Southwest Research Institute assistance to NASA in biomedical areas of the technology utilization program Quarterly progress report, 1 May - 31 Jul. 1969

Dissemination of NASA derived technologies for biomedical applicatio

Prospects of searches for long-lived charged particles with MoEDAL

We study the prospects of searches for exotic long-lived particles with the MoEDAL detector at the LHC, assuming the integrated luminosity of 30 fb$^{-1}$ that is expected at the end of Run 3. MoEDAL incorporates nuclear track detectors deployed a few metres away from the interaction point, which are sensitive to any highly-ionizing particles. Hence MoEDAL is able to detect singly- or doubly-charged particles with low velocities $\beta < 0.15$ or $< 0.3$, respectively, and lifetimes larger than ${\cal O}(1) \,{\rm m}/c$. We examine the MoEDAL sensitivity to various singly-charged supersymmetric particles with long lifetimes and to several types of doubly-charged long-lived particles with different spins and SU(2) charges. We compare the prospective MoEDAL mass reaches to current limits from ATLAS and CMS, which involve auxiliary analysis assumptions. MoEDAL searches for doubly-charged fermions are particularly competitive.Comment: 19 pages, 5 figure

Salmonella Pathogenesis and Processing of Secreted Effectors by Caspase-3

The enteric pathogen Salmonella enterica serovar Typhimurium causes food poisoning resulting in gastroenteritis. The S. Typhimurium effector Salmonella invasion protein A (SipA) promotes gastroenteritis by functional motifs that trigger either mechanisms of inflammation or bacterial entry. During infection of intestinal epithelial cells, SipA was found to be responsible for the early activation of caspase-3, an enzyme that is required for SipA cleavage at a specific recognition motif that divided the protein into its two functional domains and activated SipA in a manner necessary for pathogenicity. Other caspase-3 cleavage sites identified in S. Typhimurium appeared to be restricted to secreted effector proteins, which indicates that this may be a general strategy used by this pathogen for processing of its secreted effectors

Enemies Within: Redefining the insider threat in organizational security policy

The critical importance of electronic information exchanges in the daily operation of most large modern organizations is causing them to broaden their security provision to include the custodians of exchanged data – the insiders. The prevailing data loss threat model mainly focuses upon the criminal outsider and mainly regards the insider threat as ‘outsiders by proxy’, thus shaping the relationship between the worker and workplace in information security policy. A policy that increasingly takes the form of social policy for the information age as it acquires the power to include and exclude sections of society and potentially to re-stratify it? This article draws upon empirical sources to critically explore the insider threat in organizations. It looks at the prevailing threat model before deconstructing ‘the insider’ into various risk profiles, including the well-meaning insider, before drawing conclusions about what the building blocks of information security policy around the insider might be

Explicit Model Realizing Parton-Hadron Duality

We present a model that realizes both resonance-Regge (Veneziano) and parton-hadron (Bloom-Gilman) duality. We first review the features of the Veneziano model and we discuss how parton-hadron duality appears in the Bloom-Gilman model. Then we review limitations of the Veneziano model, namely that the zero-width resonances in the Veneziano model violate unitarity and Mandelstam analyticity. We discuss how such problems are alleviated in models that construct dual amplitudes with Mandelstam analyticity (so-called DAMA models). We then introduce a modified DAMA model, and we discuss its properties. We present a pedagogical model for dual amplitudes and we construct the nucleon structure function F2(x,Q2). We explicitly show that the resulting structure function realizes both Veneziano and Bloom-Gilman duality.Comment: 11 pages, 8 figure