The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Multidisciplinary Team-based Model for Faculty Supports in Online Learning

This study examined the experiences of three new online instructors supported by a multidisciplinary, team-based model of course development and how their experiences may transform their knowledge of teaching and learning. In-depth, individual interviews with instructors during the course development process provided insights into participants’ perspectives. Analysis reveals faculty reflected positively on the overall development process and that they intend to incorporate new understandings in future course design, suggesting that the model provides a solid foundation for online course development and faculty support. Based on a cross-case analysis using Cranton’s (2002) adaptations to transformative learning theory, findings indicated the importance of critical reflection and discourse during the course development process. Lastly, the need for development teams to acknowledge time-management concerns and to consider instructors as novice learners is recognized as an essential requirement to online course development.    La présente étude se penche sur l’expérience de trois nouveaux instructeurs en ligne utilisant un modèle d’élaboration de cours multidisciplinaire fondé sur le travail d’équipe. Nous nous demandons comment cette expérience est susceptible de transformer leur connaissance de l’enseignement et de l’apprentissage. Des entrevues individuelles approfondies avec les instructeurs pendant l’élaboration des cours nous ont permis d’observer le point de vue des participants. Selon notre analyse, les enseignants ont formulé des réflexions positives au sujet du processus d’élaboration dans son ensemble. Ils ont dit vouloir incorporer leurs nouvelles connaissances dans la conception de leurs cours à l’avenir, ce qui suggère que le modèle constitue une assise solide pour l’élaboration de cours en ligne et pour le soutien des enseignants. Fondés sur une analyse transversale faisant usage des adaptations de Cranton (2002) aux théories de l’apprentissage transformationnel, nos résultats mettent en relief l’importance de la réflexion critique et du discours dans le processus d’élaboration des cours. Enfin, nous prenons acte du fait que l’équipe d’élaboration des cours doit prendre en compte les préoccupations en matière de gestion du temps et doit considérer les instructeurs comme des apprenants débutants. Ce sont là des exigences essentielles pour l’élaboration de cours en ligne

Using Interactive Technology to Disseminate Research Findings to a Diverse Population

This paper demonstrates how case stories can be used to disseminate the findings of several case studies on negotiating accommodations in the workplace. It highlights the power of interactive technology and of the partnership between the researchers and the Canadian Council for Rehabilitation and Work (CCRW). The paper describes the process of designing an interactive web-based case story for the purpose of disseminating research findings. The interactive case story is an extension of both the case study and the narrative case story. As part of a larger research project, it is our goal to use interactive case stories to investigate the impact of essential skills training on workers with disabilities who negotiate with employers for workplace accommodations. Résumé Le présent article montre comment les histoires de cas peuvent être utilisées pour diffuser les conclusions de plusieurs études de cas sur la négociation entourant l’aménagement du milieu de travail. Il met en évidence le pouvoir de la technologie interactive et du partenariat entre les chercheurs et le Conseil canadien de la réadaptation et du travail (CCRT). L’article décrit le processus de conception d’une histoire de cas interactive en ligne visant à diffuser des résultats de recherche. L’histoire de cas interactive est un prolongement à la fois de l’étude de cas et du récit de l’histoire de cas. Dans le cadre d’un plus vaste projet de recherche, notre but est d’utiliser des histoires de cas interactives pour étudier l’impact de la formation sur les compétences essentielles chez les travailleurs handicapés qui négocient avec leur employeur pour l’aménagement de leur milieu de travail

Bathymetric and microbial investigations at the Grimsey Vent Field (Iceland), Cruise No. AL595, 31.5. – 20.6.2023, Kiel (Germany) – Grimsey Vent Field (Iceland) – Kiel (Germany) AUV@GVF

During research cruise AL595 (31.5. - 20.6.2023) onboard research vessel ALKOR, investigations were carried out at the Grimsey Hydrothermal Field offshore Northern Iceland as part of the Helmholtz InnoPool project “High CO2 – metabolic responses and bioeconomic opportunities”. For the first time, the Hover-AUVs Anton and Luise were successfully operated at water depths of up to 400m, which is close to the maximum operational depth of 500m specified for these Girona 500 AUVs. AUV Anton was used to measure high resolution multibeam data with a horizontal resolution of approximately 40cm cov- ering a total area of ca. 1.4km2. AUV Luise acquired five photo-mosaics with sub-centimeter resolution covering a total area of ca. 5.000m2. In addition, both AUVs carried CTD probes, which will allow to investigate the local distribution of hydrothermal activity. Both high-resolution bathymetry and pho- togrammetry data yield new insights into the morphology and overall structure of the vent site and its surrounding, which will be valuable for the interpretation of geophysical data previously acquired in the working area. Sampling with a multicorer (three successful deployments), a 300cm long gravity corer (five successful deployments), a BIGO lander (two successful deployments) and casts with the CTD- rosette (seven deployments) generated fluid, pore-fluid and sediment samples to be analyzed by the working groups Geomicrobiology and Biogeochemistry, Marine Natural Products and Marine Geochem- istry at GEOMAR and at Matís (Iceland, Natural Products only). Lab work to be carried out in the home labs will yield insights into the physiological adaptation of microbial communities and individual microbes to very high CO2 concentrations and will explore microbial utilization of CO2 for establishing CO2-based bioeconomic value chains