Development of a Wöhler-like approach to quantify the Ti(CxNy) coatings durability under oscillating sliding conditions

The selection of a proper material for the particular engineering application is a complex problem, as different materials offer unique properties and it is not possible to gather all useful characteristics in a single one. Hence, employment of different surface treatment processes is a widely used alternative solution. In many industrial applications, coating failure may be conducive to catastrophic consequences. Thus, to prevent the component damage it is essential to establish the coating endurance and indicate the safe running time of coated system. To this study PVD TiC, TiN and TiCN hard coatings have been selected and tested against polycrystalline alumina smooth ball. The series of fretting tests with reciprocating sliding at the frequency 5Hz have been carried out under 50-150N normal loads and under wide rage of constant as well as variable displacement amplitudes from 50µm to 200µm at a constant value of relative humidity of 50% at 296K temperature. To quantify the loss of material a dissipated energy approach has been applied where the wear depth evolution is referred to the cumulative density of friction work dissipated during the test. Different dominant damage mechanisms have been indicated for the investigated hard coatings, which is debris formation and ejection in case of TiC coating and progressive wear accelerated by cracking phenomena in case of TiN and TiCN coatings. Energy-Wöhler wear chart has been introduced, in which the critical 1 dissipated energy density corresponds to the moment when the substrate is reached after a given number of fretting cycles. Two different methods to determine the critical dissipated energy density are introduced and compared. The Energy-Wöhler approach has been employed not only to compare the global endurance of the investigated systems but also to compare the intrinsic wear properties of the coatings. It has been shown that the fretting wear process is accelerated by the stress-controlled spalling phenomenon below a critical residual thickness and a severe decohesion mechanism is activated. Finally the applicability of the investigated method to other coated systems subjected to wear under sliding conditions is discussed and analyzed. The perspectives of this new approach are elucidated

Therapeutic and Mechanistic Perspectives of Protein Complexes in Breast Cancer.

Breast cancer affects one in eight women making it the most common cancer in the United Kingdom, accounting for 15% of all new cancer cases. One of the main challenges in treating breast cancer is the heterogeneous nature of the disease. At present, targeted therapies are available for hormone receptor- and HER2-positive tumors. However, no targeted therapies are currently available for patients with triple negative breast cancer (TNBC). This likely contributes to the poor prognostic outcome for TNBC patients. Consequently, there is a clear clinical need for the development of novel drugs that efficiently target TNBC. Extensive genomic and transcriptomic characterization of TNBC has in recent years identified a plethora of putative oncogenes. However, these driver oncogenes are often critical in other cell types and/or transcription factors making them very difficult to target directly. Therefore, other approaches may be required for developing novel therapeutics that fully exploit the specific functions of TNBC oncogenes in tumor cells. Here, we will argue that more research is needed to identify the protein-protein interactions of TNBC oncogenes as a means for (a) mechanistically understanding the biological function of these oncogenes in TNBC and (b) providing novel therapeutic targets that can be exploited for selectively inhibiting the oncogenic roles of TNBC oncogenes in cancer cells, whilst sparing normal healthy cells

Undated - J.T. Waterhouse writes Colonel E.K. Harding

https://digitalmaine.com/cw_me_17th_regiment_corr/1005/thumbnail.jp

Examining the Use of Web-Based Reusable Learning Objects by Animal and Veterinary Nursing Students

This intervention study examined the interaction of animal- and veterinary nursing students with reusable learning objects (RLO) in the context of preparing for summative assessment. Data was collected from 199 undergraduates using quantitative and qualitative methods. Students accessed RLO via personal devices in order to reinforce taught sessions. Interviewees reported that the RLO helped them meet the requirements of the curriculum. Quantitative data supported two valid points; the lack of engagement of students when given a free-choice and reluctance for self-assessment. The practical significance of the qualitative outcomes lies with how first year undergraduates on animal and veterinary nursing-related courses use RLO designed to address equine management and health topics, where the students have mixed equine experience

The Use of Reusable Learning Objects to Enhance the Delivery of Veterinary Education: A Literature Review

The increased demand from learners in higher education to access resources flexibly has resulted in considerable development in the use of Reusable Learning Objects (RLO) via a blended learning format across the sector. This critical review sets out to identify what is currently known about RLO and how those concepts can be applied to veterinary-related degree courses. The review provides an insight into an aspect of blended learning which is currently limited in terms of published research. The effect of computer confidence, students' choice to use and the impact on student performance are some of the variables which have been measured to date. The approach to RLO by students from different courses may vary, but prior experience of technology, alignment of content and availability of technical support are some of the key drivers for usage and reuse. A positive effect is likely to occur following RLO use because those students have adopted a process of active engagement, which the authors know can bring about a deeper approach to learning

The valuation of European financial firms

We extend the recent literature concerning accounting based valuation models to investigate financial firms from six European countries with substantial financial sectors: France, Germany, Italy, Netherlands, Switzerland and the UK. Not only are these crucial industries worthy of study in their own right, but unusual accounting practices, and inter-country differences in those accounting practices, provide valuable insights into the accounting-value relationship. Our sample consists of 7,714 financial firm/years observations from 1,140 companies drawn from 1989-2000. Sub-samples include 1,309 firm/years for banks, 650 for insurance companies, 1,705 for real estate firms, and 3,239 for investment companies. In most countries we find that the valuation models work as well or better in explaining cross-sectional variations in the market-to-book ratio for financial firms as they do for industrial and commercial firms in the same countries, although Switzerland is an exception to this generalization. As expected, the results are sensitive to industrial differences, accounting regulation and accounting practices. In particular, marking assets to market value reduces the relevance of earnings figures and increases that of equity

Spatial Curvature Falsifies Eternal Inflation

Inflation creates large-scale cosmological density perturbations that are characterized by an isotropic, homogeneous, and Gaussian random distribution about a locally flat background. Even in a flat universe, the spatial curvature measured within one Hubble volume receives contributions from long wavelength perturbations, and will not in general be zero. These same perturbations determine the Cosmic Microwave Background (CMB) temperature fluctuations, which are O(10^-5). Consequently, the low-l multipole moments in the CMB temperature map predict the value of the measured spatial curvature \Omega_k. On this basis we argue that a measurement of |\Omega_k| > 10^-4 would rule out slow-roll eternal inflation in our past with high confidence, while a measurement of \Omega_k < -10^-4 (which is positive curvature, a locally closed universe) rules out false-vacuum eternal inflation as well, at the same confidence level. In other words, negative curvature (a locally open universe) is consistent with false-vacuum eternal inflation but not with slow-roll eternal inflation, and positive curvature falsifies both. Near-future experiments will dramatically extend the sensitivity of \Omega_k measurements and constitute a sharp test of these predictions.Comment: 16+2 pages, 2 figure

Two-dimensional photocatalyst design: A critical review of recent experimental and computational advances

In recent years, two-dimensional (2D) semiconductor photocatalysts have been widely applied in water splitting, CO2 reduction, N2 fixation, as well as many other important photoreactions. Photocatalysts in the form of 2D nanosheet possess many inherent advantages over traditional 3D nanopowder photocatalysts, including improved light absorption characteristics, shorter electron and hole migration paths to the photocatalysts’ surface (thus minimizing undesirable electron-hole pair recombination), and abundant surface defects which allow band gap modulation and facilitate charge transfer from the semiconductor to adsorbates. When synergistically exploited and optimized, these advantages can impart 2D photocatalysts with remarkable activities relative to their 3D counterparts. Accordingly, a wide range of experimental approaches is now being explored for the synthesis of 2D photocatalysts, with computational methods increasingly being used for identification of promising new 2D photocatalytic materials. Herein, we critically review recent literatures related to 2D photocatalyst development and design. Particular emphasis is placed on 2D photocatalyst synthesis and the importance of computational studies for the fundamental understanding of 2D photocatalyst electronic structure, band gap structure, charge carrier mobility and reaction pathways. We also explore the practical challenges of using 2D photocatalysts, such as their difficulty to synthesize in large quantity and also their characterization. The overarching aim of this review is to provide a snapshot of recent work targeting high-performance 2D photocatalysts for efficient solar energy conversion, thus laying a firm base for future advancements in this rapidly expanding area of photocatalysis research