Factors related to the emotional responses of rural school-aged children who have asthma

textAsthma is a complex, chronic disorder of the airways that is characterized by underlying inflammation, airflow obstruction, and bronchial hyperresponsiveness. Asthma symptoms can be frightening and can have an effect on the emotional functioning Quality of Life (QOL) of school-aged children who have asthma. The purpose of this exploratory, descriptive, cross-sectional, correlational study was to explore the influence of factors identified in the literature on school-aged children’s emotional responses to asthma. Guiding this study was a theoretical model that proposed that the impact of chronic illness severity on QOL is potentially mediated by both resource and barrier factors. The population of interest was 85 school-aged children (ages 6-12) and parents of children who have asthma that were recruited from participants already enrolled in year 4 of the Asthma in Central Texas (ACT) study (R01NR007770, Sharon D. Horner, P.I.) at The University of Texas at Austin. Significant inverse correlations were found between asthma related child emotional functioning QOL and each of the following variables: asthma severity, r = -.30, p < .01; child internalizing behaviors, r = -.26, p < .05, and child externalizing behaviors, r = -.43, p < .001. Significant inverse relationships were found between caregiver emotional functioning QOL and each of the following variables: asthma severity, r = -.39, p < .001; child internalizing behaviors, r = -.22, p < .05 and child externalizing behaviors, r = -.25, p < .05. Multiple regression analysis revealed that asthma severity and child externalizing problems accounted for 26% of the variance in child emotional functioning QOL. No moderators or mediators were identified. Findings from this study imply that externalizing problem behaviors of school-aged children may be a predictor of their negative feelings about their asthma. Nursing educators should consider including the emotional impact of asthma on children in nursing curriculums as this may ultimately influence health care providers to more skillfully address this important issue in both assessment and intervention settings.Nursin

What\u27s Your Research Personality? A New Way of Engaging Students in Resource and Service Discovery Through a Homegrown Quiz App

How can libraries push resource and service information to students in engaging ways? Influenced by social media personality quizzes, we designed a questionnaire-style app that uses learning preferences and personality traits to connect students with the library resources they need most. This LOEX 2022 session will demonstrate how libraries can use innovative approaches with their existing resources to draw students in. We will use our Research Personality Quiz as a starting point to discuss design approaches for similar projects and explore the technical challenges that may be encountered (and overcome) in creating and launching similar types of quiz apps. Participants will: Learn about personality research and how it can provide a different approach to defining user groups and needs. Be able to apply an approach to align their library\u27s existing resources and services to student personality traits. Understand how academic libraries can use existing technology to push content more proactively to students

Extended-Service Schools: Putting Programming in Place

Spurred by the desire to provide youth with safe havens in non-school hours, enhanced educational experiences, and other developmental opportunities, a movement to open up schools has taken root in cities across the country. More than just an attempt to take advantage of schools' resources and facilities, the movement aims to build a new kind of institution -- one that unites schools and community-based organizations to create vital centers of activity for children, youth, and their families. This interim evaluation report of the Wallace-Readers Digest Funds Extended-Service Schools Adaptation examines what it takes to get a community-oriented school-based youth program off the ground, the early challenges that can be expected, and how the ESS sites addressed their challenges

The Curious Case of the Steamship on the Mekong

Painted and engraved rock art appear at the Pak Ou caves, a complex of caverns containing Buddhist offerings and shrines located at the confluence of two rivers in Luang Prabang Province, Lao PDR. Faded red paintings and writing can be found on the cliff face housing the lower cave, colloquially known as the “Cave of a Thousand Buddhas,” while in the upper cave, red anthropomorphs and flowers along with black anthropomorphic figures are painted on the walls. This red and black rock art may predate the Buddhist use of the cave. However, one painting found in the upper cave 10 m from the entrance is unusual as it utilizes a green pigment, and resembles modern steamships that might have transited the upper Mekong. This article considers the historic context of the cave and significance of this Laotian rock art site, which has received little attention in academic literature thus far. Because boat imagery in rock art is not unheard of in Southeast Asia, we hope to highlight the potential for this art to illuminate episodes from the recent past

Multiple Choices After School: Findings from the Extended-Service Schools Initiative

In the summer of 2002, every state became eligible to receive federal funds for after-school programs. With this opportunity came the need to make decisions about the goals, design and content of after-school programming -- decisions that will influence which youth participate, what they experience and how they may benefit. This report aims to put policymakers and program operators on firmer ground as they grapple with these decisions; it shares lessons from existing school-based after-school programs

An Exploration of “Down by the Water” As a Conceptual Framework of Place

Peer reviewe

The evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains

Background: The Q151M multi-drug resistance (MDR) pathway in HIV-1 reverse transcriptase (RT) confers reduced susceptibility to all nucleoside reverse transcriptase inhibitors (NRTIs) excluding tenofovir (TDF). This pathway emerges after long term failure of therapy, and is increasingly observed in the resource poor world, where antiretroviral therapy is rarely accompanied by intensive virological monitoring. In this study we examined the genotypic, phenotypic and fitness correlates associated with the development of Q151M MDR in the absence of viral load monitoring.Results: Single-genome sequencing (SGS) of full-length RT was carried out on sequential samples from an HIV-infected individual enrolled in ART rollout. The emergence of Q151M MDR occurred in the order A62V, V75I, and finally Q151M on the same genome at 4, 17 and 37 months after initiation of therapy, respectively. This was accompanied by a parallel cumulative acquisition of mutations at 20 other codon positions; seven of which were located in the connection subdomain. We established that fourteen of these mutations are also observed in Q151M-containing sequences submitted to the Stanford University HIV database. Phenotypic drug susceptibility testing demonstrated that the Q151M-containing RT had reduced susceptibility to all NRTIs except for TDF. RT domain-swapping of patient and wild-type RTs showed that patient-derived connection subdomains were not associated with reduced NRTI susceptibility. However, the virus expressing patient-derived Q151M RT at 37 months demonstrated similar to 44% replicative capacity of that at 4 months. This was further reduced to similar to 22% when the Q151M-containing DNA pol domain was expressed with wild-type C-terminal domain, but was then fully compensated by coexpression of the coevolved connection subdomain.Conclusions: We demonstrate a complex interplay between drug susceptibility and replicative fitness in the acquisition Q151M MDR with serious implications for second-line regimen options. The acquisition of the Q151M pathway occurred sequentially over a long period of failing NRTI therapy, and was associated with mutations in multiple RT domains