Erratum Re: “Coping With Racism: Moderators of the Discrimination—Distress Link Among Mexican-Origin Adolescents”

The publisher's final edited version of this article is available at Child Dev This corrects the article "Coping With Racism: Moderators of the Discrimination—Adjustment Link Among Mexican-Origin Adolescents" in Child Dev, volume 89 on page e293

Influence of an aperture on the performance of a two-degree-of-freedom iron-cored spherical permanent-magnet actuator

Abstract—This paper describes a computational and experimental study of a two-degree-of-freedom spherical permanent-magnet actuator equipped with an iron stator. In particular, it considers the effect of introducing an aperture in the stator core to facilitate access to the armature. The resultant magnetic field distribution in the region occupied by the stator windings, the net unbalanced radial force, and the resulting reluctance torque are determined by three-dimensional magnetostatic finite-element analysis. The predicted reluctance torque is validated experimentally, and its implications on actuator performance are described

The aromatic amino acid hydroxylase genes AAH1 and AAH2 in Toxoplasma gondii contribute to transmission in the cat

The Toxoplasma gondii genome contains two aromatic amino acid hydroxylase genes, AAH1 and AAH2 encode proteins that produce L-DOPA, which can serve as a precursor of catecholamine neurotransmitters. It has been suggested that this pathway elevates host dopamine levels thus making infected rodents less fearful of their definitive Felidae hosts. However, L-DOPA is also a structural precursor of melanins, secondary quinones, and dityrosine protein crosslinks, which are produced by many species. For example, dityrosine crosslinks are abundant in the oocyst walls of Eimeria and T. gondii, although their structural role has not been demonstrated, Here, we investigated the biology of AAH knockout parasites in the sexual reproductive cycle within cats. We found that ablation of the AAH genes resulted in reduced infection in the cat, lower oocyst yields, and decreased rates of sporulation. Our findings suggest that the AAH genes play a predominant role during infection in the gut of the definitive feline host

Conditioned place preference and locomotor activity in response to methylphenidate, amphetamine and cocaine in mice lacking dopamine D4 receptors

Methylphenidate (MP) and amphetamine (AMPH) are the most frequently prescribed medications for the treatment of attention-deficit/hyperactivity disorder (ADHD). Both drugs are believed to derive their therapeutic benefit by virtue of their dopamine (DA)-enhancing effects, yet an explanation for the observation that some patients with ADHD respond well to one medication but not to the other remains elusive. The dopaminergic effects of MP and AMPH are also thought to underlie their reinforcing properties and ultimately their abuse. Polymorphisms in the human gene that codes for the DA D4 receptor (D4R) have been repeatedly associated with ADHD and may correlate with the therapeutic as well as the reinforcing effects of responses to these psychostimulant medications. Conditioned place preference (CPP) for MP, AMPH and cocaine were evaluated in wild-type (WT) mice and their genetically engineered littermates, congenic on the C57Bl/6J background, that completely lack D4Rs (knockout or KO). In addition, the locomotor activity in these mice during the conditioning phase of CPP was tested in the CPP chambers. D4 receptor KO and WT mice showed CPP and increased locomotor activity in response to each of the three psychostimulants tested. D4R differentially modulates the CPP responses to MP, AMPH and cocaine. While the D4R genotype affected CPP responses to MP (high dose only) and AMPH (low dose only) it had no effects on cocaine. Inasmuch as CPP is considered an indicator of sensitivity to reinforcing responses to drugs these data suggest a significant but limited role of D4Rs in modulating conditioning responses to MP and AMPH. In the locomotor test, D4 receptor KO mice displayed attenuated increases in AMPH-induced locomotor activity whereas responses to cocaine and MP did not differ. These results suggest distinct mechanisms for D4 receptor modulation of the reinforcing (perhaps via attenuating dopaminergic signalling) and locomotor properties of these stimulant drugs. Thus, individuals with D4 receptor polymorphisms might show enhanced reinforcing responses to MP and AMPH and attenuated locomotor response to AMPH.Fil: Thanos, P. K.. NIAAA Intramural Program; Estados Unidos. Brookhaven National Laboratory; Estados Unidos. Universidad de Buenos Aires; ArgentinaFil: Bermeo, C.. Brookhaven National Laboratory; Estados UnidosFil: Rubinstein, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Suchland, K. L.. Oregon Health & Science University; Estados UnidosFil: Wang, G. J.. Brookhaven National Laboratory; Estados UnidosFil: Grandy, David K.. Oregon Health & Science University; Estados UnidosFil: Volkow, N. D.. NIAAA Intramural Program; Estados Unido

Magnetic Evolution and Temperature Variation in a Coronal Hole

We have explored the magnetic flux evolution and temperature variation in a coronal-hole region, using Big Bear Solar Observatory (BBSO) deep magnetograms and {\it SOHO}/EIT images observed from 2005 October 10 to 14. For comparison, we also investigated a neighboring quiet region of the Sun. The coronal hole evolved from its mature stage to its disappearance during the observing period. We have obtained the following results: (1) When the coronal hole was well developed on October 10, about 60 % of the magnetic flux was positive. The EUV brightness was 420 counts pixel$^{-1}$, and the coronal temperature, estimated from the line ratio of the EIT 195 {\AA} and 171 {\AA} images, was 1.07 MK. (2) On October 14, when the coronal hole had almost disappeared, 51 % of the magnetic flux was positive, the EUV radiance was 530 counts pixel$^{-1}$, and the temperature was 1.10 MK. (3) In the neighboring quiet region, the fraction of positive flux varied between 0.49 and 0.47. The EUV brightness displayed an irregular variation, with a mean value of 870 counts pixel$^{-1}$. The temperature was almost constant at 1.11 MK during the five-day observation. Our results demonstrate that in a coronal hole less imbalance of the magnetic flux in opposite polarities leads to stronger EUV brightness and higher coronal temperatures

Cyclic peptide oral bioavailability: lessons from the past

Achieving high oral bioavailability for drugs is a key design objective in drug development. It is not surprising then that with the growing expectation of peptides as future drugs, there has also been an increasing interest in developing oral peptide therapeutics. Brought to the fore are questions such as what makes peptides orally bioavailable and how this can be achieved; questions which have inspired research into the area for decades. Early research in the area focused on linear peptides with more recent literature focusing on cyclic peptides, motivated in part by cyclic peptides like cyclosporine A that have demonstrated drug-like oral bioavailability. In this review, we take a look at research on the oral bioavailability of peptides, focusing on factors that affect passive permeability

Field Effect Transistor Nanosensor for Breast Cancer Diagnostics

Silicon nanochannel field effect transistor (FET) biosensors are one of the most promising technologies in the development of highly sensitive and label-free analyte detection for cancer diagnostics. With their exceptional electrical properties and small dimensions, silicon nanochannels are ideally suited for extraordinarily high sensitivity. In fact, the high surface-to-volume ratios of these systems make single molecule detection possible. Further, FET biosensors offer the benefits of high speed, low cost, and high yield manufacturing, without sacrificing the sensitivity typical for traditional optical methods in diagnostics. Top down manufacturing methods leverage advantages in Complementary Metal Oxide Semiconductor (CMOS) technologies, making richly multiplexed sensor arrays a reality. Here, we discuss the fabrication and use of silicon nanochannel FET devices as biosensors for breast cancer diagnosis and monitoring

Normalizing Database Normalization Definitions In AIS Text Books

Due to the abstract nature of the definitions for normal forms, over the years the interpretations of the definitions published in the textbooks, both MIS and AIS disciplines, have been differentiated and even deviated from its original form. The concept of deviation from the original form is a phenomenon that linguists call “semantic drift.” The most noticeable deviations are on first and second normal forms (i.e., 1NF and 2NF). Their definitions range from “atomic attribute” to “removing repeating group” for 1NF and from “functional dependency” to “removing partial dependency” in addition to being 1NF for 2NF. The purpose of this paper is to compare definitions of first, second, and third normal forms from the textbooks with those of the earlier forms and to identify shortfalls if there are any

Ideal barriers to polarization reversal and domain-wall motion in strained ferroelectric thin films

The ideal intrinsic barriers to domain switching in c-phase PbTiO_3 (PTO), PbZrO_3 (PZO), and PbZr_{1-x}Ti_xO_3 (PZT) are investigated via first-principles computational methods. The effects of epitaxial strain on the atomic structure, ferroelectric response, barrier to coherent domain reversal, domain-wall energy, and barrier to domain-wall translation are studied. It is found that PTO has a larger polarization, but smaller energy barrier to domain reversal, than PZO. Consequentially the idealized coercive field is over two times smaller in PTO than PZO. The Ti--O bond length is more sensitive to strain than the other bonds in the crystals. This results in the polarization and domain-wall energy in PTO having greater sensitivity to strain than in PZO. Two ordered phases of PZT are considered, the rock-salt structure and a (100) PTO/PZO superlattice. In these simple structures we find that the ferroelectric properties do not obey Vergard's law, but instead can be approximated as an average over individual 5-atom unit cells.Comment: 9 pages, 13 figure