7,834 research outputs found
The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma.
Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent years. ITH describes the cellular variation that enables tumour evolution, including tumour progression, metastasis and resistance to treatment. The selection and expansion of genetically distinct treatment-resistant cancer cell clones provides one explanation for treatment failure. However, tumour cell variation need not be genetically encoded. In pancreatic ductal adenocarcinoma (PDAC) in particular, the complex tumour microenvironment as well as crosstalk between tumour and stromal cells result in exceptionally variable tumour cell phenotypes that are also highly adaptable. In this review we discuss four different types of phenotypic heterogeneity within PDAC, from morphological to metabolic heterogeneity. We suggest that these different types of ITH are not independent, but, rather, can inform one another. Lastly, we highlight recent findings that suggest how therapeutic efforts may halt PDAC progression by constraining cellular heterogeneity
Realization of a Tunable Artificial Atom at a Supercritically Charged Vacancy in Graphene
The remarkable electronic properties of graphene have fueled the vision of a
graphene-based platform for lighter, faster and smarter electronics and
computing applications. One of the challenges is to devise ways to tailor its
electronic properties and to control its charge carriers. Here we show that a
single atom vacancy in graphene can stably host a local charge and that this
charge can be gradually built up by applying voltage pulses with the tip of a
scanning tunneling microscope (STM). The response of the conduction electrons
in graphene to the local charge is monitored with scanning tunneling and Landau
level spectroscopy, and compared to numerical simulations. As the charge is
increased, its interaction with the conduction electrons undergoes a transition
into a supercritical regime 6-11 where itinerant electrons are trapped in a
sequence of quasi-bound states which resemble an artificial atom. The
quasi-bound electron states are detected by a strong enhancement of the density
of states (DOS) within a disc centered on the vacancy site which is surrounded
by halo of hole states. We further show that the quasi-bound states at the
vacancy site are gate tunable and that the trapping mechanism can be turned on
and off, providing a new mechanism to control and guide electrons in grapheneComment: 18 pages and 5 figures plus 14 pages and 15 figures of supplementary
information. Nature Physics advance online publication, Feb 22 (2016
Lepton Jets in (Supersymmetric) Electroweak Processes
We consider some of the recent proposals in which weak-scale dark matter is
accompanied by a GeV scale dark sector that could produce spectacular
lepton-rich events at the LHC. Since much of the collider phenomenology is only
weakly model dependent it is possible to arrive at generic predictions for the
discovery potential of future experimental searches. We concentrate on the
production of dark states through bosons and electroweak-inos at the
Tevatron or LHC, which are the cleanest channels for probing the dark sector.
We properly take into account the effects of dark radiation and dark cascades
on the formation of lepton jets. Finally, we present a concrete definition of a
lepton jet and suggest several approaches for inclusive experimental searches.Comment: 23 pages, 13 figures, published version, added section 3.3 expanding
on lepton jet's morpholog
Heavy-to-light baryonic form factors at large recoil
We analyze heavy-to-light baryonic form factors at large recoil and derive
the scaling behavior of these form factors in the heavy quark limit. It is
shown that only one universal form factor is needed to parameterize Lambda_b to
p and Lambda_b to Lambda matrix elements in the large recoil limit of light
baryons, while hadronic matrix elements of Lambda_b to Sigma transition vanish
in the large energy limit of Sigma baryon due to the space-time parity
symmetry. The scaling law of the soft form factor eta(P^{\prime} \cdot v),
P^{\prime} and v being the momentum of nucleon and the velocity of Lambda_b
baryon, responsible for Lambda_b to p transitions is also derived using the
nucleon distribution amplitudes in leading conformal spin. In particular, we
verify that this scaling behavior is in full agreement with that from
light-cone sum rule approach in the heavy-quark limit. With these form factors,
we further investigate the Lambda baryon polarization asymmetry alpha in
Lambda_b to Lambda gamma and the forward-backward asymmetry A_{FB} in Lambda_b
to Lambda l^{+} l^{-}. Both two observables (alpha and A_{FB}) are independent
of hadronic form factors in leading power of 1/m_b and in leading order of
alpha_s. We also extend the analysis of hadronic matrix elements for Omega_b to
Omega transitions to rare Omega_b to Omega gamma and Omega_b to Omega l^{+}
l^{-} decays and find that radiative Omega_b to Omega gamma decay is probably
the most promising FCNC b to s radiative baryonic decay channel. In addition,
it is interesting to notice that the zero-point of forward-backward asymmetry
of Omega_b to Omega l^{+} l^{-} is the same as the one for Lambda_b to Lambda
l^{+} l^{-} to leading order accuracy provided that the form factors
\bar{\zeta}_i (i=3, 4, 5) are numerically as small as indicated from the quark
model.Comment: 19 page
An ultra-high gain and efficient amplifier based on Raman amplification in plasma
Raman amplification arising from the excitation of a density echelon in plasma could lead to amplifiers that significantly exceed current power limits of conventional laser media. Here we show that 1-100 J pump pulses can amplify picojoule seed pulses to nearly joule level. The extremely high gain also leads to significant amplification of backscattered radiation from "noise", arising from stochastic plasma fluctuations that competes with externally injected seed pulses, which are amplified to similar levels at the highest pump energies. The pump energy is scattered into the seed at an oblique angle with 14 J sr(-1), and net gains of more than eight orders of magnitude. The maximum gain coefficient, of 180 cm(-1), exceeds high-power solid-state amplifying media by orders of magnitude. The observation of a minimum of 640 J sr(-1) directly backscattered from noise, corresponding to approximate to 10% of the pump energy in the observation solid angle, implies potential overall efficiencies greater than 10%
Intergenerational change and familial aggregation of body mass index
The relationship between parental BMI and that of their adult offspring, when increased adiposity can become a clinical issue, is unknown. We investigated the intergenerational change in body mass index (BMI) distribution, and examined the sex-specific relationship
between parental and adult offspring BMI. Intergenerational
change in the distribution of adjusted BMI in 1,443
complete families (both parents and at least one offspring)
with 2,286 offspring (1,263 daughters and 1,023 sons) from
the west of Scotland, UK, was investigated using quantile
regression. Familial correlations were estimated from
linear mixed effects regression models. The distribution
of BMI showed little intergenerational change in the normal
range (\25 kg/m2), decreasing overweightness (25â
\30 kg/m2) and increasing obesity (C30 kg/m2). Median
BMI was static across generations in males and decreased
in females by 0.4 (95% CI: 0.0, 0.7) kg/m2; the 95th percentileincreased by 2.2 (1.1, 3.2) kg/m2 in males and 2.7
(1.4, 3.9) kg/m2 in females. Mothersâ BMI was more
strongly associated with daughtersâ BMI than was fathersâ
(correlation coefficient (95% CI): mothers 0.31 (0.27,
0.36), fathers 0.19 (0.14, 0.25); P = 0.001). Mothersâ and
fathersâ BMI were equally correlated with sonsâ BMI
(correlation coefficient: mothers 0.28 (0.22, 0.33), fathers
0.27 (0.22, 0.33). The increase in BMI between generations
was concentrated at the upper end of the distribution. This,
alongside the strong parent-offspring correlation, suggests that the increase in BMI is disproportionally greater among
offspring of heavier parents. Familial influences on BMI among middle-aged women appear significantly stronger from mothers than father
Optimum spectral window for imaging of art with optical coherence tomography
Optical Coherence Tomography (OCT) has been shown to have potential for important applications in the field of art conservation and archaeology due to its ability to image subsurface microstructures non-invasively. However, its depth of penetration in painted objects is limited due to the strong scattering properties of artistsâ paints. VIS-NIR (400 nm â 2400 nm) reflectance spectra of a wide variety of paints made with historic artistsâ pigments have been measured. The best spectral window with which to use optical coherence tomography (OCT) for the imaging of subsurface structure of paintings was found to be around 2.2 ÎŒm. The same spectral window would also be most suitable for direct infrared imaging of preparatory sketches under the paint layers. The reflectance spectra from a large sample of chemically verified pigments provide information on the spectral transparency of historic artistsâ pigments/paints as well as a reference set of spectra for pigment identification. The results of the paper suggest that broadband sources at ~2 microns are highly desirable for OCT applications in art and potentially material science in general
LHC diphoton Higgs signal and top quark forward-backward asymmetry in quasi-inert Higgs doublet model
In the quasi-inert Higgs doublet model, we study the LHC diphoton rate for a
standard model-like Higgs boson and the top quark forward-backward asymmetry at
Tevatron. Taking into account the constraints from the vacuum stability,
unitarity, electroweak precision tests, flavor physics and the related
experimental data of top quark, we find that compared with the standard model
prediction, the diphoton rate of Higgs boson at LHC can be enhanced due to the
light charged Higgs contributions, while the measurement of the top quark
forward-backward asymmetry at Tevatron can be explained to within due
to the non-standard model neutral Higgs bosons contributions. Finally, the
correlations between the two observables are discussed.Comment: 14 pages, 5 figues. Version to appear in JHEP, some references adde
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