411 research outputs found

    Symbiotic Bright Solitary Wave Solutions of Coupled Nonlinear Schrodinger Equations

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    Conventionally, bright solitary wave solutions can be obtained in self-focusing nonlinear Schrodinger equations with attractive self-interaction. However, when self-interaction becomes repulsive, it seems impossible to have bright solitary wave solution. Here we show that there exists symbiotic bright solitary wave solution of coupled nonlinear Schrodinger equations with repulsive self-interaction but strongly attractive interspecies interaction. For such coupled nonlinear Schrodinger equations in two and three dimensional domains, we prove the existence of least energy solutions and study the location and configuration of symbiotic bright solitons. We use Nehari's manifold to construct least energy solutions and derive their asymptotic behaviors by some techniques of singular perturbation problems.Comment: to appear in Nonlinearit

    A 3D Model of the Membrane Protein Complex Formed by the White Spot Syndrome Virus Structural Proteins

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    Outbreaks of white spot disease have had a large negative economic impact on cultured shrimp worldwide. However, the pathogenesis of the causative virus, WSSV (whit spot syndrome virus), is not yet well understood. WSSV is a large enveloped virus. The WSSV virion has three structural layers surrounding its core DNA: an outer envelope, a tegument and a nucleocapsid. In this study, we investigated the protein-protein interactions of the major WSSV structural proteins, including several envelope and tegument proteins that are known to be involved in the infection process.In the present report, we used coimmunoprecipitation and yeast two-hybrid assays to elucidate and/or confirm all the interactions that occur among the WSSV structural (envelope and tegument) proteins VP51A, VP19, VP24, VP26 and VP28. We found that VP51A interacted directly not only with VP26 but also with VP19 and VP24. VP51A, VP19 and VP24 were also shown to have an affinity for self-interaction. Chemical cross-linking assays showed that these three self-interacting proteins could occur as dimers.From our present results in conjunction with other previously established interactions we construct a 3D model in which VP24 acts as a core protein that directly associates with VP26, VP28, VP38A, VP51A and WSV010 to form a membrane-associated protein complex. VP19 and VP37 are attached to this complex via association with VP51A and VP28, respectively. Through the VP26-VP51C interaction this envelope complex is anchored to the nucleocapsid, which is made of layers of rings formed by VP664. A 3D model of the nucleocapsid and the surrounding outer membrane is presented

    Polymers imprinted with three REG1B peptides for electrochemical determination of Regenerating Protein 1B, a urinary biomarker for pancreatic ductal adenocarcinoma

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    Three peptides (each containing 13–18 amino acids) were synthesized and used as templates for molecular imprinting and epitope recognition of the Regenerating Protein 1B (REG1B), which is one of the urinary biomarkers for pancreatic ductal adenocarcinoma (PDAC). Poly(ethylene-co-vinyl alcohol)s were employed as the host for molecular imprinting of the peptides. Following their preparation, the molecularly imprinted polymers (MIP) were examined by cyclic voltammetry. The electrochemical responses of a screen-printed gold substrate coated with the MIP were measured at a working voltage of 300 mV (vs. Ag/AgCl); the entire protein and the peptides gave similar responses at concentrations of <1.0 pg⋅mL−1, with detection limits as low as 0.1 pg⋅mL−1. Urine samples from healthy and PDAC patients were then analyzed by using this modified gold electrode, and the results are in agreement with data obtained with ELISA

    Longitudinal double-spin asymmetry and cross section for inclusive jet production in polarized proton collisions at sqrt(s) = 200 GeV

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    We report a measurement of the longitudinal double-spin asymmetry A_LL and the differential cross section for inclusive midrapidity jet production in polarized proton collisions at sqrt(s)=200 GeV. The cross section data cover transverse momenta 5 < pT < 50 GeV/c and agree with next-to-leading order perturbative QCD evaluations. The A_LL data cover 5 < pT < 17 GeV/c and disfavor at 98% C.L. maximal positive gluon polarization in the polarized nucleon.Comment: 6 pages, 3 figures. Minor changes from review process in Phys. Rev. Lett. Plain text tables of data in STAR publications may be found at http://www.star.bnl.gov/central/publications

    Identified baryon and meson distributions at large transverse momenta from Au+Au collisions at sNN=200\sqrt{s_{_{NN}}} = 200 GeV

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    Transverse momentum spectra of π±\pi^{\pm}, pp and pˉ\bar{p} up to 12 GeV/c at mid-rapidity in centrality selected Au+Au collisions at sNN=200\sqrt{s_{_{NN}}} = 200 GeV are presented. In central Au+Au collisions, both π±\pi^{\pm} and p(pˉ)p(\bar{p}) show significant suppression with respect to binary scaling at pT>p_T > 4 GeV/c. Protons and anti-protons are less suppressed than π±\pi^{\pm}, in the range 1.5 <pT<< p_{T} <6 GeV/c. The π/π+\pi^-/\pi^+ and pˉ/p\bar{p}/p ratios show at most a weak pTp_T dependence and no significant centrality dependence. The p/πp/\pi ratios in central Au+Au collisions approach the values in p+p and d+Au collisions at pT>p_T > 5 GeV/c. The results at high pTp_T indicate that the partonic sources of π±\pi^{\pm}, pp and pˉ\bar{p} have similar energy loss when traversing the nuclear medium.Comment: 6 pages, 4 figure

    Surface-Initiated Polymer Brushes in the Biomedical Field: Applications in Membrane Science, Biosensing, Cell Culture, Regenerative Medicine and Antibacterial Coatings

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