速筋における低頻度疲労の発生メカニズム : 筋原線維のCa2+感受性と筋小胞体のCa2+放出機能に着目して

内容の要約広島大学(Hiroshima University)博士(学術)Doctor of Philosophydoctora

Position-controlled trapping of nanoparticles and quantum dots on a fiber taper

We investigate numerically and experimentally the properties of a two color optical fiber taper trap, for which the evanescent field of the modes in the fiber taper give rise to a three-dimensional trapping potential. Experimentally, we use the technique to confine colloidal nanoparticles near the surface of an optical fiber taper, and show that the trapping position of the particles is adjustable by controlling the relative power of two modes in the fiber. We also demonstrate a proof of principle application by trapping quantum dots together with gold nanoparticles in a configuration where the trapping fields double as the excitation field for the quantum dots. This scheme will allow the positioning of quantum emitters in order to adjust coupling to resonators combined with the fiber taper.Comment: 13 pages, 9 figures. Comments welcom

Study of ionospheric disturbances during solar flare events using the SuperDARN Hokkaido radar

It is well known that many types of ionospheric disturbances occur during solar flare events. The sudden increase in total electron content (SITEC) has been studied for several decades, but total electron content (TEC) data do not provide information on the altitudinal distribution of electron density changes. Previous studies used HF Doppler system data to investigate the contributions of the D-region and F-region ionospheric electron density changes by examining the HF radio wave frequency dependence on the Doppler shift values. In this study we examined the dependence of the elevation angle of the Doppler shift of ground scatter echoes using the SuperDARN Hokkaido radar. We analyzed solar flare events from Dec 2006 to Mar 2012. A sudden fade-out of echoes was observed in almost all the events we analyzed, which was the result of the radio absorption associated with a significant increase in electron density within the D-region ionosphere. In addition, we discovered positive Doppler shifts just before the sudden fade-out of echoes. The Doppler shift is negatively correlated with the elevation angle of received radar waves. It indicates that variation of electron density in the D-region ionosphere is dominant during solar flare events. This result is consistent with a previous study. We also compared the irradiation by X-ray and extreme ultra violet rays observed by the GOES-14 and GOES-15 satellites, which generated Doppler shifts. A positive Doppler shift is consistent with a change of X-ray flux

Study of characteristics of ionospheric disturbances during solar flare events with the SuperDARN Hokkaido Radar

第3回極域科学シンポジウム/第36回極域宙空圏シンポジウム 11月26日（月）、27日（火） 国立極地研究所 2階ラウン

Ground-state properties of neutron-rich Mg isotopes

We analyze recently-measured total reaction cross sections for 24-38Mg isotopes incident on 12C targets at 240 MeV/nucleon by using the folding model and antisymmetrized molecular dynamics(AMD). The folding model well reproduces the measured reaction cross sections, when the projectile densities are evaluated by the deformed Woods-Saxon (def-WS) model with AMD deformation. Matter radii of 24-38Mg are then deduced from the measured reaction cross sections by fine-tuning the parameters of the def-WS model. The deduced matter radii are largely enhanced by nuclear deformation. Fully-microscopic AMD calculations with no free parameter well reproduce the deduced matter radii for 24-36Mg, but still considerably underestimate them for 37,38Mg. The large matter radii suggest that 37,38Mg are candidates for deformed halo nucleus. AMD also reproduces other existing measured ground-state properties (spin-parity, total binding energy, and one-neutron separation energy) of Mg isotopes. Neutron-number (N) dependence of deformation parameter is predicted by AMD. Large deformation is seen from 31Mg with N = 19 to a drip-line nucleus 40Mg with N = 28, indicating that both the N = 20 and 28 magicities disappear. N dependence of neutron skin thickness is also predicted by AMD.Comment: 15 pages, 13 figures, to be published in Phys. Rev.

Noticeable Reverse Shift in the Melting Temperatures of Benzene and Carbon Tetrachloride Confined within the Micropores and Mesopores of Hydrophobic Carbons

Carbon aerogels contain both mesopores and micropores. In this study, benzene/CCl4 was adsorbed in the pores of carbon aerogels (both mesopores and micropores) and their phase behaviours were examined using differential scanning calorimetry. The bulk solid benzene melted at 278 K and the melting temperatures of benzene confined inside the mesopores and micropores of carbon aerogels were 258 and 293 K, respectively. Although the melting temperature depression of condensates in mesopores is well known, the observed elevation of the melting temperature for micropores is very limited in the strongly interacted system. Similar melting behaviours were observed for the confined CCl4; depression by 45 K in mesopores and elevation by 48 K in micropores showed about two times the change as compared with that of confined benzene.ArticleADSORPTION SCIENCE & TECHNOLOGY. 31(2-3):145-151 (2013)journal articl

Population Genetic Structure of a Bamboo Taxon, Pleioblastus Sect. Pleioblastus, in the Ryukyu Islands Formed by Geohistory and Human Activity

departmental bulletin pape

The SGLT2 inhibitor empagliflozin improves cardiac energy status via mitochondrial ATP production in diabetic mice

Empagliflozin, a sodium-glucose co-transporter 2 inhibitor developed, has been shown to reduce cardiovascular events in patients with type 2 diabetes and established cardiovascular disease. Several studies have suggested that empagliflozin improves the cardiac energy state which is a partial cause of its potency. However, the detailed mechanism remains unclear. To address this issue, we used a mouse model that enabled direct measurement of cytosolic and mitochondrial ATP levels. Empagliflozin treatment significantly increased cytosolic and mitochondrial ATP levels in the hearts of db/db mice. Empagliflozin also enhanced cardiac robustness by maintaining intracellular ATP levels and the recovery capacity in the infarcted area during ischemic-reperfusion. Our findings suggest that empagliflozin enters cardiac mitochondria and directly causes these effects by increasing mitochondrial ATP via inhibition of NHE1 and Nav1.5 or their common downstream sites. These cardioprotective effects may be involved in the beneficial effects on heart failure seen in clinical trials