Journeys to Everest and Vanishing Glaciers

Take a journey into the Everest region of Nepal. This book tells the story of a dynamic landscape shaped by glaciers, inhabited by people and wildlife, and visited by tens of thousands of tourists each year. The landscape, flora, and fauna, are illustrated using photographs taken throughout Sagarmatha National Park and we present the current state of scientific understanding on the park’s thinning glaciers

Observing the CMB at High-l using the VSA and AMI

We discuss two experiments - the Very Small Array (VSA) and the Arcminute MicroKelvin Imager (AMI) - and their prospects for observing the CMB at high angular multipoles. Whilst the VSA is primarily designed to observe primary anisotropies in the CMB, AMI is designed to image secondary anisotropies via the Sunyaev-Zel'dovich effect. The combined l-range of these two instruments is between l = 150 and ~10000.Comment: 8 pages, 13 figures. To be published in the proceedings of "The Cosmic Microwave Background and its Polarization", New Astronomy Reviews, (eds. S. Hanany and K.A. Olive

Linear Perturbations in Brane Gas Cosmology

We consider the effect of string inhomogeneities on the time dependent background of Brane Gas Cosmology. We derive the equations governing the linear perturbations of the dilaton-gravity background in the presence of string matter sources. We focus on long wavelength fluctuations and find that there are no instabilities. Thus, the predictions of Brane Gas Cosmology are robust against the introduction of linear perturbations. In particular, we find that the stabilization of the extra dimensions (moduli) remains valid in the presence of dilaton and string perturbations.Comment: 17 pages, 1 figur

A 6-12 GHz Analogue Lag-Correlator for Radio Interferometry

Aims: We describe a 6-12 GHz analogue correlator that has been developed for use in radio interferometers. Methods: We use a lag-correlator technique to synthesis eight complex spectral channels. Two schemes were considered for sampling the cross-correlation function, using either real or complex correlations, and we developed prototypes for both of them. We opted for the ``add and square'' detection scheme using Schottky diodes over the more commonly used active multipliers because the stability of the device is less critical. Results: We encountered an unexpected problem, in that there were errors in the lag spacings of up to ten percent of the unit spacing. To overcome this, we developed a calibration method using astronomical sources which corrects the effects of the non-uniform sampling as well as gain error and dispersion in the correlator.Comment: 14 pages, 21 figures, accepted for publication in A&

A 6-12 GHz Analogue Lag-Correlator for Radio Interferometry

Aims: We describe a 6-12 GHz analogue correlator that has been developed for use in radio interferometers. Methods: We use a lag-correlator technique to synthesis eight complex spectral channels. Two schemes were considered for sampling the cross-correlation function, using either real or complex correlations, and we developed prototypes for both of them. We opted for the ``add and square'' detection scheme using Schottky diodes over the more commonly used active multipliers because the stability of the device is less critical. Results: We encountered an unexpected problem, in that there were errors in the lag spacings of up to ten percent of the unit spacing. To overcome this, we developed a calibration method using astronomical sources which corrects the effects of the non-uniform sampling as well as gain error and dispersion in the correlator.Comment: 14 pages, 21 figures, accepted for publication in A&

A systematic review and narrative synthesis of pharmacist-led education-based antimicrobial stewardship interventions and their effect on antimicrobial use in hospital inpatients

Acknowledgements The authors would like to thank Dr Peerawat Jinathongthai and Dr Sisira Donsamak (Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Thailand) who advised and contributed in the literature search. Funding TM has received the Royal Thai Government Scholarship for his doctoral study (scholarship number ST G5397) at The University of Bath, Bath, UK. None of the other authors were funded by a specific grant for this research from any funding agency in the public, commercial, or non-for-profit sectors.Peer reviewedPostprin

Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss

The association between hypoalbuminemia and poor prognosis in patients with cancer is well recognized. However, the factors that contribute to the fall in albumin concentrations are not well understood. In the present study, we examined the relationship between circulating albumin concentrations, weight loss, the body cell mass (measured using total body potassium), and the presence of an inflammatory response (measured using C- reactive protein) in male patients (n=40) with advanced lung or gastrointestinal cancer. Albumin concentrations were significantly correlated with the percent ideal body weight (r=0.390, p lt 0.05), extent of reported weight loss (r=-0.492, p lt 0.01), percent predicted total body potassium (adjusted for age, height, and weight, r=0.686, p lt 0.001), and logo C-reactive protein concentrations (r=-0.545, p lt 0.001). On multiple regression analysis, the percent predicted total body potassium and log(10) C-reactive protein concentrations accounted for 63% of the variation in albumin concentrations (r(2) = 0.626, p lt 0.001). The interrelationship between albumin, body cell mass, and the inflammatory response is consistent with the concept that the presence of an ongoing inflammatory response contributes to the progressive loss of these vital protein components of the body and the subsequent death of patients with advanced cancer

A Mean-Field Theory for Coarsening Faceted Surfaces

A mean-field theory is developed for the scale-invariant length distributions observed during the coarsening of one-dimensional faceted surfaces. This theory closely follows the Lifshitz-Slyozov-Wagner theory of Ostwald ripening in two-phase systems [1-3], but the mechanism of coarsening in faceted surfaces requires the addition of convolution terms recalling the work of Smoluchowski [4] and Schumann [5] on coalescence. The model is solved by the exponential distribution, but agreement with experiment is limited by the assumption that neighboring facet lengths are uncorrelated. However, the method concisely describes the essential processes operating in the scaling state, illuminates a clear path for future refinement, and offers a framework for the investigation of faceted surfaces evolving under arbitrary dynamics. [1] I. Lifshitz, V. Slezov, Soviet Physics JETP 38 (1959) 331-339. [2] I. Lifshitz, V. Slyozov, J. Phys. Chem. Solids 19 (1961) 35-50. [3] C. Wagner, Elektrochemie 65 (1961) 581-591. [4] M. von Smoluchowski, Physikalische Zeitschrift 17 (1916) 557-571. [5] T. Schumann, J. Roy. Met. Soc. 66 (1940) 195-207

A new method for imaging nuclear threats using cosmic ray muons

Muon tomography is a technique that uses cosmic ray muons to generate three dimensional images of volumes using information contained in the Coulomb scattering of the muons. Advantages of this technique are the ability of cosmic rays to penetrate significant overburden and the absence of any additional dose delivered to subjects under study above the natural cosmic ray flux. Disadvantages include the relatively long exposure times and poor position resolution and complex algorithms needed for reconstruction. Here we demonstrate a new method for obtaining improved position resolution and statistical precision for objects with spherical symmetry