6,730 research outputs found
Aquila 1943 (Tri-State High School Yearbook)
https://scholarlycommons.pacific.edu/cook-nisei/1001/thumbnail.jp
Prevention of NSAID-Induced Small Intestinal Mucosal Injury: Prophylactic Potential of Lansoprazole
Non-steroidal anti-inflammatory drugs (NSAIDs), which are used for the treatment of several inflammatory disorders including rheumatoid arthritis, are well known to cause gastroduodenal mucosal lesions as an adverse effect. Recently, the serious problem of NSAID-induced small intestinal damage has become a topic of great interest to gastroenterologists, since capsule endoscopy and double-balloon enteroscopy are available for the detection of small intestinal lesions. Such lesions have been of great concern in clinical settings, and their treatment and prevention must be devised as soon as possible. Proton pump inhibitors (PPI), such as lansoprazole and omeprazole, show a potent anti-secretory effect. PPIs also have a gastroprotective effect, independent of their anti-secretory actions, which is probably mediated by inhibition of neutrophil functions as well as antioxidant actions. Administration of lansoprazole reduced the severity of the intestinal lesions in a dose-dependent manner, but omeprazole had no effect. The amount of heme oxygenase-1 (HO-1) protein in the intestinal mucosa was significantly increased by lansoprazole, but not by omeprazole. These results suggest that lansoprazole, but not omeprazole, ameliorates indomethacin-induced small intestinal ulceration through upregulation of HO-1/carbon monoxide. Therefore, lansoprazole may be useful for preventing the adverse effects of NSAIDs not only in the stomach but also in the small intestine
Search for Radiative Decays of Cosmic Background Neutrino using Cosmic Infrared Background Energy Spectrum
We propose to search for the neutrino radiative decay by fitting a photon
energy spectrum of the cosmic infrared background to a sum of the photon energy
spectrum from the neutrino radiative decay and a continuum. By comparing the
present cosmic infrared background energy spectrum observed by AKARI and
Spitzer to the photon energy spectrum expected from neutrino radiative decay
with a maximum likelihood method, we obatined a lifetime lower limit of to years at 95% confidence level for the
third generation neutrino in the mass range between 50 \mmev
and 150 \mmev under the present constraints by the neutrino oscillation
measurements. In the left-right symmetric model, the minimum lifetime of
is predicted to be years for of 50 \mmev. We
studied the feasibility of the observation of the neutrino radiative decay with
a lifetime of years, by measuring a continuous energy
spectrum of the cosmic infrared background
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