Generalized hydrodynamics of classical integrable field theory: the sinh-Gordon model

Using generalized hydrodynamics (GHD), we develop the Euler hydrodynamics of classical integrable field theory. Classical field GHD is based on a known formalism for Gibbs ensembles of classical fields, that resembles the thermodynamic Bethe ansatz of quantum models, which we extend to generalized Gibbs ensembles (GGEs). In general, GHD must take into account both solitonic and radiative modes of classical fields. We observe that the quasi-particle formulation of GHD remains valid for radiative modes, even though these do not display particle-like properties in their precise dynamics. We point out that because of a UV catastrophe similar to that of black body radiation, radiative modes suffer from divergences that restrict the set of finite-average observables; this set is larger for GGEs with higher conserved charges. We concentrate on the sinh-Gordon model, which only has radiative modes, and study transport in the domain-wall initial problem as well as Euler-scale correlations in GGEs. We confirm a variety of exact GHD predictions, including those coming from hydrodynamic projection theory, by comparing with Metropolis numerical evaluations.Comment: 41 pages, 9 figure

Changes in the near edge X-ray absorption fine structure of hybrid organic-inorganic resists upon exposure

We report on the near edge X-ray absorption fine structure (NEXAFS) spectroscopy of hybrid organic-inorganic resists. These materials are nonchemically amplified systems based on Si, Zr, and Ti oxides, synthesized from organically modified precursors and transition metal alkoxides by a sol-gel route and designed for ultraviolet, extreme ultraviolet and electron beam lithography. The experiments were conducted using a scanning transmission X-ray microscope (STXM) which combines high spatial-resolution microscopy and NEXAFS spectroscopy. The absorption spectra were collected in the proximity of the carbon edge (~ 290 eV) before and after in situ exposure, enabling the measurement of a significant photo-induced degradation of the organic group (phenyl or methyl methacrylate, respectively), the degree of which depends on the configuration of the ligand. Photo-induced degradation was more efficient in the resist synthesized with pendant phenyl substituents than it was in the case of systems based on bridging phenyl groups. The degradation of the methyl methacrylate group was relatively efficient, with about half of the initial ligands dissociated upon exposure. Our data reveal that the such dissociation can produce different outcomes, depending on the structural configuration. While all the organic groups were expected to detach and desorb from the resist in their entirety, a sizeable amount of them remain and form undesired byproducts such as alkene chains. In the framework of the materials synthesis and engineering through specific building blocks, these results provide a deeper insight into the photochemistry of resists, in particular for extreme ultraviolet lithography

Neutron star glitches have a substantial minimum size

Glitches are sudden spin-up events that punctuate the steady spin down of pulsars and are thought to be due to the presence of a superfluid component within neutron stars. The precise glitch mechanism and its trigger, however, remain unknown. The size of glitches is a key diagnostic for models of the underlying physics. While the largest glitches have long been taken into account by theoretical models, it has always been assumed that the minimum size lay below the detectability limit of the measurements. In this paper we define general glitch detectability limits and use them on 29 years of daily observations of the Crab pulsar, carried out at Jodrell Bank Observatory. We find that all glitches lie well above the detectability limits and by using an automated method to search for small events we are able to uncover the full glitch size distribution, with no biases. Contrary to the prediction of most models, the distribution presents a rapid decrease of the number of glitches below ~0.05 $\mu$Hz. This substantial minimum size indicates that a glitch must involve the motion of at least several billion superfluid vortices and provides an extra observable which can greatly help the identification of the trigger mechanism. Our study also shows that glitches are clearly separated from all the other rotation irregularities. This supports the idea that the origin of glitches is different to that of timing noise, which comprises the unmodelled random fluctuations in the rotation rates of pulsars.Comment: 8 pages; 4 figures. Accepted for publication in MNRA

A High Speed Hardware Scheduler for 1000-port Optical Packet Switches to Enable Scalable Data Centers

Meeting the exponential increase in the global demand for bandwidth has become a major concern for today's data centers. The scalability of any data center is defined by the maximum capacity and port count of the switching devices it employs, limited by total pin bandwidth on current electronic switch ASICs. Optical switches can provide higher capacity and port counts, and hence, can be used to transform data center scalability. We have recently demonstrated a 1000-port star-coupler based wavelength division multiplexed (WDM) and time division multiplexed (TDM) optical switch architecture offering a bandwidth of 32 Tbit/s with the use of fast wavelength-tunable transmitters and high-sensitivity coherent receivers. However, the major challenge in deploying such an optical switch to replace current electronic switches lies in designing and implementing a scalable scheduler capable of operating on packet timescales. In this paper, we present a pipelined and highly parallel electronic scheduler that configures the high-radix (1000-port) optical packet switch. The scheduler can process requests from 1000 nodes and allocate timeslots across 320 wavelength channels and 4000 wavelength-tunable transceivers within a time constraint of 1μs. Using the Opencell NanGate 45nm standard cell library, we show that the complete 1000-port parallel scheduler algorithm occupies a circuit area of 52.7mm2, 4-8x smaller than that of a high-performance switch ASIC, with a clock period of less than 8ns, enabling 138 scheduling iterations to be performed in 1μs. The performance of the scheduling algorithm is evaluated in comparison to maximal matching from graph theory and conventional software-based wavelength allocation heuristics. The parallel hardware scheduler is shown to achieve similar matching performance and network throughput while being orders of magnitude faster

The Study of mpValCitGlyPro Linker for Alcohol Payload Release

Antibody-drug-conjugates (ADCs) are a class of drugs that deliver potent payloads to specific cells or tissues via cell-specific uptake. ADCs are composed of an antibody that is specific to the intended target which is tethered to a payload by a cleavable linker. They are unique because they have the ability to deliver extremely cytotoxic payloads to only certain areas of the body without harming non-targeted tissues. There are currently ten ADCs that are FDA approved, most of which release amine-containing payloads. There is very limited technology that is effective for releasing alcohol-containing payloads. We have designed a tetrapeptide linker referred to as ”ValCitGlyPro” that has shown success when compared to a simple ester linker (“mc”). We demonstrate that the mc linker is not readily cleaved by lysosomes, while the ValCitGlyPro linker is. Further, we demonstrate that this linker has modest stability in mouse and human serum. Finally, we have evaluated various breast-cancer-targeting ADCs with both the mpValCitGlyPro and the mc linker and have measured the intracellular payload concentration in a breast cancer cell line. Together, this data is being used to evaluate whether the ValCitGlyPro linker system is a suitable technology for the delivery of alcohol-containing payloads.https://orb.binghamton.edu/research_days_posters_2021/1050/thumbnail.jp

Online prostate cancer screening decision aid for at-risk men: A randomized trial

Objective: This study examines the efficacy of an online decision aid (DA) for men with a family history of prostate cancer. Methods: Unaffected Australian men (40 - 79 years) with at least one affected relative completed the first online questionnaire, were randomized to read either the tailored DA (intervention) or nontailored information about prostate cancer screening (control), then completed a questionnaire postreading and 12 months later. The primary outcome was decisional conflict regarding prostate specific antigen (PSA) testing. The impact of the DA on longitudinal outcomes was analyzed by using random intercept mixed effects models. Logistic and linear regressions were used to analyze the impact of the DA on screening behavior and decision regret. Stage of decision-making was tested as a moderator for decisional conflict and decision regret. The frequency of online material access was recorded. Results: the DA had no effect on decisional conflict, knowledge, inclination toward PSA testing, accuracy of perceived risk, or screening behavior. However, among men considering PSA testing, those who read the DA had lower decision regret compared with men who read the control materials, β=.34 , p \u3c.001, 95% confidence interval (CI) = [.22, .53]. Conclusions: This is the first study to our knowledge to evaluate the uptake and efficacy of an online screening DA among men with a family history of prostate cancer. Men who were undecided about screening at baseline benefitted from the DA, experiencing less regret 12 months later. In relation to decisional conflict, the control materials may have operated as a less complex and equally informative DA

Densification of polymer glass film under combined high pressure and shear flow revealed via scanning X-ray microscopy

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Nanoscale X-ray investigation of magnetic metallofullerene peapods

Endohedral lanthanide ions packed inside carbon nanotubes (CNTs) in a one-dimensional assembly have been studied with a combination of high resolution transmission electron microscopy (HRTEM), scanning transmission X-ray microscopy (STXM), and X-ray magnetic circular dichroism (XMCD). By correlating HRTEM and STXM images we show that structures down to 30 nm are resolved with chemical contrast and record X-ray absorption spectra from endohedral lanthanide ions embedded in individual nanoscale CNT bundles. XMCD measurements of an Er$_3$N@C$_{80}$ bulk sample and a macroscopic assembly of filled CNTs indicates that the magnetic properties of the endohedral Er3+ ions are unchanged when encapsulated in CNTs. This study demonstrates the feasibility of local magnetic X-ray characterization of low concentrations of lanthanide ions embedded in molecular nanostructures