79 research outputs found

    Particles-vortex interactions and flow visualization in He4

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    Recent experiments have demonstrated a remarkable progress in implementing and use of the Particle Image Velocimetry (PIV) and particle tracking techniques for the study of turbulence in He4. However, an interpretation of the experimental data in the superfluid phase requires understanding how the motion of tracer particles is affected by the two components, the viscous normal fluid and the inviscid superfluid. Of a particular importance is the problem of particle interactions with quantized vortex lines which may not only strongly affect the particle motion, but, under certain conditions, may even trap particles on quantized vortex cores. The article reviews recent theoretical, numerical, and experimental results in this rapidly developing area of research, putting critically together recent results, and solving apparent inconsistencies. Also discussed is a closely related technique of detection of quantized vortices negative ion bubbles in He4.Comment: To appear in the J Low Temperature Physic

    Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review

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    Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

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    Introduction: The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures. Methods: In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025. Findings: Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation. Interpretation: After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification. Funding: UK Research and Innovation and National Institute for Health Research

    Development of new wheat varieties for the pig industry: digestible energy yield of candidate wheats

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    Securing more reliable and consistent energy supplies for pig diets is one of the major challenges facing Australian pig production due to volatility of the international grain price and variable grain yields between seasons. A more reliable and consistent energy supply will reduce variation in the annual cost of pig feed and total cost of pig feed. The aim of this experiment was to identifY specific lines of wheat that are high yielding and contain high levels of digestible energy (DE) from the InterGrain (Kensington, WA) gene pool for potential commercial release

    Evaluative images and tourism: the use of personal constructs to describe the structure of destination images

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    Prior research at the regional scale suggests that two components underlie people\u27s evaluations of tourist destina tions: arousing-sleepy and pleasant-unpleasant. A study was undertaken to see if these dimensions also apply at the international and local levels. Although their relevance at the local level appeared to be masked by individuals\u27 personal experiences and knowledge, their applicability at the international scale supports the existence of an underlying general schema in environmental evaluation

    Spatio-temporal characterization and control of ultrashort pulses through a multiply scattering medium

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    Propagation of ultrashort broadband pulses through a multiply scattering media result in complex spatio-temporal speckle pattern. Using spectral pulse shaping, we demonstrate the spatially localized temporal recompression of the output speckle to the Fourier-limit duration

    Spatio-temporal characterization and control of ultrashort pulses through a multiply scattering medium

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    Propagation of ultrashort broadband pulses through a multiply scattering media result in complex spatio-temporal speckle pattern. Using spectral pulse shaping, we demonstrate the spatially localized temporal recompression of the output speckle to the Fourier-limit duration

    Resolving the molecular environment of super star clusters in Henize 2-10

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    Context: The rate of star formation both in the Galaxy and in external galaxies should be related to the physical properties of the molecular clouds from which stars form. This is expected for the starbursts found both in irregular galaxies and in some mergers. The dwarf galaxy Henize 2-10 is particularly interesting in this context as it shows a number of newly formed super star clusters (SSCs) associated with a very rich molecular environment. Aims: We present a high angular resolution study of the molecular gas associated with the SSCs with the aim of deriving the physical properties of the parent molecular clouds. The final goal is to test the expectation that the formation of SSCs requires exceptionally dense and massive clouds. Methods: We have used the Submillimeter Array with an angular resolution of 1.9 arcsec 7 1.3 arcsec to map the J = 2-1 transition of CO in Henize 2-10. Supplementary measurements of HCN(J = 1-0), 13CO(J = 2-1) and millimeter continuum were obtained with the APEX, IRAM 30 m and SEST single dish telescopes. Results: Our single dish observations confirm the association of the newly formed SSCs in Henize 2-10 with dense molecular gas. Our interferometric observations resolve the CO(2-1) emission in several giant molecular clouds. Overall the molecular gas accounts for approximately half of the mass in the central regions of Henize 2-10. Although we find indications that the molecular clouds associated with the formation of SSCs in Henize 2-10 are massive and dense, the tracer we used (CO) and the linear resolution of our observations (60 7 80 pc) are still not adequate to test the expectation that exceptionally dense and massive cores are required for SSCs formation
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