Corpus-Based Approaches to Figurative Language: Metaphor and Austerity

Austerity is a by-product of the ongoing financial crisis. As Kitson et al (2001) explain, what was a \u201cNICE\u201d (\u2018non-inflationary consistent expansion\u2019) economy has turned \u201cVILE\u201d (\u2018volatile inflation, little expansion\u2019), and the economic and social fall-out is now becoming visible. Unemployment, redundancy, inflation, recession, insecurity, and poverty all loom, causing governments, businesses and individuals to reevaluate their priorities. A changing world changes attitudes, and the earliest manifestations of such change can often be found in figurative language. Political rhetoric attempts to sweeten the bitter pill that nations have no choice but to swallow; all are invited to share the pain, make sacrifices for the common good, and weather the storm. But more sinister undertones can also be perceived. In times of social and financial dire straits, scapegoats are sought and mercilessly pursued in the press. The elderly, unemployed, and disabled are under fire for \u201csponging off the state\u201d; and as jobs become scarcer and the tax bill rises, migrant populations and asylum seekers are viewed with increasing suspicion and resentment. Calls for a \u201cbig society\u201d fall on deaf ears. Society, it seems, is shrinking as self-preservation takes hold. Austerity is a timely area of study: although austerity measures have been implemented in the past, most of the contributions here address the current political and economic situation, which means that some of the studies reported are work in progress while others look at particular \u201cwindows\u201d of language output from the recent past. Whichever their focus, the papers presented here feature up-to-the-minute research into the metaphors being used to comment upon our current socioeconomic situation. The picture of austerity that emerges from these snapshots is a complex one, and one which is likely to be developed further and more widely in the coming future

Evaluated kinetic and photochemical data for atmospheric chemistry: Volume V – heterogeneous reactions on solid substrates

This article, the fifth in the ACP journal series, presents data evaluated by the IUPAC Subcommittee on Gas Kinetic Data Evaluation for Atmospheric Chemistry. It covers the heterogeneous processes on surfaces of solid particles present in the atmosphere, for which uptake coefficients and adsorption parameters have been presented on the IUPAC website in 2010. The article consists of an introduction and guide to the evaluation, giving a unifying framework for parameterisation of atmospheric heterogeneous processes. We provide summary sheets containing the recommended uptake parameters for the evaluated processes. Four substantial appendices contain detailed data sheets for each process considered for ice, mineral dust, sulfuric acid hydrate and nitric acid hydrate surfaces, which provide information upon which the recommendations are made

Global warming potentials and radiative efficiencies of halocarbons and related compounds: a comprehensive review

In the mid-1970s it was recognized that, as well as being substances that deplete stratospheric ozone, chlorofluorocarbons (CFCs) were strong greenhouse gases that could have substantial impacts on radiative forcing of climate change. Around a decade later, this group of radiatively active compounds was expanded to include a large number of replacements for ozone-depleting substances such as chlorocarbons, hydrochlorocarbons, hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), bromofluorocarbons, and bromochlorofluorocarbons. This paper systematically reviews the published literature concerning the radiative efficiencies (REs) of CFCs, bromofluorocarbons and bromochlorofluorocarbons (halons), HCFCs, HFCs, PFCs, SF6, NF3, and related halogen containing compounds. In addition we provide a comprehensive and self-consistent set of new calculations of REs and global warming potentials (GWPs) for these compounds, mostly employing atmospheric lifetimes taken from the available literature. We also present Global Temperature change Potentials (GTPs) for selected gases. Infrared absorption spectra used in the RE calculations were taken from databases and individual studies, and from experimental and ab initio computational studies. Evaluations of REs and GWPs are presented for more than 200 compounds. Our calculations yield REs significantly (> 5%) different from those in the Intergovernmental Panel on Climate Change Fourth Assessment Report (AR4) for 49 compounds. We present new RE values for more than 100 gases which were not included in AR4. A widely-used simple method to calculate REs and GWPs from absorption spectra and atmospheric lifetimes is assessed and updated. This is the most comprehensive review of the radiative efficiencies and global warming potentials of halogenated compounds performed to date

Atmospheric chemistry of cyclohexanone: UV spectrum and kinetics of reaction with chlorine atoms

Absolute and relative rate techniques were used to study the reactivity of Cl atoms with cyclohexanone in 6 Torr of argon or 800–950 Torr of N 2 at 295 ± 2 K. The absolute rate experiments gave k (Cl + cyclohexanone) = (1.88 ± 0.38) × 10 −10 , whereas the relative rate experiments gave k (Cl + cyclohexanone) = (1.66 ± 0.26) × 10 −10 cm 3 molecule −1 s −1 . Cyclohexanone has a broad UV absorption band with a maximum cross section of (4.0 ± 0.3) × 10 −20 cm 2 molecule −1 near 285 nm. The results are discussed with respect to the literature data. © 2008 Wiley Periodicals, Inc. Int J Chem Kinet 40: 223–229, 2008Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58072/1/20291_ftp.pd

A multidisciplinary engineering summer school in an industrial setting

Most university-level engineering studies produce technically skilled engineers. However, typically students face several difficulties whenworking in multidisciplinary teams when they initiate their industrial careers. In a globalised world, it becomes increasingly important that engineers are capable of collaborating across disciplinary boundaries and exhibit soft competencies, like communication, interpersonal and social skills, time planning, creativity, initiative, and reflection. To prepare a group of engineering and industrial design students to acquire those capabilities, an international summer school that combined industrial design with different kinds of engineering disciplineswas organised on the site of Bang&Olufsen (B&O) in Denmark. This multidisciplinary engineering summer school was attended by students from six European university-level teaching institutions and was supervised by teachers from those institutions and industrial experts from B&O. The main aim of the summer school was to allow students to work in teams, composed of students from different knowledge disciplines and with different cultural backgrounds, with the purpose of developing innovative concepts and products, within a strong industrial perspective.B&OERASMU

Evaluated kinetic and photochemical data for atmospheric chemistry: Volume IV – gas phase reactions of organic halogen species

This article, the fourth in the series, presents kinetic and photochemical data sheets evaluated by the IUPAC Subcommittee on Gas Kinetic Data Evaluation for Atmospheric Chemistry. It covers the gas phase and photochemical reactions of organic halogen species, which were last published in 1997, and were updated on the IUPAC website in 2006/07. The article consists of a summary sheet, containing the recommended kinetic parameters for the evaluated reactions, and four appendices containing the data sheets, which provide information upon which the recommendations are made

Reduced stomatal density in bread wheat leads to increased water-use efficiency

Wheat is a staple crop, frequently cultivated in water-restricted environments. Improving crop water-use efficiency would be desirable if grain yield can be maintained. We investigated whether a decrease in wheat stomatal density via the manipulation of epidermal patterning factor (EPF) gene expression could improve water-use efficiency. Our results show that severe reductions in stomatal density in EPF-overexpressing wheat plants have a detrimental outcome on yields. However, wheat plants with a more moderate reduction in stomatal density (i.e. <50% reduction in stomatal density on leaves prior to tillering) had yields indistinguishable from controls, coupled with an increase in intrinsic water-use efficiency. Yields of these moderately reduced stomatal density plants were also comparable with those of control plants under conditions of drought and elevated CO2. Our data demonstrate that EPF-mediated control of wheat stomatal development follows that observed in other grasses, and we identify the potential of stomatal density as a tool for breeding wheat plants that are better able to withstand water-restricted environments without yield loss

Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress

Published: April 14, 2017The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production of malignant plasma cells, bortezomib induces endoplasmic reticulum (ER) stress and the unfolded protein response (UPR), resulting in myeloma cell death. In most cases, however, the disease remains incurable highlighting the need for new therapeutic targets. Sphingosine kinase 2 (SK2) has been proposed as one such therapeutic target for myeloma. Our observations that bortezomib and SK2 inhibitors independently elicited induction of ER stress and the UPR prompted us to examine potential synergy between these agents in myeloma. Targeting SK2 synergistically contributed to ER stress and UPR activation induced by bortezomib, as evidenced by activation of the IRE1 pathway and stress kinases JNK and p38MAPK, thereby resulting in potent synergistic myeloma apoptosis in vitro. The combination of bortezomib and SK2 inhibition also exhibited strong in vivo synergy and favourable effects on bone disease. Therefore, our studies suggest that perturbations of sphingolipid signalling can synergistically enhance the effects seen with proteasome inhibition, highlighting the potential for the combination of these two modes of increasing ER stress to be formally evaluated in clinical trials for the treatment of myeloma patients.Craig T. Wallington-Beddoe, Melissa K. Bennett, Kate Vandyke, Lorena Davies, Julia R. Zebol, Paul A.B. Moretti, Melissa R. Pitman, Duncan R. Hewett, Andrew C.W. Zannettino and Stuart M. Pitso