Quantum magnetism with ultracold molecules

This article gives an introduction to the realization of effective quantum magnetism with ultracold molecules in an optical lattice, reviews experimental and theoretical progress, and highlights future opportunities opened up by ongoing experiments. Ultracold molecules offer capabilities that are otherwise difficult or impossible to achieve in other effective spin systems, such as long-ranged spin-spin interactions with controllable degrees of spatial and spin anisotropy and favorable energy scales. Realizing quantum magnetism with ultracold molecules provides access to rich many-body behaviors, including many exotic phases of matter and interesting excitations and dynamics. Far-from-equilibrium dynamics plays a key role in our exposition, just as it did in recent ultracold molecule experiments realizing effective quantum magnetism. In particular, we show that dynamical probes allow the observation of correlated many-body spin physics, even in polar molecule gases that are not quantum degenerate. After describing how quantum magnetism arises in ultracold molecules and discussing recent observations of quantum magnetism with polar molecules, we survey prospects for the future, ranging from immediate goals to long-term visions.Comment: 21 pages, 6 figures, 1 table. Review articl

Automated clinical system for chromosome analysis

An automatic chromosome analysis system is provided wherein a suitably prepared slide with chromosome spreads thereon is placed on the stage of an automated microscope. The automated microscope stage is computer operated to move the slide to enable detection of chromosome spreads on the slide. The X and Y location of each chromosome spread that is detected is stored. The computer measures the chromosomes in a spread, classifies them by group or by type and also prepares a digital karyotype image. The computer system can also prepare a patient report summarizing the result of the analysis and listing suspected abnormalities

RnaseIII and T4 Polynucleotide Kinase Sequence Biases and Solutions During RNA-Seq Library Construction

Background: RNA-seq is a next generation sequencing method with a wide range of applications including single nucleotide polymorphism (SNP) detection, splice junction identification, and gene expression level measurement. However, the RNA-seq sequence data can be biased during library constructions resulting in incorrect data for SNP, splice junction, and gene expression studies. Here, we developed new library preparation methods to limit such biases. Results: A whole transcriptome library prepared for the SOLiD system displayed numerous read duplications (pile-ups) and gaps in known exons. The pile-ups and gaps of the whole transcriptome library caused a loss of SNP and splice junction information and reduced the quality of gene expression results. Further, we found clear sequence biases for both 5' and 3' end reads in the whole transcriptome library. To remove this bias, RNaseIII fragmentation was replaced with heat fragmentation. For adaptor ligation, T4 Polynucleotide Kinase (T4PNK) was used following heat fragmentation. However, its kinase and phosphatase activities introduced additional sequence biases. To minimize them, we used OptiKinase before T4PNK. Our study further revealed the specific target sequences of RNaseIII and T4PNK. Conclusions: Our results suggest that the heat fragmentation removed the RNaseIII sequence bias and significantly reduced the pile-ups and gaps. OptiKinase minimized the T4PNK sequence biases and removed most of the remaining pile-ups and gaps, thus maximizing the quality of RNA-seq data.National Institute on Alcohol Abuse and Alcoholism (NIAAA) AA12404, AA019382, AA020926, AA016648National Institutes of Health (NIH) R01 GM088344Waggoner Center for Alcohol and Addiction Researc

Effectiveness of slow motion video compared to real time video in improving the accuracy and consistency of subjective gait analysis in dogs

Objective measures of canine gait quality via force plates, pressure mats or kinematic analysis are considered superior to subjective gait assessment (SGA). Despite research demonstrating that SGA does not accurately detect subtle lameness, it remains the most commonly performed diagnostic test for detecting lameness in dogs. This is largely because the financial, temporal and spatial requirements for existing objective gait analysis equipment makes this technology impractical for use in general practice. The utility of slow motion video as a potential tool to augment SGA is currently untested. To evaluate a more accessible way to overcome the limitations of SGA, a slow motion video study was undertaken. Three experienced veterinarians reviewed video footage of 30 dogs, 15 with a diagnosis of primary limb lameness based on history and physical examination, and 15 with no indication of limb lameness based on history and physical examination. Four different videos were made for each dog, demonstrating each dog walking and trotting in real time, and then again walking and trotting in 50% slow motion. For each video, the veterinary raters assessed both the degree of lameness, and which limb(s) they felt represented the source of the lameness. Spearman’s rho, Cramer’s V, and t-tests were performed to determine if slow motion video increased either the accuracy or consistency of raters’ SGA relative to real time video. Raters demonstrated no significant increase in consistency or accuracy in their SGA of slow motion video relative to real time video. Based on these findings, slow motion video does not increase the consistency or accuracy of SGA values. Further research is required to determine if slow motion video will benefit SGA in other ways

Model projects as tools for cooperative urban development: The case of Haus der Statistik in Berlin

According to the New Leipzig Charter, urban development processes should be ‘a matter of all’ – the common good, climate protection and environmental justice, to name but a few aspects. Currently, new forms of innovation seeking models emerge within this context of sustainable urban planning practice - for example, real-world field laboratories and model projects. Haus der Statistik in Berlin is one such ‘model project for cooperative and common-good-oriented urban development’. It is widely recognized for its demand- and process-driven approach, as well as its project development being based on public-civic partnership. As anthropological and urbanist researchers and practitioners involved in the project, we give a situated account on the socio-political elements of the Haus der Statistik’s public-civic partnership and investigate the potentials of this model for a more sustainable urban development. The structure of the paper is threefold: Firstly, we introduce the so-called model project Haus der Statistik and its common-good orientated agenda and relate it to sustainability goals of the New Leipzig Charter. Secondly, we introduce the specific public-civic-framework in regard to its methodological framing within the context of model projects and comparable approaches that focus on collaborative, transdisciplinary and innovative methods, such as real-world field laboratories. Thirdly, we reflect on the elements of the public-civic-partnership framework that have been explored and developed at the ‘model project’ Haus der Statistik since 2015 and its implications for a more sustainable urban development.Peer Reviewe

Advanced flight control system study

A fly by wire flight control system architecture designed for high reliability includes spare sensor and computer elements to permit safe dispatch with failed elements, thereby reducing unscheduled maintenance. A methodology capable of demonstrating that the architecture does achieve the predicted performance characteristics consists of a hierarchy of activities ranging from analytical calculations of system reliability and formal methods of software verification to iron bird testing followed by flight evaluation. Interfacing this architecture to the Lockheed S-3A aircraft for flight test is discussed. This testbed vehicle can be expanded to support flight experiments in advanced aerodynamics, electromechanical actuators, secondary power systems, flight management, new displays, and air traffic control concepts

Structure of protease-cleaved escherichia coliα-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment

Bacterial -2-macroglobulins have been suggested to function in defence as broad-spectrum inhibitors of host proteases that breach the outer membrane. Here, the X-ray structure of protease-cleaved Escherichia coli -2-macroglobulin is described, which reveals a putative mechanism of activation and conformational change essential for protease inhibition. In this competitive mechanism, protease cleavage of the bait-region domain results in the untethering of an intrinsically disordered region of this domain which disrupts native interdomain interactions that maintain E. coli -2-macroglobulin in the inactivated form. The resulting global conformational change results in entrapment of the protease and activation of the thioester bond that covalently links to the attacking protease. Owing to the similarity in structure and domain architecture of Escherichia coli -2-macroglobulin and human -2-macro­globulin, this protease-activation mechanism is likely to operate across the diverse members of this group

[OII] Emission, Eigenvector 1 and Orientation in Radio-quiet Quasars

We present supportive evidence that the Boroson and Green eigenvector 1 is not driven by source orientation. Until recently it was generally accepted that eigenvector 1 does not depend on orientation as it strongly correlates with [OIII]5007 emission, thought to be an isotropic property. However, recent studies of radio-loud AGN have questioned the isotropy of [OIII] emission and concluded that [OII]3727 emission is isotropic. In this paper we investigate the relation between eigenvector 1 and [OII] emission in radio-quiet BQS (Bright Quasar Survey) quasars, and readdress the issue of orientation as the driver of eigenvector 1. We find significant correlations between eigenvector 1 and orientation independent [OII] emission, which implies that orientation does not drive eigenvector 1. The luminosities and equivalent widths of [OIII] and [OII] correlate with one another, and the range in luminosities and equivalent widths is similar. This suggests that the radio-quiet BQS quasars are largely free of orientation dependent dust effects and ionization dependent effects in the narrow-line region. We also conclude that neither the [OIII] emission nor the [OII]/[OIII] ratio are dependent on orientation in our radio-quiet BQS quasar sample, contrary to recent results found for radio-loud quasars.Comment: 24 pages, 12 figures, accepted for publication in Ap

Prospects of searches for long-lived charged particles with MoEDAL

We study the prospects of searches for exotic long-lived particles with the MoEDAL detector at the LHC, assuming the integrated luminosity of 30 fb$^{-1}$ that is expected at the end of Run 3. MoEDAL incorporates nuclear track detectors deployed a few metres away from the interaction point, which are sensitive to any highly-ionizing particles. Hence MoEDAL is able to detect singly- or doubly-charged particles with low velocities $\beta < 0.15$ or $< 0.3$, respectively, and lifetimes larger than ${\cal O}(1) \,{\rm m}/c$. We examine the MoEDAL sensitivity to various singly-charged supersymmetric particles with long lifetimes and to several types of doubly-charged long-lived particles with different spins and SU(2) charges. We compare the prospective MoEDAL mass reaches to current limits from ATLAS and CMS, which involve auxiliary analysis assumptions. MoEDAL searches for doubly-charged fermions are particularly competitive.Comment: 19 pages, 5 figure