Effects of oil and natural gas development on territory occupancy of ferruginous hawks and golden eagles in Wyoming, USA

Energy development is expanding rapidly across the western US. Negative effects have been documented for some wildlife, but consequences of development are unclear for other taxa, including raptors. We had the opportunity to examine effects of oil and natural gas development on two raptor species of conservation concern, ferruginous hawks (Buteo regalis) and golden eagles (Aquila chrysaetos), in sagebrush steppe and prairie habitats of Wyoming. We surveyed nest sites of these species using fixed-wing aircraft during 2010–2011, and monitored occupancy of the resulting sample of historically active breeding territories during 2011–2013 for ferruginous hawks, and 2012–2013 for golden eagles. We used single-season occupancy models to evaluate post-construction effects of oil and natural gas development in the context of other factors predicted to influence use of territories by these species, including prey abundance, nest site characteristics, and vegetation. An additional objective was to demonstrate a monitoring protocol for raptors in Wyoming that used probabilistic sampling and accounted for imperfect detection. In support of our predictions, probability of territory occupancy by ferruginous hawks had a strong positive relationship to abundance of ground squirrels (Urocitellus spp.), a strong negative relationship to vegetative cover of sagebrush (Artemisia spp.), and was slightly higher for artificial nest platforms compared to other substrates; and territory occupancy for golden eagles had a strong positive relationship to nest height. Contrary to our predictions, density of oil and natural gas infrastructure was not strongly related to occupancy for either species, and prey abundance was not related to occupancy for golden eagles. The only anthropogenic factor that influenced occupancy for either species was density of improved roads not associated with oil and natural gas fields, which had a weak positive correlation with occupancy for ferruginous hawks, contrary to our predictions. Annual occupancy probability did not vary significantly for either species during our study, but environmental factors associated with occupancy and the strength of relationships varied among years for both species, suggesting occupancy was influenced by additional factors not included in our analysis (e.g. weather, regional dynamics). Detection probability for both species was <1, and strongly influenced by nest substrates. For ferruginous hawks, detection probability varied significantly between years, and was positively associated with nest height. For golden eagles, detection probability was significantly higher in territories with nests on trees, shrubs, and anthropogenic structures, compared to those on cliffs and rock outcrops, with a weak negative trend in detection rates across survey occasions during one year. Our results suggest ferruginous hawks and golden eagles used breeding territories that contained active oil and gas roads and well pads, and density of infrastructure in these territories did not affect their probability of use. However, we advise that limitations of our approach (i.e. post-construction, short-term, observational study) make our results most relevant as a baseline for ongoing monitoring of these species. We suggest protection efforts should be focused on ferruginous hawk territories with abundant ground squirrels and low natural cover of sagebrush, and golden eagle territories with higher nest sites. We recommend conserving populations and habitats of burrowing mammals, mitigating loss of nests using artificial platforms, and long-term monitoring of ferruginous hawks and golden eagles using robust methods that account for imperfect detection

USB: A Unified Summarization Benchmark Across Tasks and Domains

While the NLP community has produced numerous summarization benchmarks, none provide the rich annotations required to simultaneously address many important problems related to control and reliability. We introduce a Wikipedia-derived benchmark, complemented by a rich set of crowd-sourced annotations, that supports $8$ interrelated tasks: (i) extractive summarization; (ii) abstractive summarization; (iii) topic-based summarization; (iv) compressing selected sentences into a one-line summary; (v) surfacing evidence for a summary sentence; (vi) predicting the factual accuracy of a summary sentence; (vii) identifying unsubstantiated spans in a summary sentence; (viii) correcting factual errors in summaries. We compare various methods on this benchmark and discover that on multiple tasks, moderately-sized fine-tuned models consistently outperform much larger few-shot prompted language models. For factuality-related tasks, we also evaluate existing heuristics to create training data and find that training on them results in worse performance than training on $20\times$ less human-labeled data. Our articles draw from $6$ domains, facilitating cross-domain analysis. On some tasks, the amount of training data matters more than the domain where it comes from, while for other tasks training specifically on data from the target domain, even if limited, is more beneficial.Comment: EMNLP Findings 2023 Camera Read

Peri- and postnatal effects of prenatal adenoviral VEGF gene therapy in growth-restricted sheep

Supported by Wellcome Trust project grant 088208 to A.L.D., J.M.W., D.M.P., I.C.Z., and J.F.M. Wellbeing of Women research training fellowship 318 to D.J.C., Scottish Government work package 4.2 to J.M.W., J.S.M., and R.P.A., as well as funding from the National Institute for Health Research University College London Hospitals Biomedical Research Centre A.L.D. and D.M.P., the British Heart Foundation to I.C.Z., and Ark Therapeutics Oy, Kuopio, Finland, which supplied adenovirus vectors free of charge.Peer reviewedPublisher PD

Investigating the physical properties of transiting hot Jupiters with the 1.5-m Kuiper Telescope

We present new photometric data of 11 hot Jupiter transiting exoplanets (CoRoT-12b, HAT-P-5b, HAT-P-12b, HAT-P-33b, HAT-P-37b, WASP-2b, WASP-24b, WASP-60b, WASP-80b, WASP-103b, XO-3b) in order to update their planetary parameters and to constrain information about their atmospheres. These observations of CoRoT-12b, HAT-P-37b and WASP-60b are the first follow-up data since their discovery. Additionally, the first near-UV transits of WASP-80b and WASP-103b are presented. We compare the results of our analysis with previous work to search for transit timing variations (TTVs) and a wavelength dependence in the transit depth. TTVs may be evidence of a third body in the system and variations in planetary radius with wavelength can help constrain the properties of the exoplanet's atmosphere. For WASP-103b and XO-3b, we find a possible variation in the transit depths that may be evidence of scattering in their atmospheres. The B-band transit depth of HAT-P-37b is found to be smaller than its near-IR transit depth and such a variation may indicate TiO/VO absorption. These variations are detected from 2-4.6$\sigma$, so follow-up observations are needed to confirm these results. Additionally, a flat spectrum across optical wavelengths is found for 5 of the planets (HAT-P-5b, HAT-P-12b, WASP-2b, WASP-24b, WASP-80b), suggestive that clouds may be present in their atmospheres. We calculate a refined orbital period and ephemeris for all the targets, which will help with future observations. No TTVs are seen in our analysis with the exception of WASP-80b and follow-up observations are needed to confirm this possible detection.Comment: 18 pages, 7 figures, 9 Tables. Light Curves available online. Accepted to MNRAS (2017 August 25

Human-made structures, vegetation, and weather influence ferruginous hawk breeding performance

Studies of anthropogenic impacts on wildlife may produce inconclusive or biased results if they fail to account for natural sources of variation in breeding performance and do not use probabilistic sampling at a scale functional for management. We used stratified random sampling and generalized linear mixed models to test hypotheses on relationships of daily nest survival rate (DSR) and fledgling production with anthropogenic and environmental factors that influence reproduction in the ferruginous hawk (Buteo regalis). We conducted the study across ferruginous hawk range in Wyoming, USA, 2010–2012. We performed extensive field surveys of prey, vegetation, and nest substrates, and used spatially explicit data to quantify weather, and the most widespread forms of anthropogenic infrastructure (i.e., roads, oil and gas well pads) in ferruginous hawk territories. We found strong evidence that DSR and productivity were greater for nests on anthropogenic structures (i.e., artificial nest platforms, gas condensation tanks, abandoned windmill platforms, power poles) compared to natural substrates (i.e., trees, cliffs, rock outcrops). Additionally, ferruginous hawks produced more fledglings at territories with greater shrub cover and fewer severe storms during the June brood‐rearing period. Amount of oil and gas development and prey was not associated with either measure of breeding performance. Our results suggest that artificial nest platforms are an effective tool to improve breeding success of ferruginous hawks and nesting on anthropogenic structures does not constitute an ecological trap for this species. Although ferruginous hawks nested in some areas with very little vegetative cover, territories with greater amounts of shrub cover produced more fledglings. The negative impact of severe spring storms on fledgling production illustrates the importance of including future weather scenarios in management planning for this species because storms are predicted to increase in frequency and intensity as a result of climate change. Published 2015. This article is a U.S. Government work and is in the public domain in the USA

Re-Occupancy of Breeding Territories by Ferruginous Hawks in Wyoming: Relationships to Environmental and Anthropogenic Factors

Grassland and shrubland birds are declining globally due in part to anthropogenic habitat modification. Because population performance of these species is also influenced by non-anthropogenic factors, it is important to incorporate all relevant ecological drivers into demographic models. We used design-based sampling and occupancy models to test relationships of environmental factors that influence raptor demographics with re-occupancy of breeding territories by ferruginous hawks (Buteo regalis) across Wyoming, USA, 2011-2013. We also tested correlations of territory re-occupancy with oil and gas infrastructure-a leading cause of habitat modification throughout the range of this species of conservation concern. Probability of re-occupancy was not related to any covariates we investigated in 2011, had a strong negative relationship with cover of sagebrush (Artemisia spp.) in 2012, was slightly higher for territories with artificial platforms than other nest substrates in 2013, and had a positive relationship with abundance of ground squirrels (Urocitellus spp.) that was strong in 2012 and weak in 2013. Associations with roads were weak and varied by year, road-type, and scale: in 2012, re-occupancy probability had a weak positive correlation with density of roads not associated with oil and gas fields at the territory-scale; however, in 2013 re-occupancy had a very weak negative correlation with density of oil and gas field roads near nest sites (≤ 500 m). Although our results indicate re-occupancy of breeding territories by ferruginous hawks was compatible with densities of anthropogenic infrastructure in our study area, the lack of relationships between oil and gas well density and territory re-occupancy may have occurred because pre-treatment data were unavailable. We used probabilistic sampling at a broad spatial extent, methods to account for imperfect detection, and conducted extensive prey sampling; nonetheless, future research using before-after-control-impact designs is needed to fully assess impacts of oil and gas development on ferruginous hawks

Examining racial and ethnic disparities in adult emergency department patient visits for concussion in the United States

Background Racial and ethnic differences in emergency department (ED) visits have been reported among adolescent patients but are unsubstantiated among adults. Therefore, our purpose in this study was to examine the relationship between race/ethnicity and adult ED visits for concussions, their injury mechanisms, and computed tomography (CT) scan use among a nationally representative sample. Methods We used the National Hospital Ambulatory Medical Care Survey database from 2010–2015 to examine 63,725 adult (20–45 years old) patient visits, representing an estimated 310.6 million visits presented to EDs. Of these visits, 884 (4.5 million national estimate) were diagnosed with a concussion. Visit records detailed patient information (age, sex, race/ethnicity, geographic region, primary payment type), ED visit diagnoses, injury mechanism (sport, motor vehicle, fall, struck by or against, “other”), and head CT scan use. The primary independent variable was race/ethnicity (non-Hispanic Asian, non-Hispanic Black or African American, Hispanic/Latinx, non-Hispanic multiracial or another, and non-Hispanic White). We used multivariable logistic and multinomial regression models with complex survey sampling design weighting to examine the relationship between concussion ED visits, injury mechanisms, and CT scan use separately by race/ethnicity while accounting for covariates. Results There were no associations between race/ethnicity and concussion diagnosis among adult ED visits after accounting for covariates. Relative to sports-related injuries, non-Hispanic Black or African American patient visits were associated with a motor vehicle (OR = 2.69, 95% CI: 1.06–6.86) and “other” injury mechanism (OR = 4.58, 95% CI: 1.34–15.69) compared to non-Hispanic White patients. Relative to sports-related injuries, non-Hispanic Asian, multiracial, or patients of another race had decreased odds of falls (OR = 0.20, 95% CI: 0.04–0.91) and “other” injuries (OR = 0.09, 95% CI: 0.01–0.55) compared to non-Hispanic White patients. The odds of a CT scan being performed were significantly lower among Hispanic/Latinx patient visits relative to non-Hispanic White patients (OR = 0.52, 95% CI: 0.30–0.91), while no other race/ethnicity comparisons differed. Conclusion Our findings indicate that the overarching concussion ED visit likelihood may not differ by race/ethnicity in adults, but the underlying mechanism causing the concussion and receiving a CT scan demonstrates considerable differences. Prospective future research is warranted to comprehensively understand and intervene in the complex, multi-level race/ethnicity relationships related to concussion health care to ensure equitable patient treatment

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44.

Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating&nbsp;levels of BCAA are linked to obesity and diabetes. The mechanisms of this paradox remain unclear. Here we report that, on cold exposure, brown adipose tissue (BAT) actively utilizes BCAA in the mitochondria for thermogenesis and promotes systemic BCAA clearance in mice and humans. In turn, a BAT-specific defect in BCAA catabolism attenuates systemic BCAA clearance, BAT fuel oxidation and thermogenesis, leading to diet-induced obesity and glucose intolerance. Mechanistically, active BCAA catabolism in BAT is mediated by SLC25A44, which transports BCAAs into mitochondria. Our results suggest that BAT serves as a key metabolic filter that controls BCAA clearance via SLC25A44, thereby contributing to the improvement of metabolic health

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

The endoplasmic reticulum (ER) is a highly dynamic network of membranes. Here, we combine live-cell microscopy with in situ cryo–electron tomography to directly visualize ER dynamics in several secretory cell types including pancreatic β-cells and neurons under near-native conditions. Using these imaging approaches, we identify a novel, mobile form of ER, ribosome-associated vesicles (RAVs), found primarily in the cell periphery, which is conserved across different cell types and species. We show that RAVs exist as distinct, highly dynamic structures separate from the intact ER reticular architecture that interact with mitochondria via direct intermembrane contacts. These findings describe a new ER subcompartment within cells