167 research outputs found
Structural Classification of Metal Complexes with Three-Coordinate Centres
Attempts to describe the geometry about three-coordinate silver(I) complexes have proven difficult because interatomic angles generally vary wildly and there is no adequate or readily available classification system found in the literature. A search of the Cambridge Structural Database shows that complexes formed between any metal centre and three non-metal donors (18001 examples) usually adopt geometries that are quite different than ideal ‘textbook’ extremes of either trigonal planar (∼4% with α = β = γ = 120 ± 2°), T-shaped (∼0.05% with α = 180 ± 2°, β = γ = 90 ± 2°), or trigonal pyramidal (∼0.3% with α = β = γ = 110 ± 2°). Moreover, there are multiple variations of “Y-type” and “other” shapes that require elaboration. Thus, to assist in future structural descriptions, we developed a classification system that spans all known and yet-to-be-discovered three-coordinate geometries. A spreadsheet has also been constructed that utilizes the “shape-space” approach to extract the structural description from a user input of three angles about a tri-coordinate centre and the number of atoms in a plane. The structures of two silver(I) complexes of new N-donor ligands p-NH2C6H4C6H4CH(pz = pyrazol-1-yl)2, L1, and 2-ferrocenyl-4,5-di(2-pyridyl)imidazole, L2, illustrate the utility of this classification system
Clinical and Molecular Aspects of Senataxin Mutations in Amyotrophic Lateral Sclerosis 4
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154673/1/ana25681_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154673/2/ana25681.pd
PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
CD4+ T cell differentiation into multiple T helper (Th) cell lineages is critical for optimal adaptive immune responses. This report identifies an intrinsic mechanism by which programmed death-1 receptor (PD-1) signaling imparted regulatory phenotype to Foxp3+ Th1 cells (denoted as Tbet+iTregPDL1 cells) and inducible regulatory T (iTreg) cells. Tbet+iTregPDL1 cells prevented inflammation in murine models of experimental colitis and experimental graft versus host disease (GvHD). Programmed death ligand-1 (PDL-1) binding to PD-1 imparted regulatory function to Tbet+iTregPDL1 cells and iTreg cells by specifically downregulating endo-lysosomal protease asparaginyl endopeptidase (AEP). AEP regulated Foxp3 stability and blocking AEP imparted regulatory function in Tbet+iTreg cells. Also, Aep−/− iTreg cells significantly inhibited GvHD and maintained Foxp3 expression. PD-1-mediated Foxp3 maintenance in Tbet+ Th1 cells occurred both in tumor infiltrating lymphocytes (TILs) and during chronic viral infection. Collectively, this report has identified an intrinsic function for PD-1 in maintaining Foxp3 through proteolytic pathway.Bio-organic Synthesi
COMAP Early Science: III. CO Data Processing
We describe the first season COMAP analysis pipeline that converts raw
detector readouts to calibrated sky maps. This pipeline implements four main
steps: gain calibration, filtering, data selection, and map-making. Absolute
gain calibration relies on a combination of instrumental and astrophysical
sources, while relative gain calibration exploits real-time total-power
variations. High efficiency filtering is achieved through spectroscopic
common-mode rejection within and across receivers, resulting in nearly
uncorrelated white noise within single-frequency channels. Consequently,
near-optimal but biased maps are produced by binning the filtered time stream
into pixelized maps; the corresponding signal bias transfer function is
estimated through simulations. Data selection is performed automatically
through a series of goodness-of-fit statistics, including and
multi-scale correlation tests. Applying this pipeline to the first-season COMAP
data, we produce a dataset with very low levels of correlated noise. We find
that one of our two scanning strategies (the Lissajous type) is sensitive to
residual instrumental systematics. As a result, we no longer use this type of
scan and exclude data taken this way from our Season 1 power spectrum
estimates. We perform a careful analysis of our data processing and observing
efficiencies and take account of planned improvements to estimate our future
performance. Power spectrum results derived from the first-season COMAP maps
are presented and discussed in companion papers.Comment: Paper 3 of 7 in series. 26 pages, 23 figures, submitted to Ap
COMAP Early Science: VII. Prospects for CO Intensity Mapping at Reionization
We introduce COMAP-EoR, the next generation of the Carbon Monoxide Mapping
Array Project aimed at extending CO intensity mapping to the Epoch of
Reionization. COMAP-EoR supplements the existing 30 GHz COMAP Pathfinder with
two additional 30 GHz instruments and a new 16 GHz receiver. This combination
of frequencies will be able to simultaneously map CO(1--0) and CO(2--1) at
reionization redshifts () in addition to providing a significant
boost to the sensitivity of the Pathfinder. We examine a set of
existing models of the EoR CO signal, and find power spectra spanning several
orders of magnitude, highlighting our extreme ignorance about this period of
cosmic history and the value of the COMAP-EoR measurement. We carry out the
most detailed forecast to date of an intensity mapping cross-correlation, and
find that five out of the six models we consider yield signal to noise ratios
(S/N) for COMAP-EoR, with the brightest reaching a S/N above 400.
We show that, for these models, COMAP-EoR can make a detailed measurement of
the cosmic molecular gas history from , as well as probe the
population of faint, star-forming galaxies predicted by these models to be
undetectable by traditional surveys. We show that, for the single model that
does not predict numerous faint emitters, a COMAP-EoR-type measurement is
required to rule out their existence. We briefly explore prospects for a
third-generation Expanded Reionization Array (COMAP-ERA) capable of detecting
the faintest models and characterizing the brightest signals in extreme detail.Comment: Paper 7 of 7 in series. 19 pages, 10 figures, to be submitted to Ap
COMAP Early Science: VI. A First Look at the COMAP Galactic Plane Survey
We present early results from the COMAP Galactic Plane Survey conducted
between June 2019 and April 2021, spanning in Galactic
longitude and |b|<1.\!\!^{\circ}5 in Galactic latitude with an angular
resolution of . The full survey will span -
and will be the first large-scale radio continuum survey at
GHz with sub-degree resolution. We present initial results from the first part
of the survey, including diffuse emission and spectral energy distributions
(SEDs) of HII regions and supernova remnants. Using low and high frequency
surveys to constrain free-free and thermal dust emission contributions, we find
evidence of excess flux density at GHz in six regions that we interpret
as anomalous microwave emission. Furthermore we model UCHII contributions using
data from the GHz CORNISH catalogue and reject this as the cause of the
GHz excess. Six known supernova remnants (SNR) are detected at GHz,
and we measure spectral indices consistent with the literature or show evidence
of steepening. The flux density of the SNR W44 at GHz is consistent with
a power-law extrapolation from lower frequencies with no indication of spectral
steepening in contrast with recent results from the Sardinia Radio Telescope.
We also extract five hydrogen radio recombination lines to map the warm ionized
gas, which can be used to estimate electron temperatures or to constrain
continuum free-free emission. The full COMAP Galactic plane survey, to be
released in 2023/2024, will be an invaluable resource for Galactic
astrophysics.Comment: Paper 6 of 7 in series. 28 pages, 10 figures, submitted to Ap
COMAP Early Science: IV. Power Spectrum Methodology and Results
We present the power spectrum methodology used for the first-season COMAP
analysis, and assess the quality of the current data set. The main results are
derived through the Feed-feed Pseudo-Cross-Spectrum (FPXS) method, which is a
robust estimator with respect to both noise modeling errors and experimental
systematics. We use effective transfer functions to take into account the
effects of instrumental beam smoothing and various filter operations applied
during the low-level data processing. The power spectra estimated in this way
have allowed us to identify a systematic error associated with one of our two
scanning strategies, believed to be due to residual ground or atmospheric
contamination. We omit these data from our analysis and no longer use this
scanning technique for observations. We present the power spectra from our
first season of observing and demonstrate that the uncertainties are
integrating as expected for uncorrelated noise, with any residual systematics
suppressed to a level below the noise. Using the FPXS method, and combining
data on scales we estimate , the first direct 3D
constraint on the clustering component of the CO(1-0) power spectrum in the
literature.Comment: Paper 4 of 7 in series. 18 pages, 11 figures, as accepted in Ap
A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery.
BACKGROUND: Surgical intervention is needed in some cases of spontaneous abortion to remove retained products of conception. Antibiotic prophylaxis may reduce the risk of pelvic infection, which is an important complication of this surgery, particularly in low-resource countries. METHODS: We conducted a double-blind, placebo-controlled, randomized trial investigating whether antibiotic prophylaxis before surgery to complete a spontaneous abortion would reduce pelvic infection among women and adolescents in low-resource countries. We randomly assigned patients to a single preoperative dose of 400 mg of oral doxycycline and 400 mg of oral metronidazole or identical placebos. The primary outcome was pelvic infection within 14 days after surgery. Pelvic infection was defined by the presence of two or more of four clinical features (purulent vaginal discharge, pyrexia, uterine tenderness, and leukocytosis) or by the presence of one of these features and the clinically identified need to administer antibiotics. The definition of pelvic infection was changed before the unblinding of the data; the original strict definition was two or more of the clinical features, without reference to the administration of antibiotics. RESULTS: We enrolled 3412 patients in Malawi, Pakistan, Tanzania, and Uganda. A total of 1705 patients were assigned to receive antibiotics and 1707 to receive placebo. The risk of pelvic infection was 4.1% (68 of 1676 pregnancies) in the antibiotics group and 5.3% (90 of 1684 pregnancies) in the placebo group (risk ratio, 0.77; 95% confidence interval [CI], 0.56 to 1.04; P = 0.09). Pelvic infection according to original strict criteria was diagnosed in 1.5% (26 of 1700 pregnancies) and 2.6% (44 of 1704 pregnancies), respectively (risk ratio, 0.60; 95% CI, 0.37 to 0.96). There were no significant between-group differences in adverse events. CONCLUSIONS: Antibiotic prophylaxis before miscarriage surgery did not result in a significantly lower risk of pelvic infection, as defined by pragmatic broad criteria, than placebo. (Funded by the Medical Research Council and others; AIMS Current Controlled Trials number, ISRCTN97143849.)
COMAP Early Science: V. Constraints and Forecasts at
We present the current state of models for the carbon monoxide (CO)
line-intensity signal targeted by the CO Mapping Array Project (COMAP)
Pathfinder in the context of its early science results. Our fiducial model,
relating dark matter halo properties to CO luminosities, informs parameter
priors with empirical models of the galaxy-halo connection and previous CO(1-0)
observations. The Pathfinder early science data spanning wavenumbers
-Mpc represent the first direct 3D constraint on the
clustering component of the CO(1-0) power spectrum. Our 95% upper limit on the
redshift-space clustering amplitude K greatly
improves on the indirect upper limit of K reported from the CO
Power Spectrum Survey (COPSS) measurement at Mpc. The COMAP
limit excludes a subset of models from previous literature, and constrains
interpretation of the COPSS results, demonstrating the complementary nature of
COMAP and interferometric CO surveys. Using line bias expectations from our
priors, we also constrain the squared mean line intensity-bias product,
K, and the cosmic molecular gas
density, Mpc (95% upper
limits). Based on early instrument performance and our current CO signal
estimates, we forecast that the five-year Pathfinder campaign will detect the
CO power spectrum with overall signal-to-noise of 9-17. Between then and now,
we also expect to detect the CO-galaxy cross-spectrum using overlapping galaxy
survey data, enabling enhanced inferences of cosmic star-formation and
galaxy-evolution history.Comment: Paper 5 of 7 in series. 17 pages + appendix and bibliography (30
pages total); 15 figures, 6 tables; accepted for publication in ApJ; v3
reflects the accepted version with minor changes and additions to tex
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