Flow Structures of Gaseous Jets Injected into Water for Underwater Propulsion

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90659/1/AIAA-2011-185-740.pd

Flow Structures of Gaseous Jet Injected into Liquid for Underwater Propulsion

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/83627/1/AIAA-2010-6911-166.pd

Plasma kinetics: Discrete Boltzmann modelling and Richtmyer-Meshkov instability

A discrete Boltzmann model (DBM) for plasma kinetics is proposed. The constructing of DBM mainly considers two aspects. The first is to build a physical model with sufficient physical functions before simulation. The second is to present schemes for extracting more valuable information from massive data after simulation. For the first aspect, the model is equivalent to a magnetohydrodynamic model plus a coarse-grained model for the most relevant TNE behaviors including the entropy production rate. A number of typical benchmark problems including Orszag-Tang (OT) vortex problem are used to verify the physical functions of DBM. For the second aspect, the DBM use non-conserved kinetic moments of (f-feq) to describe non-equilibrium state and behaviours of complex system. The OT vortex problem and the Richtmyer-Meshkov instability (RMI) are practical applications of the second aspect. For RMI with interface inverse and re-shock process, it is found that, in the case without magnetic field, the non-organized momentum flux shows the most pronounced effects near shock front, while the non-organized energy flux shows the most pronounced behaviors near perturbed interface. The influence of magnetic field on TNE effects shows stages: before the interface inverse, the TNE strength is enhanced by reducing the interface inverse speed; while after the interface inverse, the TNE strength is significantly reduced. Both the global average TNE strength and entropy production rate contributed by non-organized energy flux can be used as physical criteria to identify whether or not the magnetic field is sufficient to prevent the interface inverse.Comment: 20 pages, 15 figure

Normative vs. patient-specific brain connectivity in deep brain stimulation

Brain connectivity profiles seeding from deep brain stimulation (DBS) electrodes have emerged as informative tools to estimate outcome variability across DBS patients. Given the limitations of acquiring and processing patient-specific diffusion-weighted imaging data, a number of studies have employed normative atlases of the human connectome. To date, it remains unclear whether patient-specific connectivity information would strengthen the accuracy of such analyses. Here, we compared similarities and differences between patient-specific, disease-matched and normative structural connectivity data and estimation of clinical improvement that they may generate. Data from 33 patients suffering from Parkinson's Disease who underwent surgery at three different centers were retrospectively collected. Stimulation-dependent connectivity profiles seeding from active contacts were estimated using three modalities, namely either patient-specific diffusion-MRI data, disease-matched or normative group connectome data (acquired in healthy young subjects). Based on these profiles, models of optimal connectivity were constructed and used to estimate the clinical improvement in out of sample data. All three modalities resulted in highly similar optimal connectivity profiles that could largely reproduce findings from prior research based on a novel multi-center cohort. In a data-driven approach that estimated optimal whole-brain connectivity profiles, out-of-sample predictions of clinical improvements were calculated. Using either patient-specific connectivity (R = 0.43 at p = 0.001), an age- and disease-matched group connectome (R = 0.25, p = 0.048) and a normative connectome based on healthy/young subjects (R = 0.31 at p = 0.028), significant predictions could be made and underlying optimal connectivity profiles were highly similar. Our results of patient-specific connectivity and normative connectomes lead to similar main conclusions about which brain areas are associated with clinical improvement. Still, although results were not significantly different, they hint at the fact that patient-specific connectivity may bear the potential of estimating slightly more variance when compared to group connectomes. Furthermore, use of normative connectomes involves datasets with high signal-to-noise acquired on specialized MRI hardware, while clinical datasets as the ones used here may not exactly match their quality. Our findings support the role of DBS electrode connectivity profiles as a promising method to investigate DBS effects and to potentially guide DBS programming