitative models, into requirements. Sustainability then tends not to be prioritized in trade-offs with traditionally identified requirements for engineering design. A qualitative research approach within design research methodology framed a sequence of studies guided by the research question ‘How can requirements be utilized to support Sustainable Product Development?’ First, a research gap was identified from a literature review which indicated a lack of socio-ecological systems contextualization in the identification, as well as the traceability of sustainability criteria to integrate into requirements. Secondly, a conceptual model was established for how management of requirements can be improved to facilitate traceability, as well as how contextual socio-ecological systems perspective can be introduced in the selection, of sustainability criteria for engineering design projects. For this purpose, the results from a multiple-case study based on semi-structured interviews with seven design and manufacturing companies was triangulated with findings of an in-depth literature analysis. Five key elements of management of sustainability in requirements were proposed in a profile model corresponding to different levels of sustainability maturity. A third study explored, based on literature and prototype causal loop diagramming, the potential of a group model building approach to enhance contextual understanding of strategically identified, i.e., company-tailored, sustainability criteria in relation to traditional requirements in early phases of the product innovation process. A final study investigated how a strategic sustainability perspective can be integrated with engineering design methods and value modelling to create a decision support for concept selection. The studies together indicate that key constituents of good requirements, traceability and systems contextualization, can be achieved also for socio-ecological sustainability considerations. This requires organizational commitment and will be reflected in the design of the operational management system for their product innovation process. Following the proposed five key elements of sustainability integration in requirements, a company is expected to increase the organizational sustainability maturity, and hence its capability to contribute to a sustainability transition. This research also shows that there is a gap in current methods and tools for enhanced socio-ecological systems contextualization. The two last studies of this thesis give promising approaches of tools and methods to be further developed and analyzed, namely group model building, system analysis and value modelling

Using Group Model Building to Foster Learning for Strategic Sustainable Development

Capability for strategic planning and decision-making toward sustainability requires both individuals and organizations from different sectors and disciplines to develop necessary skills and competencies. Therefore, a growing discussion has emerged within academia and practice around how pedagogical methods and tools can be utilized for this purpose. This paper seeks to contribute to this discussion by asking ‘in which way may group model building be used to foster learning that leads to competency for strategic sustainable development?’. The potential of the group model building (GMB) process’ steps and associated modeling to foster learning for strategic sustainable development (SSD) was analyzed using four case examples. Theory on learning for sustainability and key sustainability competencies were linked to elements of a process for strategic planning toward sustainability within the framework for strategic sustainable development (FSSD) as a reference model. The results provide a discussion on how GMB can be utilized to foster sustainability competencies and learning for sustainability that can contribute to SSD, hence a basis for continued research and ideas for course and curriculum development.open access</p

Towards sustainable product development through a lens of requirements

Product development companies’ attention and desire to contribute to sustainable development is growing fast but requires new capabilities. The socioecological systems constitute a complex landscape of operating conditions from which product development identify needs for new products. Correct needs interpretation is essential to ensure that the requirements that the needs are transformed into do represent the shared understanding of the design problem that is to be solved. However, companies find it challenging to integrate sustainability into requirements. Socioecological criteria therefore tend to be down prioritized in trade-offs with traditionally identified requirements for engineering design. This thesis asks the following question: “In which ways can decision-making practices for requirements development and management support sustainable product development?” and aims to provide deeper knowledge to academia and support product development companies that wish to advance their contribution to sustainable development. A mainly qualitative research design using exploratory, descriptive, and prescriptive studies clarifies the research gap, and proposes and evaluates novel approaches to improve the state of knowledge and practice. These research studies are represented by the seven publications within this thesis. The first was a systematic literature review on current methods and tools for sustainability integration into requirements. Thereafter followed a multiple-case study with semi-structured interviews at seven Swedish product development companies. A model of five key elements of sustainability integration in requirements was proposed, which in a third, focus group case study with four companies, was developed into, and tested as, a self-assessment tool. The results were discussed in relation to theory on requirements engineering and sustainability design criteria, which emphasized that companies lack capabilities to contextualize requirements development using wider sustainability- and systems perspectives. Decision-makers responsible for requirements weighting need to anchor sustainability as a value driver which requires transparency and traceability in decision-support. A fourth study therefore explored sustainability integration in value modelling for concept selection, and a fifth study proposed an approach to guide sustainability criteria development following requirement characteristics. The sixth study proposed an approach to inform requirement analysis through improved systems contextualization, transparency, and shared understanding of sustainability in relation to other design objectives. Finally, the seventh study provided an outlook and initial discussion to guide the identification of value drivers on a macro-level in society which could leverage an increased uptake of sustainability-oriented requirements in product development Altogether this thesis provides insights and approaches to guide companies to advance towards sustainable product development through the lens of requirements. Examples include key characteristics of, and principles for, identifying sustainability criteria and developing requirements using strategic sustainability thinking, as well as a support tool for guiding activities in different steps of the requirements development. The findings can also be used in education of future engineers and decision-makers, and for continued research

Towards sustainable product development through a lens of requirements

Product development companies’ attention and desire to contribute to sustainable development is growing fast but requires new capabilities. The socioecological systems constitute a complex landscape of operating conditions from which product development identify needs for new products. Correct needs interpretation is essential to ensure that the requirements that the needs are transformed into do represent the shared understanding of the design problem that is to be solved. However, companies find it challenging to integrate sustainability into requirements. Socioecological criteria therefore tend to be down prioritized in trade-offs with traditionally identified requirements for engineering design. This thesis asks the following question: “In which ways can decision-making practices for requirements development and management support sustainable product development?” and aims to provide deeper knowledge to academia and support product development companies that wish to advance their contribution to sustainable development. A mainly qualitative research design using exploratory, descriptive, and prescriptive studies clarifies the research gap, and proposes and evaluates novel approaches to improve the state of knowledge and practice. These research studies are represented by the seven publications within this thesis. The first was a systematic literature review on current methods and tools for sustainability integration into requirements. Thereafter followed a multiple-case study with semi-structured interviews at seven Swedish product development companies. A model of five key elements of sustainability integration in requirements was proposed, which in a third, focus group case study with four companies, was developed into, and tested as, a self-assessment tool. The results were discussed in relation to theory on requirements engineering and sustainability design criteria, which emphasized that companies lack capabilities to contextualize requirements development using wider sustainability- and systems perspectives. Decision-makers responsible for requirements weighting need to anchor sustainability as a value driver which requires transparency and traceability in decision-support. A fourth study therefore explored sustainability integration in value modelling for concept selection, and a fifth study proposed an approach to guide sustainability criteria development following requirement characteristics. The sixth study proposed an approach to inform requirement analysis through improved systems contextualization, transparency, and shared understanding of sustainability in relation to other design objectives. Finally, the seventh study provided an outlook and initial discussion to guide the identification of value drivers on a macro-level in society which could leverage an increased uptake of sustainability-oriented requirements in product development Altogether this thesis provides insights and approaches to guide companies to advance towards sustainable product development through the lens of requirements. Examples include key characteristics of, and principles for, identifying sustainability criteria and developing requirements using strategic sustainability thinking, as well as a support tool for guiding activities in different steps of the requirements development. The findings can also be used in education of future engineers and decision-makers, and for continued research

Using Group Model Building to Foster Learning for Strategic Sustainable Development

Capability for strategic planning and decision-making toward sustainability requires both individuals and organizations from different sectors and disciplines to develop necessary skills and competencies. Therefore, a growing discussion has emerged within academia and practice around how pedagogical methods and tools can be utilized for this purpose. This paper seeks to contribute to this discussion by asking &lsquo;in which way may group model building be used to foster learning that leads to competency for strategic sustainable development?&rsquo;. The potential of the group model building (GMB) process&rsquo; steps and associated modeling to foster learning for strategic sustainable development (SSD) was analyzed using four case examples. Theory on learning for sustainability and key sustainability competencies were linked to elements of a process for strategic planning toward sustainability within the framework for strategic sustainable development (FSSD) as a reference model. The results provide a discussion on how GMB can be utilized to foster sustainability competencies and learning for sustainability that can contribute to SSD, hence a basis for continued research and ideas for course and curriculum development

Utilizing requirements to support sustainable product development : Introductory approaches for strategic sustainability integration

The attention to sustainability impacts arising during the lifecycle of products is growing as industry wants to increase its contribution to a sustainable society. To do so, companies must find ways to navigate the complexity of the needs within the socio-ecological system in which they operate. In engineering design projects, the interpretation of needs into requirements is essential, as they represent the collective understanding of the design problem to be solved. Ideally, requirements are possible to verify and validate, which makes it challenging for industry to integrate socio-ecological considerations, often based on qualitative models, into requirements. Sustainability then tends not to be prioritized in trade-offs with traditionally identified requirements for engineering design. A qualitative research approach within design research methodology framed a sequence of studies guided by the research question ‘How can requirements be utilized to support Sustainable Product Development?’ First, a research gap was identified from a literature review which indicated a lack of socio-ecological systems contextualization in the identification, as well as the traceability of sustainability criteria to integrate into requirements. Secondly, a conceptual model was established for how management of requirements can be improved to facilitate traceability, as well as how contextual socio-ecological systems perspective can be introduced in the selection, of sustainability criteria for engineering design projects. For this purpose, the results from a multiple-case study based on semi-structured interviews with seven design and manufacturing companies was triangulated with findings of an in-depth literature analysis. Five key elements of management of sustainability in requirements were proposed in a profile model corresponding to different levels of sustainability maturity. A third study explored, based on literature and prototype causal loop diagramming, the potential of a group model building approach to enhance contextual understanding of strategically identified, i.e., company-tailored, sustainability criteria in relation to traditional requirements in early phases of the product innovation process. A final study investigated how a strategic sustainability perspective can be integrated with engineering design methods and value modelling to create a decision support for concept selection. The studies together indicate that key constituents of good requirements, traceability and systems contextualization, can be achieved also for socio-ecological sustainability considerations. This requires organizational commitment and will be reflected in the design of the operational management system for their product innovation process. Following the proposed five key elements of sustainability integration in requirements, a company is expected to increase the organizational sustainability maturity, and hence its capability to contribute to a sustainability transition. This research also shows that there is a gap in current methods and tools for enhanced socio-ecological systems contextualization. The two last studies of this thesis give promising approaches of tools and methods to be further developed and analyzed, namely group model building, system analysis and value modelling

Towards sustainable product development – Insights from testing and evaluating a profile model for management of sustainability integration into design requirements

Product development and manufacturing continues to be a profound contributor to the socio-ecological problems and challenges we are facing in our world today. For products to contribute to sustainability requires not only that socio-ecological lifecycle impacts are considered in the initial stages of the product innovation process, but that they are maintained as integral product requirements. Although research offers a plethora of approaches, methods, and tools for sustainable product development, the implementation in industry remains low. The focus of this research is a less explored area of sustainable product development implementation, the management of needs identification and propagation of design requirements. The purpose is to: i) add to state of knowledge about current practices of sustainability integration into requirements, and ii) the academic discussion on implementation of sustainable design and product development. A self-assessment approach for sustainability integration into requirements is tested. The purpose of the approach is to support improvement of the requirements management process design, including activities and competencies, for engineering design. Four Swedish product development and manufacturing companies tested the approach, from which the results are used to evaluate usefulness, usability, and effect potential. The findings are discussed together with key characteristics for requirements and sustainability criteria, providing insights to ensure that socio-ecological considerations are both influencing the initial requirement specification, and maintained as decision parameters throughout the product development process.open access</p