Temporary Protection: Towards a New Regional and Domestic Framework

During the past thirty-five years, the United States has seen the direct influx of thousands of individuals leaving politically unstable countries. While some seeking entry have proved themselves to be refugees and obtained permanent protection in the United States, far more, including a large number of people fleeing civil war, natural disasters, or comparable forms of upheaval in their home countries, have failed to demonstrate that they would be targets of persecution. Yet, their return to their home countries has been complicated by the very circumstances that led to their flight: conflict, violence, and repression. Over time, the United States developed a series of ad hoc responses that protected such individuals, culminating in the Immigration Act of 1990 (“IMMACT”), which provided legislative authority for Temporary Protected Status (“TPS”). Nevertheless, after eight years, many problems remain in the application of the law. Solving these problems will contribute both to better immigration control and more humane responses to future crises. Current policies fail on two accounts. First, the temporary protection provision in the law generally has failed to protect the vast majority of those in danger as a crisis develops and unfolds. If the United States government protects significant numbers at all, protection is provided outside the confines of the United States. Even so, the mechanisms for responding extraterritorially are not well developed. Second, current policies regarding protection in the United States do not provide the control mechanisms to ensure that protection is not abused and that return, when appropriate, is effected. The choice to admit people for temporary protection has been a difficult one for the United States for two main reasons: the lack of control over entry; and the inability to implement a fair but firm end game. These constraints together with the fear of litigation challenging domestic protection regimes have led policymakers to keep protection seekers offshore, such as on Guantanamo, or to return them directly to countries they fled without providing an opportunity for them to present requests for protection. But not having a fully developed regional or domestic capability for addressing these complex movements comes at a considerable cost. Estimates for the agency costs of handling the 1994 Cuban exodus through the use of offshore safe havens were more than $500 million. Further, an immigration system that cannot fairly and efficiently process protection seekers lacks credibility for which it pays a significant public cost

Which Program for Whom? Evidence on the Comparative Effectiveness of Public Sponsored Training Programs in Germany

We use a new and exceptionally rich administrative data set for Germany to evaluate the employment effects of a variety of public sponsored training programs in the early 2000s. Building on the work of Sianesi (2003, 2004), we employ propensity score matching methods in a dynamic, multiple treatment framework in order to address program heterogeneity and dynamic selection into programs. Our results suggest that in West Germany both short-term and medium-term programs show considerable employment effects for certain population subgroups but in some cases the effects are zero in the medium run. Short-term programs are surprisingly effective when compared to the traditional and more expensive longer-term programs. With a few exceptions, we find little evidence for significant positive treatment effects in East Germany. There is some evidence that the employment effects decline for older workers and for low? skilled workers. --evaluation,multiple treatments,dynamic treatment effects,local linear matching,active labor market programs,administrative data

Subterranean Loss and Gain of Water in Mountain Lake, Virginia: A Hydrologic Model

Mountain Lake, Virginia is a small, unique, oligotrophic, subalpine ecosystem in the southern Appalachians. Previous studies have disclosed that this lake has manifested periodic prolonged low water levels during the several thousand years of its existence. The most recent low water level occurred during the drought years of 1999-2002. Measurements of lake level, precipitation, and other meteorological data including calculated evapotranspiration in the lake basin from 2/19/02 to 8/31/03 have enabled estimation of net subterranean water losses presumably through cracks between Clinch sandstone boulders and/or the recently discovered deep hole at the northwest end of Mountain Lake. These net losses reflect the balance between total losses and any gains from springs and boulder cracks not quantified in this study. Scuba divers have documented the existence of these cracks and the deep hole. Subterranean net water losses of about 0.04-0.05 m3/s (634-792 gpm) apparently occur year-round

The role of EphA2 in ADAM17- and ionizing radiation-enhanced lung cancer cell migration

PURPOSE Ionizing radiation (IR) enhances the migratory capacity of cancer cells. Here we investigate in non-small-cell-lung-cancer (NSCLC) cells a novel link between IR-enhanced ADAM17 activity and the non-canonical pathway of EphA2 in the cellular stress response to irradiation. METHODS Cancer cell migration in dependence of IR, EphA2, and paracrine signaling mediated by ADAM17 was determined using transwell migration assays. Changes of EphA2 pS897 and mRNA expression levels upon different ADAM17-directed treatment strategies, including the small molecular inhibitor TMI-005, the monoclonal antibody MEDI3622, and shRNAs, were mechanistically investigated. ADAM17-mediated release and cleavage of the EphA2 ligand ephrin-A1 was measured using ELISA and an acellular cleavage assay. RESULTS Irradiation with 5 Gy enhanced tumor cell migration of NSCLC NCI-H358 cells in dependence of EphA2. At the same time, IR increased growth factor-induced EphA2 S897 phosphorylation via auto- and paracrine signaling. Genetic and pharmaceutical downregulation of ADAM17 activity abrogated growth factor (e.g. amphiregulin) release, which reduced MAPK pathway-mediated EphA2 S897 phosphorylation in an auto- and paracrine way (non-canonical EphA2-pathway) in NCI-H358 and A549 cells. These signaling processes were associated with reduced cell migration towards conditioned media derived from ADAM17-deficient cells. Interestingly, ADAM17 inhibition with the small molecular inhibitor TMI-005 led to the internalization and proteasomal degradation of EphA2, which was rescued by amphiregulin or MG-132 treatment. In addition, ADAM17 inhibition also abrogated ephrin-A1 cleavage and thereby interfered with the canonical EphA2-pathway. CONCLUSION We identified ADAM17 and the receptor tyrosine kinase EphA2 as two important drivers for (IR-) induced NSCLC cell migration and described a unique interrelation between ADAM17 and EphA2. We demonstrated that ADAM17 influences both, EphA2 (pS897) and its GPI-anchored ligand ephrin-A1. Using different cellular and molecular readouts, we generated a comprehensive picture of how ADAM17 and IR influence the EphA2 canonical and non-canonical pathway in NSCLC cells

Testing key messages about extending cervical screening intervals

Objectives: We tested the impact of different messages about the rationale for extended screening intervals on acceptability of an extension. Methods: Women in England aged 25-49 years (n=2931) were randomised to read different messages about extending intervals from 3 to 5 years. Outcome measures were general acceptability and six components from the Theoretical Framework of Acceptability (TFA). Results: The control group were less likely to find the change acceptable (43%) than the groups who saw additional messages (47-63%). Women who saw messages about interval safety, test accuracy or the speed of cell changes had more positive affective attitudes, higher ethicality beliefs, a better understanding of the reasons for the interval change and were more likely to believe that 5-year intervals would be safe. Being up-to-date with screening and previous abnormal results were associated with finding 5-yearly screening unacceptable. Conclusions: Emphasising the slow development of cell changes following an HPV negative result and the safety of longer intervals, alongside messages about the accuracy of HPV primary screening is important

The impact of age-relevant and generic infographics on knowledge, attitudes and intention to attend cervical screening: A randomized controlled trial

OBJECTIVES: Cervical screening uptake in England is falling. Infographics could strengthen intention to attend, increase positive attitudes and improve knowledge. Age targeting could improve these outcomes further. We tested the impact of generic and age-targeted infographics. DESIGN: A randomized controlled trial using an age-stratified, parallel-group design. METHODS: Women aged 25-64 (n = 2095) were recruited through an online panel and randomized to see one of the three infographics. We tested: (i) impact of a generic cervical screening infographic compared to a control infographic on an unrelated topic with all screening age women and (ii) impact of an age-targeted infographic compared to a generic cervical screening infographic with older women (50-64 years). Intentions, knowledge and attitudes were measured. RESULTS: Women aged 25-64 years who viewed the generic infographic had significantly higher intentions [F(1, 1513) = 6.14, p = .013, η p 2 $${\eta}_p^2$$  = .004], more accurate beliefs about the timeline of cervical cancer development (OR: 5.18, 95% CI: 3.86-6.95), more accurate social norms (OR: 3.03, 95% CI: 2.38-3.87) and more positive beliefs about screening benefits (OR: 2.23, 95% CI: 1.52-3.28) than those viewing the control infographic. In the older age group, there was no significant difference in intention between those viewing the generic versus age-targeted versions [F(1, 607) = .03, p = .853, η p 2 $${\eta}_p^2$$  < .001], but the age-targeted version was more engaging [F(1, 608) = 9.41, p = .002, η p 2 $${\eta}_p^2$$  = .015]. CONCLUSIONS: A cervical screening infographic can result in more positive attitudes and better knowledge and may have a small impact on intentions. Although age targeting did not affect intention, it had a positive impact on engagement and may therefore be useful in encouraging women to read and process materials

Beschäftigungseffekte ausgewählter Maßnahmen der beruflichen Weiterbildung in Deutschland : eine Bestandsaufnahme (Effects of selected measures of further vocational training in Germany : an appraisal)

"New administrative data have recently permitted a differentiated and dynamic evaluation of the employment effects of measures of further vocational training in Germany which have been conducted in the context of active labour market policy. The data available for this purpose include firstly data for the time of the Employment Promotion Act in the 1980s and 1990s, and secondly the data of the Integrated Employment Biographies (Integrierten Erwerbsbiografien (IEB)) for the Social Code III from the year 2000 onwards. The aim of this paper is to assess the results of currently presented evaluations on the basis of these new data sets. We report results from other studies as well as those from our own studies. The results show that the employment effects of measures of further vocational training are far more positive than suggested by studies conducted in the past on the basis of survey data. It can be seen however, that long training measures often do not show their positive effects until some years later. This requires panel data over a long period of time, which are currently only available for the 1980s and 1990s. For this reason, policy implications about the effectiveness of further training measures should not be drawn on the basis of short-term employment effects alone." (Author's abstract, IAB-Doku) ((en))Weiterbildungsförderung, Beschäftigungseffekte, arbeitsmarktpolitische Maßnahme - Erfolgskontrolle, Trainingsmaßnahme, geschlechtsspezifische Faktoren, Westdeutschland, Ostdeutschland, Bundesrepublik Deutschland

Advances in mapping population and demographic characteristics at small area levels

Temporally and spatially highly resolved information on population characteristics, including demographic profile (e.g. age and sex), ethnicity and socio-economic status (e.g. income, occupation, education), are essential for observational health studies at the small-area level. Time-relevant population data are critical as denominators for health statistics, analytics and epidemiology, to calculate rates or risks of disease. Demographic and socio-economic characteristics are key determinants of health and important confounders in the relationship of environmental contaminants and health. In many countries, census data have long been the source of small-area population denominators and confounder information. A strength of the traditional census model has been its careful design and high level of population coverage, allowing high-quality detailed data to be released for small areas periodically, e.g. every ten years. The timeliness of data, however, becomes a challenge when temporally and spatially highly accurate annual (or even more frequent) data at high spatial resolution 31are needed, for example, for health surveillance and epidemiological studies. Additionally, the approach to collecting demographic population information is changing in the era of openand big data and may eventually evolve to using combinations of administrative and other data, supplemented by surveys. We discuss different approaches to address these challenges including a) the U. S. American Community Survey, a rolling sample of the U.S. population census, b) the use of spatial analysis techniques to compile temporally and spatially high-resolution demographic data, and c) the use of administrative and big data sources as proxies for demographic characteristics

HI distribution and kinematics of NGC 1569

We present WSRT observations of high sensitivity and resolution of the neutral hydrogen in the starburst dwarf galaxy NGC 1569. Assuming a distance of 2.2 Mpc, we find a total HI mass of 1.3 * 10^8 M_sun to be distributed in the form of a dense, clumpy ridge surrounded by more extended diffuse HI containing a few additional discrete features, such as a Western HI Arm and an HI bridge reaching out to a small counterrotating companion cloud. About 10% by mass of all HI in NGC 1569 is at unusually high velocities. Some of this HI may be associated with the mass outflow evident from H-alpha measurements, but some may also be associated with NGC 1569's HI companion and intervening HI bridge, in which case, infall rather than outflow might be the cause of the discrepant velocities. No indication of a large bubble structure was found in position-velocity maps of the high-velocity HI. The galaxy as a whole is in modest overall rotation, but the HI gas lacks any sign of rotation within 60'' (0.6 kpc) from the center, i.e. over most of the optical galaxy. Here, turbulent motions resulting from the starburst appear to dominate over rotation. In the outer disk, the rotational velocities reach a maximum of 35 \pm 6 km/s, but turbulent motion remains significant. Thus, starburst effects are still noticeable in the outer HI disk, although they are no longer dominant beyond 0.6 kpc. Even excluding the most extreme high-velocity HI clouds, NGC 1569 still has an unusually high mean HI velocity dispersion of sigma_v=21.3 km/s, more than double that of other dwarf galaxies.Comment: Figure 11a,b and Figure 14 separately in jpg forma