South Wales

Carboniferous rocks in this region occur in a broadly east-west trending syncline, the core of which includes the South Wales and Pembrokeshire coalfields (Fig. 5.1). Tournaisian and Visean strata (Avon and Pembroke Limestone groups) represent deposition on a southward prograding carbonate ramp evolving into a carbonate shelf (Wright 1987), in a succession which shows similarities to that of the Bristol and Mendips areas (Chapter 6). The main outcrops, in south Pembrokeshire, Gower and the Vale of Glamorgan, occur along the southern periphery of the coalfields and are commonly affected by Variscan thrusting and folding. Thinner successions occur along what is termed the East Crop and North Crop of the South Wales Coalfield, where much of the Visean succession is absent due to sub-Namurian and intra-Visean unconformities. Namurian fluvio-deltaic deposits (Marros Group) flank the South Wales and Pembrokeshire coalfields. Much of the lower and middle Namurian succession is absent across the region, except in the west of the South Wales Coalfield where only small parts are absent beneath an intra-Namurian unconformity. Westphalian fluvio-lacustrine deposits (South Wales Coal Measures Group) form the South Wales and Pembrokeshire coalfields, located to the east and west of Carmarthen Bay, respectively. Westphalian to Stephanian Pennant alluvial facies (Warwickshire Group) occur in the core of the South Wales Coalfield syncline. Deposition of the South Wales Coal Measures and Warwickshire groups was probably laterally contiguous with those in the Bristol and Somerset coalfields (Chapter 6), but the Usk-Cowbridge High controlled and restricted sedimentation for much of the Carboniferous, with pre-Namurian uplift and erosion removing the Tournaisian and Visean succession. Later uplift is also believed to have caused attenuation of the Warwickshire Group in the east of the South Wales Coalfield. The lithostratigraphical nomenclature for the region is that of Waters et al. (2007; 2009)

Lithostratigraphy of the Old Red Sandstone successions of the Anglo-Welsh Basin

This report presents a revised lithostratigraphy of the Old Red Sandstone of the Anglo-Welsh Basin, prepared under the auspices of the British Geological Survey (BGS) Stratigraphical Framework Committee (SFC). The report provides a correlation of the successions in different parts of the basin and rationalises group and formation nomenclature for the outcrops of Old Red Sandstone in England and Wales. It is based on a previous discussion document (Barclay, unpublished MS, 2007) which presented options in a three-step approach towards rationalisation to a proposed single, standard scheme that can be applied to most of the Pridoli–Lochkovian succession (lower part of the Lower Old Red Sandstone) of the Anglo-Welsh Basin. The earlier discussion document was circulated among geologists with expertise in the Old Red Sandstone of the Anglo-Welsh Basin in and outside the British Geological Survey. This version takes account of the suggestions for improvement and comments made during the consultation process. One significant change from previous classifications concerns the base of the Old Red Sandstone. There is a consensus that this should be placed at the base of the first major incoming of red- or green-bed (‘Old Red Sandstone’) terrestrial facies, thereby excluding the shallow marine Downton Castle Sandstone and Tilestones formations that have traditionally been included in the Old Red Sandstone. The report proposes the introduction of two new names and group status for the successions traditionally referred to as the Lower Old Red Sandstone and Upper Old Red Sandstone. The two successions are separated by the major, regional, cleavage-forming Acadian unconformity, and because of this, the authors have made a case for giving them supergroup status. However, they are here accorded group status in accordance with practice in the other Old Red Sandstone basins of the United Kingdom, both onshore and offshore. In nationwide standardisation, all the groups are informally referred to the as-yet undefined parent ‘Old Red Sandstone Supergroup’, although the authors propose that the term ‘Old Red Sandstone’ is best retained as a facies (or magnafacies) term. The Lower Old Red Sandstone is termed the Daugleddau Group and the Upper Old Red Sandstone is termed the Brecon Beacons Group

Identifying and explaining the variability in development and implementation costs of disease management programs in the Netherlands

BACKGROUND: In the Netherlands, disease management programs (DMPs) are used to treat chronic diseases. Their aim is to improve care and to control the rising expenditures related to chronic diseases. A bundled payment was introduced to facilitate the implementation of DMPs. This payment is an all-inclusive price per patient per year for a pre-specified care package. However, it is unclear to which extent the costs of developing and implementing DMPs are included in this price. Consequently, the organizations providing DMPs bear financial risk because the development and implementation (D&I) costs may be substantial. The aim of this paper is to investigate the variability in and drivers of D&I costs among 22 DMPs and highlight characteristics th

Prevention of childhood poisoning in the home: overview of systematic reviews and a systematic review of primary studies

Unintentional poisoning is a significant child public health problem. This systematic overview of reviews, supplemented with a systematic review of recently published primary studies synthesizes evidence on non-legislative interventions to reduce childhood poisonings in the home with particular reference to interventions that could be implemented by Children's Centres in England or community health or social care services in other high income countries. Thirteen systematic reviews, two meta-analyses and 47 primary studies were identified. The interventions most commonly comprised education, provision of cupboard/drawer locks, and poison control centre (PCC) number stickers. Meta-analyses and primary studies provided evidence that interventions improved poison prevention practices. Twenty eight per cent of studies reporting safe medicine storage (OR from meta-analysis 1.57, 95% CI 1.22–2.02), 23% reporting safe storage of other products (OR from meta-analysis 1.63, 95% CI 1.22–2.17) and 46% reporting availability of PCC numbers (OR from meta-analysis 3.67, 95% CI 1.84–7.33) demonstrated significant effects favouring the intervention group. There was a lack of evidence that interventions reduced poisoning rates. Parents should be provided with poison prevention education, cupboard/drawer locks and emergency contact numbers to use in the event of a poisoning. Further research is required to determine whether improving poison prevention practices reduces poisoning rates

A New Faint Milky Way Satellite Discovered in the Pan-STARRS1 3π Survey

We present the discovery of a faint Milky Way satellite, Laevens 2/Triangulum II, found in the Panoramic Survey Telescope And Rapid Response System (Pan-STARRS 1) 3 pi imaging data and confirmed with follow-up wide-field photometry from the Large Binocular Cameras. The stellar system, with an absolute magnitude of M_V=-1.8 +/-0.5, a heliocentric distance of 30 +2/-2 kpc, and a half-mass radius of 34 +9/-8 pc, shows remarkable similarity to faint, nearby, small satellites such as Willman 1, Segue 1, Segue 2, and Bo\"otes II. The discovery of Laevens 2/Triangulum II further populates the region of parameter space for which the boundary between dwarf galaxies and globular clusters becomes tenuous. Follow-up spectroscopy will ultimately determine the nature of this new satellite, whose spatial location hints at a possible connection with the complex Triangulum-Andromeda stellar structures

Low-mass pre--main-sequence stars in the Magellanic Clouds

[Abridged] The stellar Initial Mass Function (IMF) suggests that sub-solar stars form in very large numbers. Most attractive places for catching low-mass star formation in the act are young stellar clusters and associations, still (half-)embedded in star-forming regions. The low-mass stars in such regions are still in their pre--main-sequence (PMS) evolutionary phase. The peculiar nature of these objects and the contamination of their samples by the evolved populations of the Galactic disk impose demanding observational techniques for the detection of complete numbers of PMS stars in the Milky Way. The Magellanic Clouds, the companion galaxies to our own, demonstrate an exceptional star formation activity. The low extinction and stellar field contamination in star-forming regions of these galaxies imply a more efficient detection of low-mass PMS stars than in the Milky Way, but their distance from us make the application of special detection techniques unfeasible. Nonetheless, imaging with the Hubble Space Telescope yield the discovery of solar and sub-solar PMS stars in the Magellanic Clouds from photometry alone. Unprecedented numbers of such objects are identified as the low-mass stellar content of their star-forming regions, changing completely our picture of young stellar systems outside the Milky Way, and extending the extragalactic stellar IMF below the persisting threshold of a few solar masses. This review presents the recent developments in the investigation of PMS stars in the Magellanic Clouds, with special focus on the limitations by single-epoch photometry that can only be circumvented by the detailed study of the observable behavior of these stars in the color-magnitude diagram. The achieved characterization of the low-mass PMS stars in the Magellanic Clouds allowed thus a more comprehensive understanding of the star formation process in our neighboring galaxies.Comment: Review paper, 26 pages (in LaTeX style for Springer journals), 4 figures. Accepted for publication in Space Science Review

Prospects for Studies of Stellar Evolution and Stellar Death in the JWST Era

I review the prospects for studies of the advanced evolutionary stages of low-, intermediate- and high-mass stars by the JWST and concurrent facilities, with particular emphasis on how they may help elucidate the dominant contributors to the interstellar dust component of galaxies. Observations extending from the mid-infrared to the submillimeter can help quantify the heavy element and dust species inputs to galaxies from AGB stars. JWST's MIRI mid-infrared instrument will be so sensitive that observations of the dust emission from individual intergalactic AGB stars and planetary nebulae in the Virgo Cluster will be feasible. The Herschel Space Observatory will enable the last largely unexplored spectral region, the far-IR to the submillimeter, to be surveyed for new lines and dust features, while SOFIA will cover the wavelength gap between JWST and Herschel, a spectral region containing important fine structure lines, together with key water-ice and crystalline silicate bands. Spitzer has significantly increased the number of Type II supernovae that have been surveyed for early-epoch dust formation but reliable quantification of the dust contributions from massive star supernovae of Type II, Type Ib and Type Ic to low- and high-redshift galaxies should come from JWST MIRI observations, which will be able to probe a volume over 1000 times larger than Spitzer.Comment: 24 pages, 19 figures. To appear in `Astrophysics in the Next Decade: JWST and Concurrent Facilities' (JWST Conference Proceedings), edited by H. A. Thronson, M. Stiavelli and A. G. G. M. Tielens; Springer Series: Astrophysics and Space Science Proceeding

Renal safety of tenofovir alafenamide vs. tenofovir disoproxil fumarate: A pooled analysis of 26 clinical trials

Objective:Compared with tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF) has been associated with improvement in markers of renal dysfunction in individual randomized trials; however, the comparative incidence of clinically significant renal events remains unclear.Design:We used a pooled data approach to increase the person-years of drug exposure analysed, maximizing our ability to detect differences in clinically significant outcomes.Methods:We pooled clinical renal safety data across 26 treatment-naive and antiretroviral switch studies to compare the incidence of proximal renal tubulopathy and discontinuation due to renal adverse events between participants taking TAF-containing regimens vs. those taking TDF-containing regimens. We performed secondary analyses from seven large randomized studies (two treatment-naive and five switch studies) to compare incidence of renal adverse events, treatment-emergent proteinuria, changes in serum creatinine, creatinine clearance, and urinary biomarkers (albumin, beta-2-microglobulin, and retinol binding protein-to-creatinine ratios).Results:Our integrated analysis included 9322 adults and children with HIV (n = 6360 TAF, n = 2962 TDF) with exposure of 12 519 person-years to TAF and 5947 to TDF. There were no cases of proximal renal tubulopathy in participants receiving TAF vs. 10 cases in those receiving TDF (P < 0.001), and fewer individuals on TAF (3/6360) vs. TDF (14/2962) (P < 0.001) discontinued due to a renal adverse event. Participants initiating TAF-based vs. TDF-based regimens had more favourable changes in renal biomarkers through 96 weeks of therapy.Conclusion:These pooled data from 26 studies, with over 12 500 person-years of follow-up in children and adults, support the comparative renal safety of TAF over TDF