4,151 research outputs found
Biocompatibility of a lab-on-a-pill sensor in artificial gastrointestinal environments
n this paper, we present a radiotelemetry sensor, designed as a lab-in-a-pill, which incorporates a two-channel microfabricated sensor platform for real-time measurements of temperature and pH. These two parameters have potential application for use in remote biological sensing (for example they may be used as markers that reflect the physiological environment or as indicators for disease, within the gastrointestinal tract). We have investigated the effects of biofouling on these sensors, by exploring their response time and sensitivity in a model in vitro gastrointestinal system. The artificial gastric and intestinal solutions used represent a model both for fasting, as well as for the ingestion of food and subsequent digestion to gastrointestinal chyme. The results showed a decrease in pH sensitivity after exposure of the sensors for 3 h. The response time also increased from an initial measurement time of 10 s in pure GI juice, to ca. 25 s following the ingestion of food and 80 s in simulated chyme. These in vitro results indicate that changes in viscosity in our model gastrointestinal system had a pronounced effect on the unmodified sensor
A programmable microsystem using system-on-chip for real-time biotelemetry
A telemetry microsystem, including multiple sensors, integrated instrumentation and a wireless interface has been implemented. We have employed a methodology akin to that for System-on-Chip microelectronics to design an integrated circuit instrument containing several "intellectual property" blocks that will enable convenient reuse of modules in future projects. The present system was optimized for low-power and included mixed-signal sensor circuits, a programmable digital system, a feedback clock control loop and RF circuits integrated on a 5 mm × 5 mm silicon chip using a 0.6 μm, 3.3 V CMOS process. Undesirable signal coupling between circuit components has been investigated and current injection into sensitive instrumentation nodes was minimized by careful floor-planning. The chip, the sensors, a magnetic induction-based transmitter and two silver oxide cells were packaged into a 36 mm × 12 mm capsule format. A base station was built in order to retrieve the data from the microsystem in real-time. The base station was designed to be adaptive and timing tolerant since the microsystem design was simplified to reduce power consumption and size. The telemetry system was found to have a packet error rate of 10<sup>-</sup><sup>3</sup> using an asynchronous simplex link. Trials in animal carcasses were carried out to show that the transmitter was as effective as a conventional RF device whilst consuming less power
Modeling flocculation processes: continuous particle size distribution method
The flocculation process of cohesive sediment suspended in water consists of aggregation of the fine particles and breakup of the large flocs. The population balance equation (PBE) is a statement of continuity for particulate systems, and it is used to model the flocculation process and predict the particle size distribution (PSD). Different numerical methods are developed to solve the PBE, however most of the methods have difficulties in representing the continuous PSD or improving computational efficiency. In this research, the B-spline FEM and Galerkin FEM are studied to simulate the continuous PSD. The B-spline FEM solves the PBE over the whole domain, which is truncated to finite domain; the open non-uniform B-splines are used as basis function to approximate the PSD; the curve of PSD is required to be smooth enough. The Galerkin FEM discretizes the PBE on each sub-domain (the whole domain is split to several sub-domains), and it is used to solve less-smooth problems. The adaptive technique is applied to readjust the computational grid (particle size domain) to improve computational efficiency and the accuracy, and it is also applied in varied time step to get suitable time step to improve the stability. The analytical solutions of the PBE in special conditions and the experimental data are used to validate both B-spline FEM and Galerkin FEM, and the results are compared with that of the classical DPBE method. It shows that both B-spline FEM and Galerkin FEM can solve the PBE and simulate continuous PSD accurately and efficiently
Theory of bound polarons in oxide compounds
We present a multilateral theoretical study of bound polarons in oxide
compounds MgO and \alpha-Al_2O_3 (corundum). A continuum theory at arbitrary
electron-phonon coupling is used for calculation of the energies of thermal
dissociation, photoionization (optically induced release of an electron (hole)
from the ground self-consistent state), as well as optical absorption to the
non-relaxed excited states. Unlike the case of free strong-coupling polarons,
where the ratio \kappa of the photoionization energy to the thermal
dissociation energy was shown to be always equal to 3, here this ratio depends
on the Froehlich coupling constant \alpha and the screened Coulomb interaction
strength \beta. Reasonable variation of these two parameters has demonstrated
that the magnitude of \kappa remains usually in the narrow interval from 1 to
2.5. This is in agreement with atomistic calculations and experimental data for
hole O^- polarons bound to the cation vacancy in MgO. The thermal dissociation
energy for the ground self-consistent state and the energy of the optically
induced charge transfer process (hops of a hole between O^{2-} ions) have been
calculated using the quantum-chemical method INDO. Results obtained within the
two approaches for hole O polarons bound by the cation vacancies (V^-) in
MgO and by the Mg^{2+} impurity (V_{Mg}) in corundum are compared to
experimental data and to each other. We discuss a surprising closeness of the
results obtained on the basis of independent models and their agreement with
experiment.Comment: 13 pages, 2 figures, 2 tables, E-mail addresses:
[email protected], [email protected]
Leading-Order Actions of Goldstino Fields
This paper starts with a self-contained discussion of the so-called
Akulov-Volkov action S_AV, which is traditionally taken to be the leading-order
action of Goldstino field. Explicit expressions for S_AV and its chiral version
S_AV^ch are presented. We then turn to the issue on how these actions are
related to the leading-order action S_NL proposed in the newly proposed
constrained superfield formalism. We show that S_NL may yield S_AV/S_AV^ch or a
totally different action S_KS, depending on how the auxiliary field in the
former is integrated out. However, S_KS and S_AV/S_AV^ch always yield the same
S-matrix elements, as one would have expected from general considerations in
quantum field theory.Comment: Minor changes, version to appear in European Physical Journal
The ^4He trimer as an Efimov system
We review the results obtained in the last four decades which demonstrate the
Efimov nature of the He three-atomic system.Comment: Review article for a special issue of the Few-Body Systems journal
devoted to Efimov physic
Synthesis of gold micro- and nano-wires by infiltration and thermolysis
An approach for synthesizing micro- and nano-sized gold wires by infiltration and thermolysis is investigated. A porous ZrO2 ceramic preform with aligned pores obtained by unidirectional freezing and freeze-drying is employed as an infiltration template. The sintered porous ZrO2 preform is then infiltrated by a brushing gold solution. The thermolysis is conducted at 600 °C in air. Micro- and nano-sized gold wires are developed within the walls of the pores after thermolysis. The diameter of the gold wires ranges from several hundred nanometers to several microns
Real-Time Onboard Global Nonlinear Aerodynamic Modeling from Flight Data
Flight test and modeling techniques were developed to accurately identify global nonlinear aerodynamic models onboard an aircraft. The techniques were developed and demonstrated during piloted flight testing of an Aermacchi MB-326M Impala jet aircraft. Advanced piloting techniques and nonlinear modeling techniques based on fuzzy logic and multivariate orthogonal function methods were implemented with efficient onboard calculations and flight operations to achieve real-time maneuver monitoring and analysis, and near-real-time global nonlinear aerodynamic modeling and prediction validation testing in flight. Results demonstrated that global nonlinear aerodynamic models for a large portion of the flight envelope were identified rapidly and accurately using piloted flight test maneuvers during a single flight, with the final identified and validated models available before the aircraft landed
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