Equation of state of cubic boron nitride at high pressures and temperatures

We report accurate measurements of the equation of state (EOS) of cubic boron nitride by x-ray diffraction up to 160 GPa at 295 K and 80 GPa in the range 500-900 K. Experiments were performed on single-crystals embedded in a quasi-hydrostatic pressure medium (helium or neon). Comparison between the present EOS data at 295 K and literature allows us to critically review the recent calibrations of the ruby standard. The full P-V-T data set can be represented by a Mie-Gr\"{u}neisen model, which enables us to extract all relevant thermodynamic parameters: bulk modulus and its first pressure-derivative, thermal expansion coefficient, thermal Gr\"{u}neisen parameter and its volume dependence. This equation of state is used to determine the isothermal Gr\"{u}neisen mode parameter of the Raman TO band. A new formulation of the pressure scale based on this Raman mode, using physically-constrained parameters, is deduced.Comment: 8 pages, 7 figure

Analysis of the Effects of Inhaled Diesel Exhaust on the Alveolar Intravascular and Interstitial Cellular Components of Rodent Lungs

Transmission electron microscopy (TEM) was used to determine the effect of diesel engine exhaust (DEE) on the intravascular and interstitial cellular population of the lungs of exposed rats and guinea pigs. Animals with matched controls were subjected to environments of either 250, 750, 1500 or 6000 μg/m3 for either 2 weeks, 6 weeks, 10 weeks or 18 months. These animals were sacrificed immediately following the exposure periods and their lungs perfused with fixative. Following dissection, random stratified biopsies from the lungs of these animals were made. Ultrathin sections from the alveolar lung were prepared and conventionally processed for TEM and randomly photographed to compose a micrograph database. These micrographs were analyzed by point counting using a Zeiss MOP 3 Digital Image Analyzer. The results indicated no significant intravascular cellular response but a significant increase in the mononuclear population in the interstitium

Conserved currents of massless fields of spin s>0

A complete and explicit classification of all locally constructed conserved currents and underlying conserved tensors is obtained for massless linear symmetric spinor fields of any spin s>0 in four dimensional flat spacetime. These results generalize the recent classification in the spin s=1 case of all conserved currents locally constructed from the electromagnetic spinor field. The present classification yields spin s>0 analogs of the well-known electromagnetic stress-energy tensor and Lipkin's zilch tensor, as well as a spin s>0 analog of a novel chiral tensor found in the spin s=1 case. The chiral tensor possesses odd parity under a duality symmetry (i.e., a phase rotation) on the spin s field, in contrast to the even parity of the stress-energy and zilch tensors. As a main result, it is shown that every locally constructed conserved current for each s>0 is equivalent to a sum of elementary linear conserved currents, quadratic conserved currents associated to the stress-energy, zilch, and chiral tensors, and higher derivative extensions of these currents in which the spin s field is replaced by its repeated conformally-weighted Lie derivatives with respect to conformal Killing vectors of flat spacetime. Moreover, all of the currents have a direct, unified characterization in terms of Killing spinors. The cases s=2, s=1/2 and s=3/2 provide a complete set of conserved quantities for propagation of gravitons (i.e., linearized gravity waves), neutrinos and gravitinos, respectively, on flat spacetime. The physical meaning of the zilch and chiral quantities is discussed.Comment: 26 pages; final version with minor changes, accepted in Proc. Roy. Soc. A (London

Preparedness for use of the rapid result HIV self-test by gay men and other men who have sex with men (MSM): a mixed methods exploratory study among MSM and those involved in HIV prevention and care

Objectives: The aim of the study was to explore preparedness for the HIV self-test among men who have sex with men (MSM) and those involved in HIV prevention and care. Methods: A mixed methods exploratory research design was employed, detailing awareness and willingness to use the self-test and the perceived barriers and facilitators to implementation. Quantitative and qualitative data collection and analysis were completed in parallel. Descriptive and inferential analysis of cross-sectional bar-based survey data collected from MSM through a self-completed questionnaire and oral fluid specimen collection (n = 999) was combined with qualitative, thematic, analysis of data collected through 12 expert focus groups (n = 55) consisting of gay men, National Health Service (NHS) staff, community organizations, entrepreneurs and activists. Findings were subsequently combined and assessed for synergies. Results: Among MSM, self-test awareness was moderate (55%). Greater awareness was associated with increased educational attainment [adjusted odds ratio 1.51; 95% confidence interval (CI) 1.00–2.30; P = 0.05] and previous history of sexually transmitted infection (STI) testing (adjusted odds ratio 1.63; 95% CI 1.11–2.39; P = 0.01). Willingness to use the test was high (89%) and associated with meeting sexual partners online (unadjusted odds ratio 1.96; 95% CI 1.31–2.94; P < 0.001). Experts highlighted the overall acceptability of self-testing; it was understood as convenient, discreet, accessible, and with a low burden to services. However, some ambivalence towards self-testing was reported; it could reduce opportunities to engage with wider services, wider health issues and the determinants of risk. Conclusions: Self-testing represents an opportunity to reduce barriers to HIV testing and enhance prevention and access to care. Levels of awareness are moderate but willingness to use is high. Self-testing may amplify health inequalities