5,605 research outputs found
New "Cats" in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed Metalloenzymes.
The Wisdom of the Strict Locality Rule
Unlike the preceding article, this article favors the retention of the strict locality rule in medical malpractice cases in Maryland. The authors, after analyzing many of the arguments put forth to liberalize or extinguish Maryland\u27s version of the strict locality rule, discuss the case history that has solidified Maryland\u27s position and demonstrate the justification for the rule\u27s continued application in this jurisdiction
The Wisdom of the Strict Locality Rule
Unlike the preceding article, this article favors the retention of the strict locality rule in medical malpractice cases in Maryland. The authors, after analyzing many of the arguments put forth to liberalize or extinguish Maryland\u27s version of the strict locality rule, discuss the case history that has solidified Maryland\u27s position and demonstrate the justification for the rule\u27s continued application in this jurisdiction
Flight investigation and analysis of the wing deformations on a swept-wing bomber during rolling maneuvers
Flight investigation and analysis of the wing deformations of a swept-wing bomber during push-pull maneuvers
High-resolution measurements of surface topography with airborne laser altimetry and the global positioning system
Recently, an airborne lidar system that measures laser pulse time-of-flight and the distortion of the pulse waveform upon reflection from earth surface terrain features was developed and is now operational. This instrument is combined with Global Positioning System (GPS) receivers and a two-axis gyroscope for accurate recovery of aircraft position and pointing attitude. The laser altimeter system is mounted on a high-altitude aircraft platform and operated in a repetitively-pulsed mode for measurements of surface elevation profiles at nadir. The laser transmitter makes use of recently developed short-pulse diode-pumped solid-state laser technology in Q-switched Nd:YAG operating at its fundamental wavelength of 1064 nm. A reflector telescope and silicon avalanche photodiode are the basis of the optical receiver. A high-speed time-interval unit and a separate high-bandwidth waveform digitizer under microcomputer control are used to process the backscattered pulses for measurements of terrain. Other aspects of the lidar system are briefly discussed
Degree Extension for Technicians (DEFT)
The Degree Extension for Technicians (DEFT) programme addresses a particular niche in Irish engineering education by offering qualified technicians (currently working in Irish electronics industry) an opportunity to undertake, principally via the Internet, a flexible learning programme leading to a professional engineering degree. This paper addresses the various aspects that make such a mode of learning appropriate to the programme and also looks at the motivation behind the decision to develop a new virtual learning environment (VLE) in-house. The paper also documents the implementation of a challenging project schedule which brought the DEFT programme and VLE to fruition over a 10-month period. The current status of the project, together with experiences to date, conclude the paper
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Reducing patients’ exposures to asthma and allergy triggers in their homes: an evaluation of effectiveness of grades of forced air ventilation filters
Objective: Many interventions to reduce allergen levels in the home are recommended to asthma and allergy patients. One that is readily available and can be highly effective is the use of high performing filters in forced air ventilation systems. Methods: We conducted a modeling analysis of the effectiveness of filter-based interventions in the home to reduce airborne asthma and allergy triggers. This work used “each pass removal efficiency” applied to health-relevant size fractions of particles to assess filter performance. We assessed effectiveness for key allergy and asthma triggers based on applicable particle sizes for cat allergen, indoor and outdoor sources of particles 70% for cat dander particles, fine particulate matter (PM2.5) and respiratory virus can lower concentrations of those asthma triggers and allergens in indoor air of the home by >50%. Very high removal efficiency filters, such as those rated a 16 on the nationally recognized Minimum Efficiency Removal Value (MERV) rating system, tend to be only marginally more effective than MERV12 or 13 rated filters. Conclusions: The results of this analysis indicate that use of a MERV12 or higher performing air filter in home ventilation systems can effectively reduce indoor levels of these common asthma and allergy triggers. These reductions in airborne allergens in turn may help reduce allergy and asthma symptoms, especially if employed in conjunction with other environmental management measures recommended for allergy and asthma patients
Microbial mats in the Turks and Caicos Islands reveal diversity and evolution of phototrophy in the Chloroflexota order Aggregatilineales
Genome-resolved metagenomic sequencing approaches have led to a substantial increase in the recognized diversity of microorganisms; this included the discovery of novel metabolic pathways in previously recognized clades, and has enabled a more accurate determination of the extant distribution of key metabolisms and how they evolved over Earth history. Here, we present metagenome-assembled genomes of members of the Chloroflexota (formerly Chloroflexi or Green Nonsulfur Bacteria) order Aggregatilineales (formerly SBR1031 or Thermofonsia) discovered from sequencing of thick and expansive microbial mats present in an intertidal lagoon on Little Ambergris Cay in the Turks and Caicos Islands. These taxa included multiple new lineages of Type 2 reaction center-containing phototrophs that were not closely related to previously described phototrophic Chloroflexota—revealing a rich and intricate history of horizontal gene transfer and the evolution of phototrophy and other core metabolic pathways within this widespread phylum
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