134 research outputs found

    A Review of the Criteria and Methods of Reverse Logistics Supplier Selection

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    This article presents a literature review on reverse logistics (RL) supplier selection in terms of criteria and methods. A systematic view of past work published between 2008 and 2020 on Web of Science (WOS) databases is provided by reviewing, categorizing, and analyzing relevant papers. Based on the analyses of 41 articles, we propose a three-stage typology of decision-making frameworks to understanding RL supplier selection, including (a) establishment of the selection criteria; (b) calculation of the relative weights and ranking of the selection criteria; (c) ranking of alternatives (suppliers). The main discoveries of this review are as follows. (1) Attention to the field of RL supplier selection is increasing, as evidenced by the increasing number of papers in the field. With the adaption of circular economy legislation and the need resource and business resilience, it is expected that RL and RL supplier selection will be a hot topic in the near future. (2) A large number of papers take “sustainability” as the theoretical approach to carry out research and use it as the basis for determining the criteria. (3) Multi-criteria decision making (MCDM) methods have been widely used in RL supplier selection and have been constantly innovated. (4) Artificial intelligence methods are also gradually being applied. Finally, gaps in the literature are identified to provide directions for future research. (5) Value-added service is underrepresented in the current study and needs further attention

    An Integrated Multicriteria Decision-Making Approach for Collection Modes Selection in Remanufacturing Reverse Logistics

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    Reverse logistics (RL) is closely related to remanufacturing and could have a profound impact on the remanufacturing industry. Different from sustainable development which is focused on economy, environment and society, circular economy (CE) puts forward more requirements on the circularity and resource efficiency of manufacturing industry. In order to select the best reverse logistics provider for remanufacturing, a multicriteria decision-making (MCDM) method considering the circular economy is proposed. In this article, a circularity dimension is included in the evaluation criteria. Then, analytic hierarchy process (AHP) is used to calculate the global weights of each criterion, which are used as the parameters in selecting RL providers. Finally, technique for order of preference by similarity to ideal solution (TOPSIS) is applied to rank reverse logistics providers with three different modes. A medium-sized engine manufacturer in China is taken as a case study to validate the applicability and effectiveness of the proposed framework

    Positive Solutions for Discrete Boundary Value Problems to One-Dimensional -Laplacian with Delay

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    We study the existence of positive solutions for discrete boundary value problems to one-dimensional -Laplacian with delay. The proof is based on the Guo-Krasnoselskii fixed-point theorem in cones. Two numerical examples are also provided to illustrate the theoretical results

    A Review on Remanufacturing Reverse Logistics Network Design and Model Optimization

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    Remanufacturing has gained great recognition in recent years due to its economic and environmental benefits and effectiveness in the value retention of waste products. Many studies on reverse logistics have considered remanufacturing as a key node for network optimization, but few literature reviews have explicitly mentioned remanufacturing as a main feature in their analysis. The aim of this review is to bridge this gap. In total, 125 papers on remanufacturing reverse logistics network design have been reviewed and conclusions have been drawn from four aspects: (1) in terms of network structure, the functional nodes of new hybrid facilities and the network structure combined with the remanufacturing technologies of products are the key points in the research. (2) In the mathematical model, the multi-objective function considered from different aspects, the uncertainty of recovery time and recovery channel in addition to quantity and quality, and the selection of appropriate algorithms are worth studying. (3) While considering product types, the research of a reverse logistics network of some products is urgently needed but inadequate, such as medical and furniture products. (4) As for cutting-edge technologies, the application of new technologies, such as intelligent remanufacturing technology and big data, will have a huge impact on the remanufacturing of a reverse logistics network and needs to be considered in our research

    Gypenosides Altered Hepatic Bile Acids Homeostasis in Mice Treated with High Fat Diet

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    Abstract Gypenosides extracted from Gynostemma pentaphyllum (Thunb.) Makino have significant role in reducing serum lipid level and treating fatty liver diseases, however, without clear mechanism. As gypenosides share the similar core structures with bile acids (the endogenous ligands of nuclear receptor FXR), we hypothesize that gypenosides may improve hypercholesterolemia via FXR-mediated bile acids signaling. The present study was designed to validate the role of gypenosides in reducing levels of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), as well as in regulating bile acids homeostasis and related gene expression levels. The C57BL/6 male mice were divided into four groups. Mice in groups ND and HFD were fed with normal diet and high fat diet for 38 weeks, respectively. In groups HFD+GP and HFD+ST, mice were fed with high fat diet for 38 weeks and treated with gypenosides and simvastatin (positive control) from weeks 16 to 38, respectively. Serum TC and LDL-C levels were assayed by commercially available kits. Expression levels of genes were tested by the quantitative real-time PCR. The LC-MS/MS was applied to quantify major bile acids in mice livers. Our results showed that gypenosides significantly decreased serum TC and LDL-C levels. The gene expression level of Shp was downregulated while the levels of Cyp7a1, Cyp8b1, Fxr, Lrh1, Jnk1/2, and Erk1/2were upregulated by gypenosides. Indicated by LC-MS/MS technology, gypenosides increased the hepatic levels of several free bile acids and most taurine-conjugated bile acids while decreasing glycine-conjugated bile acids levels. In addition, gypenosides decreased the CA/CDCA ratio. Gypenosides may improve the abnormal lipid profile of HFD-fed mice via two pathways: (1) enhancing the bile acids biosynthesis from cholesterol; (2) decreasing the CA/CDCA ratio which is positively related to cholesterol absorption

    A service-oriented energy assessment system based on BPMN and machine learning

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    Increasing energy cost and environmental problems push forward research on energy saving and emission reduction strategy in the manufacturing industry. Energy assessment of machining, as the basis for energy saving and emission reduction, plays an irreplaceable role in engineering service and maintenance for manufacturing enterprises. Due to the complex energy nature and relationships between machine tools, machining parts, and machining processes, there is still a lack of practical energy evaluation methods and tools for manufacturing enterprises. To fill this gap, a serviced-oriented energy assessment system is designed and developed to assist managers in clarifying the energy consumption of machining in this paper. Firstly, the operational requirements of the serviced-oriented energy assessment system are analyzed from the perspective of enterprises. Then, based on the establishment of system architecture, three key technologies, namely data integration, process integration, and energy evaluation, are studied in this paper. In this section, the energy characteristics of machine tools and the energy relationships are studied through the working states of machine tools, machining features of parts and process activities of processes, and the relational database, BPMN 2.0 specification, and machine learning approach are employed to implement the above function respectively. Finally, a case study of machine tool center stand base machining in a manufacturing enterprise was applied to verify the effectiveness and practicality of the proposed approach and system

    Neuroprotective Effect of Xueshuantong for Injection (Lyophilized) in Transient and Permanent Rat Cerebral Ischemia Model

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    Xueshuantong for Injection (Lyophilized) (XST), a Chinese Materia Medica standardized product extracted from Panax notoginseng (Burk.), is used extensively for the treatment of cerebrovascular diseases such as acutely cerebral infarction clinically in China. In the present study, we evaluated the acute and extended protective effects of XST in different rat cerebral ischemic model and explored its effect on peroxiredoxin (Prx) 6-toll-like receptor (TLR) 4 signaling pathway. We found that XST treatment for 3 days could significantly inhibit transient middle cerebral artery occlusion (MCAO) induced infarct volume and swelling percent and regulate the mRNA expression of interleukin-1Ī² (IL-1Ī²), IL-17, IL-23p19, tumor necrosis factor-Ī± (TNFĪ±), and inducible nitric oxide synthase (iNOS) in brain. Further study demonstrated that treatment with XST suppressed the protein expression of peroxiredoxin (Prx) 6-toll-like receptor (TLR) 4 and phosphorylation level of p38 and upregulated the phosphorylation level of STAT3. In permanent MCAO rats, XST could reduce the infarct volume and swelling percent. Moreover, our results revealed that XST treatment could increase the ratsā€™ weight and improve a batch of functional outcomes. In conclusion, the present data suggested that XST could protect against ischemia injury in transient and permanent MCAO rats, which might be related to Prx6-TLR4 pathway

    Patterns of co-morbidity with anxiety disorders in Chinese women with recurrent major depression

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    BACKGROUND: Studies conducted in Europe and the USA have shown that co-morbidity between major depressive disorder (MDD) and anxiety disorders is associated with various MDD-related features, including clinical symptoms, degree of familial aggregation and socio-economic status. However, few studies have investigated whether these patterns of association vary across different co-morbid anxiety disorders. Here, using a large cohort of Chinese women with recurrent MDD, we examine the prevalence and associated clinical features of co-morbid anxiety disorders. METHOD: A total of 1970 female Chinese MDD patients with or without seven co-morbid anxiety disorders [including generalized anxiety disorder (GAD), panic disorder, and five phobia subtypes] were ascertained in the CONVERGE study. Generalized linear models were used to model association between co-morbid anxiety disorders and various MDD features. RESULTS: The lifetime prevalence rate for any type of co-morbid anxiety disorder is 60.2%. Panic and social phobia significantly predict an increased family history of MDD. GAD and animal phobia predict an earlier onset of MDD and a higher number of MDD episodes, respectively. Panic and GAD predict a higher number of DSM-IV diagnostic criteria. GAD and blood-injury phobia are both significantly associated with suicidal attempt with opposite effects. All seven co-morbid anxiety disorders predict higher neuroticism. CONCLUSIONS: Patterns of co-morbidity between MDD and anxiety are consistent with findings from the US and European studies; the seven co-morbid anxiety disorders are heterogeneous when tested for association with various MDD features
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