Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies

Date of Acceptance: 23/07/2015 We thank Gillian Milne for help with electron microscopy, Sophie M. Schäfer for pilot experiments, and Emilia Mellado for strains. All authors acknowledge financial support of Gilead Sciences through Ph.D. studentships for L.A.W. and K.K.L. We also acknowledge research grants from the Wellcome Trust (080088, 086827, 075470, 099215, and 097377) and the British Society for Antimicrobial Chemotherapy.Peer reviewedPublisher PD

Oxidative Heck desymmetrisation of 2,2-disubstituted cyclopentene-1,3-diones

Oxidative Heck couplings have been successfully developed for 2,2-disubstituted cyclopentene-1,3-diones. The direct coupling onto the 2,2-disubstituted cyclopentene-1,3-dione core provides a novel expedient way of enantioselectively desymmetrising all-carbon quaternary centres

Empirical relations for cluster RR Lyrae stars revisited

Our former study on the empirical relations between the Fourier parameters of the light curves of the fundamental mode RR Lyrae stars and their basic stellar parameters has been extended to considerably larger data sets. The most significant contribution to the absolute magnitude M_v comes from the period P and from the first Fourier amplitude A_1, but there are statistically significant contributions also from additional higher order components, most importantly from A_3 and in a lesser degree from the Fourier phase phi_51. When different colors are combined in reddening-free quantities, we obtain basically period-luminosity-color relations. Due to the log T_eff (B-V, log g, [Fe/H]) relation from stellar atmosphere models, we would expect some dependence also on phi_31. Unfortunately, the data are still not extensive and accurate enough to decipher clearly the small effect of this Fourier phase. However, with the aid of more accurate multicolor data on field variables, we show that this Fourier phase should be present either in V-I or in B-V or in both. From the standard deviations of the various regressions, an upper limit can be obtained on the overall inhomogeneity of the reddening in the individual clusters. This yields sigma_E(B-V)}< 0.012 mag, which also implies an average minimum observational error of sigma_V > 0.018 mag.Comment: 14 pages, 11 figures, 11 tables, accepted in Astronomy & Astrophysic

Low-Threshold Electrically Pumps Vertical-Cavity Surface-Emitting Microlasers

Vertical-cavity electrically driven lasers with three GaInAs quantum wells and diameters of several μm exhibit room-temperature pulsed current thresholds as low as 1.3mA with 958 nm output wavelength

Development and Validation of eRADAR: A Tool Using EHR Data to Detect Unrecognized Dementia.

ObjectivesEarly recognition of dementia would allow patients and their families to receive care earlier in the disease process, potentially improving care management and patient outcomes, yet nearly half of patients with dementia are undiagnosed. Our aim was to develop and validate an electronic health record (EHR)-based tool to help detect patients with unrecognized dementia (EHR Risk of Alzheimer's and Dementia Assessment Rule [eRADAR]).DesignRetrospective cohort study.SettingKaiser Permanente Washington (KPWA), an integrated healthcare delivery system.ParticipantsA total of 16 665 visits among 4330 participants in the Adult Changes in Thought (ACT) study, who undergo a comprehensive process to detect and diagnose dementia every 2 years and have linked KPWA EHR data, divided into development (70%) and validation (30%) samples.MeasurementsEHR predictors included demographics, medical diagnoses, vital signs, healthcare utilization, and medications within the previous 2 years. Unrecognized dementia was defined as detection in ACT before documentation in the KPWA EHR (ie, lack of dementia or memory loss diagnosis codes or dementia medication fills).ResultsOverall, 1015 ACT visits resulted in a diagnosis of incident dementia, of which 498 (49%) were unrecognized in the KPWA EHR. The final 31-predictor model included markers of dementia-related symptoms (eg, psychosis diagnoses, antidepressant fills), healthcare utilization pattern (eg, emergency department visits), and dementia risk factors (eg, cerebrovascular disease, diabetes). Discrimination was good in the development (C statistic = .78; 95% confidence interval [CI] = .76-.81) and validation (C statistic = .81; 95% CI = .78-.84) samples, and calibration was good based on plots of predicted vs observed risk. If patients with scores in the top 5% were flagged for additional evaluation, we estimate that 1 in 6 would have dementia.ConclusionThe eRADAR tool uses existing EHR data to detect patients with good accuracy who may have unrecognized dementia. J Am Geriatr Soc 68:103-111, 2019

Molecular Line Emission from Gravitationally Unstable Protoplanetary Disks

In the era of high resolution submillimeter interferometers, it will soon be possible to observe the neutral circumstellar medium directly involved in gas giant planet (GGP) formation at physical scales previously unattainable. In order to explore possible signatures of gas giant planet formation via disk instabilities, we have combined a 3D, non-local thermodynamic equilibrium (LTE) radiative transfer code with a 3D, finite differences hydrodynamical code to model molecular emission lines from the vicinity of a 1.4 M_J self-gravitating proto-GGP. Here, we explore the properties of rotational transitions of the commonly observed dense gas tracer, HCO+. Our main results are the following: 1. Very high lying HCO+ transitions (e.g. HCO+ J=7-6) can trace dense planet forming clumps around circumstellar disks. Depending on the molecular abundance, the proto-GGP may be directly imageable by the Atacama Large Millimeter Array (ALMA). 2. HCO+ emission lines are heavily self-absorbed through the proto-GGP's dense molecular core. This signature is nearly ubiquitous, and only weakly dependent on assumed HCO+ abundances. The self-absorption features are most pronounced at higher angular resolutions. Dense clumps that are not self-gravitating only show minor self-absorption features. 3. Line temperatures are highest through the proto-GGP at all assumed abundances and inclination angles. Conversely, due to self-absorption in the line, the velocity-integrated intensity may not be. High angular resolution interferometers such as the Submillimeter Array (SMA) and ALMA may be able to differentiate between competing theories of gas giant planet formation.Comment: 10 pages, 13 figures; Accepted by Ap

Multiple Stellar Populations in the Globular Cluster omega Centauri as Tracers of a Merger Event

The discovery of the Sagittarius dwarf galaxy, which is being tidally disrupted by and merging with the Milky Way, supports the view that the halo of the Galaxy has been built up at least partially by the accretion of similar dwarf systems. The Sagittarius dwarf contains several distinct populations of stars, and includes M54 as its nucleus, which is the second most massive globular cluster associated with the Milky Way. The most massive globular cluster is omega Centauri, and here we report that omega Centauri also has several distinct stellar populations, as traced by red-giant-branch stars. The most metal-rich red-giant-branch stars are about 2 Gyr younger than the dominant metal-poor component, indicating that omega Centauri was enriched over this timescale. The presence of more than one epoch of star formation in a globular cluster is quite surprising, and suggests that omega Centauri was once part of a more massive system that merged with the Milky Way, as the Sagittarius dwarf galaxy is in the process of doing now. Mergers probably were much more frequent in the early history of the Galaxy and omega Centauri appears to be a relict of this era.Comment: 7 pages, 3 figures, Latex+nature.sty (included), To appear in November 4th issue of Natur

Automated verification of shape and size properties via separation logic.

Despite their popularity and importance, pointer-based programs remain a major challenge for program verification. In this paper, we propose an automated verification system that is concise, precise and expressive for ensuring the safety of pointer-based programs. Our approach uses user-definable shape predicates to allow programmers to describe a wide range of data structures with their associated size properties. To support automatic verification, we design a new entailment checking procedure that can handle well-founded inductive predicates using unfold/fold reasoning. We have proven the soundness and termination of our verification system, and have built a prototype system

Microwave Conductivity due to Scattering from Extended Linear Defects in d-Wave Superconductors

Recent microwave conductivity measurements of detwinned, high-purity, slightly overdoped YBa$_{2}$Cu$_{3}$O$_{6.993}$ crystals reveal a linear temperature dependence and a near-Drude lineshape for temperatures between 1 and 20 K and frequencies ranging from 1 to 75 GHz. Prior theoretical work has shown that simple models of scattering by point defects (impurities) in d-wave superconductors are inconsistent with these results. It has therefore been suggested that scattering by extended defects such as twin boundary remnants, left over from the detwinning process, may also be important. We calculate the self-energy and microwave conductivity in the self-consistent Born approximation (including vertex corrections) for a d-wave superconductor in the presence of scattering from extended linear defects. We find that in the experimentally relevant limit ($\Omega, 1/\tau \ll T \ll \Delta_{0}$), the resulting microwave conductivity has a linear temperature dependence and a near-Drude frequency dependence that agrees well with experiment.Comment: 13 pages, 7 figure