1,635 research outputs found
Scratching beneath the surface : how organisational culture influences curricular reform
Funding information: This work was supported by the Royal College of Surgeons of Edinburgh [Grant number RG-15026]. ACKNOWLEDGEMENTS We would like to thank Graham Haddock, Satheesh Yalamarthi and Mark Vella for their assistance with participant recruitment, and all the surgical trainees and trainers who took part in the study.Peer reviewedPublisher PD
It's making me think outside the box at times : a qualitative study of dynamic capabilities in surgical training.
Acknowledgements The authors would like to thank Graham Haddock, Satheesh Yalamarthi, and Mark Vella for their assistance with participant recruitment. Funding Information: This work was supported by the Royal College of Surgeons of Edinburgh [Grant number RG-15026].Peer reviewedPublisher PD
Forestry Bulletin No. 25: Silviculture of Southern Bottomland Hardwoods
The potential of southern bottomland hardwood types is clear, for they, along with the cypress, occupy about 37 million acres and compromise more than half of the hardwood stumpage in the south.https://scholarworks.sfasu.edu/forestrybulletins/1021/thumbnail.jp
Scotland's "Incentivised Laparoscopy Practice" programme:Engaging trainees with take-home laparoscopy simulation
Incorporating temporal and spatial variability of salt-marsh foraminifera into sea-level reconstructions
Foraminifera from salt-marsh environments have been used extensively in quantitative relative sea-level reconstructions due to their strong relationship with tidal level. However, the influence of temporal and spatial variability of salt-marsh foraminifera on quantitative reconstructions remains unconstrained. Here, we conducted a monitoring study of foraminifera from four intertidal monitoring stations in New Jersey from high marsh environments over three years that included several extreme weather (temperature, precipitation, and storm surge) events. We sampled four replicates from each station seasonally (four times per year) for a total of 188 samples. The dead foraminiferal assemblages were separated into four site-specific assemblages. After accounting for systematic trends in changes in foraminifera over time among stations, the distribution of foraminiferal assemblages across monitoring stations explained ~87% of the remaining variation, while ~13% can be explained by temporal and/or spatial variability among the replicate samples. We applied a Bayesian transfer function to estimate the elevation of the four monitoring stations. All samples from each station predicted an elevation estimate within a 95% uncertainty interval consistent with the observed elevation of that station. Combining samples into replicate- and seasonal-aggregate datasets decreased elevation estimate uncertainty, with the greatest decrease in aggregate datasets from Fall and Winter. Information about the temporal and spatial variability of modern foraminiferal distributions was formally incorporated into the Bayesian transfer function through informative foraminifera variability priors and was applied to a Common Era relative sea-level record in New Jersey. The average difference in paleomarsh elevation estimates and uncertainties using an informative vs uninformative prior was minimal
Barriers and facilitators to deliberate practice using take-home laparoscopic simulators
This research was funded by The Association for the Study of Medical Education and the UK General Medical Council (Excellent Medical Education Joint Award). Open Access via Springer Compact AgreementPeer reviewedPublisher PD
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Characterization of subsurface media from locations up- and down-gradient of a uranium-contaminated aquifer.
The processing of sediment to accurately characterize the spatially-resolved depth profiles of geophysical and geochemical properties along with signatures of microbial density and activity remains a challenge especially in complex contaminated areas. This study processed cores from two sediment boreholes from background and contaminated core sediments and surrounding groundwater. Fresh core sediments were compared by depth to capture the changes in sediment structure, sediment minerals, biomass, and pore water geochemistry in terms of major and trace elements including pollutants, cations, anions, and organic acids. Soil porewater samples were matched to groundwater level, flow rate, and preferential flows and compared to homogenized groundwater-only samples from neighboring monitoring wells. Groundwater analysis of nearby wells only revealed high sulfate and nitrate concentrations while the same analysis using sediment pore water samples with depth was able to suggest areas high in sulfate- and nitrate-reducing bacteria based on their decreased concentration and production of reduced by-products that could not be seen in the groundwater samples. Positive correlations among porewater content, total organic carbon, trace metals and clay minerals revealed a more complicated relationship among contaminant, sediment texture, groundwater table, and biomass. The fluctuating capillary interface had high concentrations of Fe and Mn-oxides combined with trace elements including U, Th, Sr, Ba, Cu, and Co. This suggests the mobility of potentially hazardous elements, sediment structure, and biogeochemical factors are all linked together to impact microbial communities, emphasizing that solid interfaces play an important role in determining the abundance of bacteria in the sediments
Early outcomes in human lung transplantation with Thymoglobulin or Campath-1H for recipient pretreatment followed by posttransplant tacrolimus near-monotherapy
Objectives: Acute and chronic rejection remain unresolved problems after lung transplantation, despite heavy multidrug immunosuppression. In turn, the strong immunosuppression has been responsible for mortality and pervasive morbidity. It also has been postulated to interdict potential mechanisms of alloengraftment. Methods: In 48 lung recipients we applied 2 therapeutic principles: (1) recipient pretreatment with antilymphoid antibody preparations (Thymoglobulin [SangStat, Fremont, Calif] or Campath [alemtuzumab; manufactured by ILEX Pharmaceuticals, LP, San Antonio, Tex; distributed by Berlex Laboratories, Richmond, Calif]) and (2) minimal posttransplant immunosuppression with tacrolimus monotherapy or near-monotherapy. Our principal analysis was of the events during the critical first 6 posttransplant months of highest immunologic and infectious disease risk. Results were compared with those of 28 historical lung recipients treated with daclizumab induction and triple immunosuppression (tacrolimus-prednisone-azathioprine). Results: Recipient pretreatment with both antilymphoid preparations allowed the use of postoperative tacrolimus monotherapy with prevention or control of acute rejection. Freedom from rejection was significantly greater with Campath than with Thymoglobulin (P = .03) or daclizumab (P = .05). After lymphoid depletion with Thymoglobulin or Campath, patient and graft survival at 6 months was 90% or greater. Patient and graft survival after 9 to 24 months is 84.2% in the Thymoglobulin cohort, and after 10 to 12 months, it is 90% in the Campath cohort. There has been a subjective improvement in quality of life relative to our historical experience. Conclusion: Our results suggest that improvements in lung transplantation can be accomplished by altering the timing, dosage, and approach to immunosuppression in ways that might allow natural mechanisms of alloengraftment and diminish the magnitude of required maintenance immunosuppression. Copyright © 2005 by The American Association for Thoracic Surgery
Eruptive modes and hiatus of volcanism at West Mata seamount, NE Lau basin : 1996–2012
Author Posting. © American Geophysical Union, 2014. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 15 (2014): 4093–4115, doi:10.1002/2014GC005387.We present multiple lines of evidence for years to decade-long changes in the location and character of volcanic activity at West Mata seamount in the NE Lau basin over a 16 year period, and a hiatus in summit eruptions from early 2011 to at least September 2012. Boninite lava and pyroclasts were observed erupting from its summit in 2009, and hydroacoustic data from a succession of hydrophones moored nearby show near-continuous eruptive activity from January 2009 to early 2011. Successive differencing of seven multibeam bathymetric surveys of the volcano made in the 1996–2012 period reveals a pattern of extended constructional volcanism on the summit and northwest flank punctuated by eruptions along the volcano's WSW rift zone (WSWRZ). Away from the summit, the volumetrically largest eruption during the observational period occurred between May 2010 and November 2011 at ∼2920 m depth near the base of the WSWRZ. The (nearly) equally long ENE rift zone did not experience any volcanic activity during the 1996–2012 period. The cessation of summit volcanism recorded on the moored hydrophone was accompanied or followed by the formation of a small summit crater and a landslide on the eastern flank. Water column sensors, analysis of gas samples in the overlying hydrothermal plume and dives with a remotely operated vehicle in September 2012 confirmed that the summit eruption had ceased. Based on the historical eruption rates calculated using the bathymetric differencing technique, the volcano could be as young as several thousand years.Support for R.W.E. during this study was by internal NOAA funding to the NOAA Vents Program (now Earth-Ocean Interactions Program). The NSF Ridge 2000 and MARGINS programs played a major role in the planning and justification for the 2009 rapid response proposal that funded the May 2009 expedition. MBARI provided support and outstanding postprocessing of the multibeam bathymetry from the D. Allan B. AUV multibeam sonar used in this study. NSF also provided major funding for the 2009 expedition (OCE930025 and OCE-0934660 to JAR) and for the 210Po-210Pb radiometric dating (OCE-0929881 and for the 210Po-210Pb radiometric dating (OCE-0929881 to KHR)). The NOAA Office of Exploration and Research provided major funding for the 2009 and 2012 field programs.2015-04-3
Incorporating temporal and spatial variability of salt-marsh foraminifera into sea-level reconstructions
Foraminifera from salt-marsh environments have been used extensively in quantitative relative sea-level reconstructions due to their strong relationship with tidal level. However, the influence of temporal and spatial
variability of salt-marsh foraminifera on quantitative reconstructions remains unconstrained. Here, we conducted a monitoring study of foraminifera from four intertidal monitoring stations in New Jersey from high
marsh environments over three years that included several extreme weather (temperature, precipitation, and
storm surge) events. We sampled four replicates from each station seasonally (four times per year) for a total of
188 samples. The dead foraminiferal assemblages were separated into four site-specific assemblages. After accounting for systematic trends in changes in foraminifera over time among stations, the distribution of foraminiferal assemblages across monitoring stations explained ~87% of the remaining variation, while ~13% can
be explained by temporal and/or spatial variability among the replicate samples. We applied a Bayesian transfer
function to estimate the elevation of the four monitoring stations. All samples from each station predicted an
elevation estimate within a 95% uncertainty interval consistent with the observed elevation of that station.
Combining samples into replicate- and seasonal-aggregate datasets decreased elevation estimate uncertainty,
with the greatest decrease in aggregate datasets from Fall and Winter. Information about the temporal and
spatial variability of modern foraminiferal distributions was formally incorporated into the Bayesian transfer
function through informative foraminifera variability priors and was applied to a Common Era relative sea-level
record in New Jersey. The average difference in paleomarsh elevation estimates and uncertainties using an
informative vs uninformative prior was minimal (< 0.01 m and 0.01 m, respectively). The dead foraminiferal
assemblages remained consistent on temporal and small spatial scales, even during extreme weather events.
Therefore, even when accounting for variability of modern foraminifera, foraminiferal-based relative sea-level
reconstructions from high marsh environments remain robust and reproducible
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